NABP1

NABP1
Identifikatori
Aliasi	NABP1
Vanjski ID-jevi	OMIM: 612103 MGI: 1923258 HomoloGene: 57094 GeneCards: NABP1
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	191,741,097 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	51,517,584 bp
Ontologija gena
Molekularna funkcija	• single-stranded DNA binding; • vezivanje sa DNK; • GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK;
Ćelijska komponenta	• jedro; • nukleoplazma; • citosol; • SOSS complex;
Biološki proces	• response to ionizing radiation; • double-strand break repair via homologous recombination; • GO:0100026 Popravka DNK; • cellular response to DNA damage stimulus; • snRNA transcription by RNA polymerase II; • mitotic cell cycle checkpoint signaling;
	Izvori:Amigo / QuickGO
Ortolozi
	64859
	109019
	ENSG00000173559
	ENSMUSG00000026107
	Q96AH0
	Q8BGW5
	NM_001031716; NM_001254736; NM_022837
	NM_028696; NM_001310548; NM_001310549
	NP_001026886; NP_001241665
	NP_001297477; NP_001297478; NP_082972
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Nukleinskokiselinski-vezujući protein 1 jest protein koji je kod ljudi kodiran genom NABP1 sa hromosoma 2.^[5]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 204 aminokiseline, a molekulska težina 22.423 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MNRVNDPLIF	IRDIKPGLKN	LNVVFIVLEI	GRVTKTKDGH	EVRSCKVADK
TGSITISVWD	EIGGLIQPGD	IIRLTRGYAS	MWKGCLTLYT	GRGGELQKIG
EFCMVYSEVP	NFSEPNPDYR	GQQNKGAQSE	QKNNSMNSNM	GTGTFGPVGN
GVHTGPESRE	HQFSHAGRSN	GRGLINPQLQ	GTASNQTVMT	TISNGRDPRR
AFKR

Funkcija[uredi | uredi izvor]

Vezujući proteini za jednolančanu DNK (ssDNK), kao što je OBFC2A, su sveprisutni i neophodni za različite metaboličke procese DNK, uključujući replikaciju, rekombinaciju i otkrivanje i popravak oštećenja.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173559 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026107 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nucleic acid binding protein 1".
^ "UniProt, Q96AH0" (jezik: engleski). Pristupljeno 18. 11. 2021.
^ Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (maj 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

Dopunska literatura[uredi | uredi izvor]

Li Y, Bolderson E, Kumar R, Muniandy PA, Xue Y, Richard DJ, Seidman M, Pandita TK, Khanna KK, Wang W (august 2009). "HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response". The Journal of Biological Chemistry. 284 (35): 23525–31. doi:10.1074/jbc.C109.039586. PMC 2749126. PMID 19605351.
Huang J, Gong Z, Ghosal G, Chen J (august 2009). "SOSS complexes participate in the maintenance of genomic stability". Molecular Cell. 35 (3): 384–93. doi:10.1016/j.molcel.2009.06.011. PMC 2756616. PMID 19683501.
Malovannaya A, Li Y, Bulynko Y, Jung SY, Wang Y, Lanz RB, O'Malley BW, Qin J (februar 2010). "Streamlined analysis schema for high-throughput identification of endogenous protein complexes". Proceedings of the National Academy of Sciences of the United States of America. 107 (6): 2431–6. Bibcode:2010PNAS..107.2431M. doi:10.1073/pnas.0912599106. PMC 2823922. PMID 20133760.

Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država, koji je u javnom vlasništvu.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173559 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026107 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nucleic acid binding protein 1".

[UniProt-6] "UniProt, Q96AH0" (jezik: engleski). Pristupljeno 18. 11. 2021.

[7] Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK (maj 2008). "Single-stranded DNA-binding protein hSSB1 is critical for genomic stability". Nature. 453 (7195): 677–81. Bibcode:2008Natur.453..677R. doi:10.1038/nature06883. PMID 18449195. S2CID 4322436.

[1]

[2]

[3]

[4]

[5]

[6]

[7]