MLF1IP

MLF1IP
Identifikatori
Aliasi	CENPU
Vanjski ID-jevi	OMIM: 611511 MGI: 1919126 HomoloGene: 11629 GeneCards: CENPU
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	184,734,130 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	47,033,042 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• hromosom; • citoplazma; • citosol; • Primarno suženje; • jedro; • kinetohor; • nukleoplazma; • centar organizacije mikrotubula;
Biološki proces	• chordate embryonic development; • GO:0022415 viral process; • GO:0009373 regulation of transcription, DNA-templated; • GO:0061641 CENP-A containing chromatin assembly; • transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	79682
	71876
	ENSG00000151725
	ENSMUSG00000031629
	Q71F23
	Q8C4M7
	NM_024629
	NM_027973; NM_001368403
	NP_078905
	NP_082249; NP_001355332
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Centromerni protein U jest protein koji je kod ljudi kodiran genom CENPU sa hromosoma 4.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 418 aminokiselina, а molekulska težina 47.522 Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MAPRGRRRPR	PHRSEGARRS	KNTLERTHSM	KDKAGQKCKP	IDVFDFPDNS
DVSSIGRLGE	NEKDEETYET	FDPPLHSTAI	YADEEEFSKH	CGLSLSSTPP
GKEAKRSSDT	SGNEASEIES	VKISAKKPGR	KLRPISDDSE	SIEESDTRRK
VKSAEKISTQ	RHEVIRTTAS	SELSEKPAES	VTSKKTGPLS	AQPSVEKENL
AIESQSKTQK	KGKISHDKRK	KSRSKAIGSD	TSDIVHIWCP	EGMKTSDIKE
LNIVLPEFEK	THLEHQQRIE	SKVCKAAIAT	FYVNVKEQFI	KMLKESQMLT
NLKRKNAKMI	SDIEKKRQRM	IEVQDELLRL	EPQLKQLQTK	YDELKERKSS
LRNAAYFLSN	LKQLYQDYSD	VQAQEPNVKE	TYDSSSLPAL	LFKARTLLGA
ESHLRNINHQ	LEKLLDQG

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (maj 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (maj 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
^ "Entrez Gene: MLF1IP MLF1 interacting protein".
^ "UniProt, Q71F23" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zhang YJ, Pan HY, Gao SJ (2002). "Reverse transcription slippage over the mRNA secondary structure of the LIP1 gene". BioTechniques. 31 (6): 1286–1294. doi:10.2144/01316st02. PMID 11768657.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Pan HY, Zhang YJ, Wang XP, et al. (2003). "Identification of a Novel Cellular Transcriptional Repressor Interacting with the Latent Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus". J. Virol. 77 (18): 9758–68. doi:10.1128/JVI.77.18.9758-9768.2003. PMC 224565. PMID 12941884.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hanissian SH, Teng B, Akbar U, et al. (2005). "Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma". Brain Res. 1047 (1): 56–64. doi:10.1016/j.brainres.2005.04.017. PMID 15893739. S2CID 30594722.
Minoshima Y, Hori T, Okada M, et al. (2005). "The Constitutive Centromere Component CENP-50 Is Required for Recovery from Spindle Damage". Mol. Cell. Biol. 25 (23): 10315–28. doi:10.1128/MCB.25.23.10315-10328.2005. PMC 1291240. PMID 16287847.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Izuta H, Ikeno M, Suzuki N, et al. (2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
Kang YH, Park JE, Yu LR, et al. (2006). "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation". Mol. Cell. 24 (3): 409–22. doi:10.1016/j.molcel.2006.10.016. PMID 17081991.
Suzuki H, Arakawa Y, Ito M, et al. (2007). "MLF1-interacting protein is mainly localized in nucleolus through N-terminal bipartite nuclear localization signal". Anticancer Res. 27 (3B): 1423–30. PMID 17595757.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151725 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031629 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15116101-5] Hanissian SH, Akbar U, Teng B, Janjetovic Z, Hoffmann A, Hitzler JK, Iscove N, Hamre K, Du X, Tong Y, Mukatira S, Robertson JH, Morris SW (Apr 2004). "cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP". Oncogene. 23 (20): 3700–7. doi:10.1038/sj.onc.1207448. PMID 15116101.

[pmid16622420-6] Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (maj 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.

[pmid16622419-7] Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (maj 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.

[entrez-8] "Entrez Gene: MLF1IP MLF1 interacting protein".

[UniProt-9] "UniProt, Q71F23" (jezik: engleski). Pristupljeno 30. 10. 2021.

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