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Neuropeptid B je kratki, biološki aktivan peptid čiji je prekursor u ljudi kodiran genom NBP . Neuropeptid B djeluje putem dva G-vezana receptora, neuropeptidni B/W receptori , zvani NPBW1 i NPBW2 kodirani genima NPBWR1 i NPBWR2 . Smatra se da je neuropeptid B povezan s regulacijom hranjenja, neuroendokrinim sistemom , pamćenjem , učenjem i aferentnim putem bola .[5] [6] CNS -u, sa visokim nivoima u substantia nigra hipotalamusu , hipokampusu i kičmenoj moždini .
Dužina polipeptidnog lanca je 125 aminokiselina , sa molekulskom težinom od 13.097.[7]
Aminokiselinska sekvenca
Simboli
10 20 30 40 50 MARSATLAAA ALALCLLLAP PGLAWYKPAA GHSSYSVGRA AGLLSGLRRS PYARRSQPYR GAEPPGGAGA SPELQLHPRL RSLAVCVQDV APNLQRCERL PDGRGTYQCK ANVFLSLRAA DCLAA
^ a b c GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl , maj 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl , maj 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system" . British Journal of Pharmacology . 148 (8): 1033–41. doi :10.1038/sj.bjp.0706825 . PMC 1752024 PMID 16847439 . ^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion". Results and Problems in Cell Differentiation . 46 : 239–56. doi :10.1007/400_2007_056 . ISBN 978-3-540-78350-3 PMID 18204824 . ^ "UniProt, Q8NG41" . Pristupljeno 12. 9. 2017 .
