LUC7L3

LUC7L3
Identifikatori
Aliasi	LUC7L3
Vanjski ID-jevi	OMIM: 609434 MGI: 1914934 HomoloGene: 75056 GeneCards: LUC7L3
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	50,756,219 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	94,212,814 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • mRNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• U1 snRNP; • U2-type prespliceosome; • jedro; • nukleoplazma; • nuclear speck;
Biološki proces	• mRNA processing; • mRNA splice site selection; • Prerada RNK;
	Izvori:Amigo / QuickGO
Ortolozi
	51747
	67684
	ENSG00000108848
	ENSMUSG00000020863
	O95232
	Q5SUF2
	NM_006107; NM_016424; NM_001330330
	NM_026313; NM_001361573; NM_001361574; NM_001361575
	NP_001317259; NP_006098; NP_057508
	NP_080589; NP_001348502; NP_001348503; NP_001348504
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

LUC7-oliki 3 pre-iRNK faktor prerade (LUC7L3), znan i kao preeksprimirani protein vezan sa rezistencijom na cisplatin ili CROP je ljudski gen.^[5]

Ovaj gen kodira preeksprimirani protein povezan sa rezistencijom na cisplatin (CROP). N-terminalna polovina CROP-a sadrži motive cistein/histidina i leucinska ponavljanja poput patentnih zatvarača, a C-terminalna polovina bogata je arginininskim i glutamatnim ostacima (RE domen) i argininskim i serinskim ostacima (RS domen). Ovaj protein lokalizira se tačkastim obrascem u jedru i mogao bi biti uključen u stvaranje splajsosom, putem RE i RS domena. Pronađene su dvije varijante transkripta kojE kodiraju isti protein ovog gena.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 432 aminokiseline, a molekulska težina 51.466 Da.^[6].

10	20	30	40	50
MISAAQLLDE	LMGRDRNLAP	DEKRSNVRWD	HESVCKYYLC	GFCPAELFTN
TRSDLGPCEK	IHDENLRKQY	EKSSRFMKVG	YERDFLRYLQ	SLLAEVERRI
RRGHARLALS	QNQQSSGAAG	PTGKNEEKIQ	VLTDKIDVLL	QQIEELGSEG
KVEEAQGMMK	LVEQLKEERE	LLRSTTSTIE	SFAAQEKQME	VCEVCGAFLI
VGDAQSRVDD	HLMGKQHMGY	AKIKATVEEL	KEKLRKRTEE	PDRDERLKKE
KQEREEREKE	REREREERER	KRRREEEERE	KERARDRERR	KRSRSRSRHS
SRTSDRRCSR	SRDHKRSRSR	ERRRSRSRDR	RRSRSHDRSE	RKHRSRSRDR
RRSKSRDRKS	YKHRSKSRDR	EQDRKSKEKE	KRGSDDKKSS	VKSGSREKQS
EDTNTESKES	DTKNEVNGTS	EDIKSEGDTQ	SN

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108848 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020863 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CROP cisplatin resistance-associated overexpressed protein".
^ "UniProt, O95232". Pristupljeno June 24, 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Nishii Y, Morishima M, Kakehi Y, et al. (2000). "CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line". FEBS Lett. 465 (2–3): 153–6. doi:10.1016/S0014-5793(99)01744-5. PMID 10631324. S2CID 7918526.
Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013. S2CID 25064683.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Umehara H, Nishii Y, Morishima M, et al. (2003). "Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A". Biochem. Biophys. Res. Commun. 301 (2): 324–9. doi:10.1016/S0006-291X(02)03017-6. PMID 12565863.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains". Eur. J. Immunol. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Puig O, Bragado-Nilsson E, Koski T, Séraphin B (2007). "The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human". Nucleic Acids Res. 35 (17): 5874–85. doi:10.1093/nar/gkm505. PMC 2034479. PMID 17726058.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma LUC7L3 i stranica sa detaljima o genu LUC7L3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108848 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020863 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CROP cisplatin resistance-associated overexpressed protein".

[UniProt-6] "UniProt, O95232". Pristupljeno June 24, 2021.

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