LDB2

LDB2
Identifikatori
Aliasi	LDB2
Vanjski ID-jevi	OMIM: 603450 MGI: 894670 HomoloGene: 989 GeneCards: LDB2
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	16,898,678 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	44,957,022 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje enzima; • LIM domain binding; • GO:0001104 transcription coregulator activity; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• jedro; • transcription regulator complex; • cell leading edge; • Jedarce; • ćelijska membrana;
Biološki proces	• GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • hair follicle development; • positive regulation of cellular component biogenesis; • epithelial structure maintenance; • somatic stem cell population maintenance; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of kinase activity; • regulation of cell migration; • GO:1901227 negative regulation of transcription by RNA polymerase II; • multicellular organism development; • GO:0045996 negative regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	9079
	16826
	ENSG00000169744
	ENSMUSG00000039706
	O43679
	O55203
	NM_001130834; NM_001290; NM_001304434; NM_001304435
NM_001077398; NM_001286348; NM_010698; NM_001347349; NM_001359070;
	NM_001359071
	NP_001124306; NP_001281; NP_001291363; NP_001291364
NP_001070866; NP_001273277; NP_001334278; NP_034828; NP_001345999;
	NP_001346000
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 2 sa vezujućim domenom LIM jest protein koji je kod ljudi kodiran genom LDB2 sa hromosoma 4.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 373 aminokiseline, а molekulska težina 42.793 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSSTPHDPFY	SSPFGPFYRR	HTPYMVQPEY	RIYEMNKRLQ	SRTEDSDNLW
WDAFATEFFE	DDATLTLSFC	LEDGPKRYTI	GRTLIPRYFS	TVFEGGVTDL
YYILKHSKES	YHNSSITVDC	DQCTMVTQHG	KPMFTKVCTE	GRLILEFTFD
DLMRIKTWHF	TIRQYRELVP	RSILAMHAQD	PQVLDQLSKN	ITRMGLTNFT
LNYLRLCVIL	EPMQELMSRH	KTYNLSPRDC	LKTCLFQKWQ	RMVAPPAEPT
RQPTTKRRKR	KNSTSSTSNS	SAGNNANSTG	SKKKTTAANL	SLSSQVPDVM
VVGEPTLMGG	EFGDEDERLI	TRLENTQYDA	ANGMDDEEDF	NNSPALGNNS
PWNSKPPATQ	ETKSENPPPQ	ASQ

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169744 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039706 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Feb 1999). "Selection system for genes encoding nuclear-targeted proteins". Nat Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.
^ Retaux S, Rogard M, Bach I, Failli V, Besson MJ (Feb 1999). "Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain". J Neurosci. 19 (2): 783–93. doi:10.1523/JNEUROSCI.19-02-00783.1999. PMC 6782204. PMID 9880598.
^ Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem. 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853.
^ "Entrez Gene: LDB2 LIM domain binding 2".
^ "UniProt, O43679" (jezik: engleski). Pristupljeno 29. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Mamm. Genome. 9 (11): 921–4. doi:10.1007/s003359900899. PMID 9799849. S2CID 28813194.
Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2". J. Hum. Genet. 44 (2): 112–5. doi:10.1007/s100380050120. PMID 10083735.
Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. S2CID 22326394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169744 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039706 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9853615-5] Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Feb 1999). "Selection system for genes encoding nuclear-targeted proteins". Nat Biotechnol. 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615. S2CID 20001769.

[pmid9880598-6] Retaux S, Rogard M, Bach I, Failli V, Besson MJ (Feb 1999). "Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain". J Neurosci. 19 (2): 783–93. doi:10.1523/JNEUROSCI.19-02-00783.1999. PMC 6782204. PMID 9880598.

[pmid10861853-7] Kotaka M, Kostin S, Ngai S, Chan K, Lau Y, Lee SM, Li H, Ng EK, Schaper J, Tsui SK, Fung K, Lee C, Waye MM (Oct 2000). "Interaction of hCLIM1, an enigma family protein, with alpha-actinin 2". J Cell Biochem. 78 (4): 558–65. doi:10.1002/1097-4644(20000915)78:4<558::AID-JCB5>3.0.CO;2-I. PMID 10861853.

[entrez-8] "Entrez Gene: LDB2 LIM domain binding 2".

[UniProt-9] "UniProt, O43679" (jezik: engleski). Pristupljeno 29. 10. 2021.

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