PREX2
Rac faktor 2 razmjene ovisan o fosfatidilinositol-3,4,5-trisfosfatu je protein koji je kod ljudi kodiran genom PREX2.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.606 aminokiselina, а molekulska težina 182.622 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MSEDSRGDSR | AESAKDLEKQ | LRLRVCVLSE | LQKTERDYVG | TLEFLVSAFL | ||||
HRMNQCAASK | VDKNVTEETV | KMLFSNIEDI | LAVHKEFLKV | VEECLHPEPN | ||||
AQQEVGTCFL | HFKDKFRIYD | EYCSNHEKAQ | KLLLELNKIR | TIRTFLLNCM | ||||
LLGGRKNTDV | PLEGYLVTPI | QRICKYPLIL | KELLKRTPRK | HSDYAAVMEA | ||||
LQAMKAVCSN | INEAKRQMEK | LEVLEEWQSH | IEGWEGSNIT | DTCTEMLMCG | ||||
VLLKISSGNI | QERVFFLFDN | LLVYCKRKHR | RLKNSKASTD | GHRYLFRGRI | ||||
NTEVMEVENV | DDGTADFHSS | GHIVVNGWKI | HNTAKNKWFV | CMAKTPEEKH | ||||
EWFEAILKER | ERRKGLKLGM | EQDTWVMISE | QGEKLYKMMC | RQGNLIKDRK | ||||
RKLTTFPKCF | LGSEFVSWLL | EIGEIHRPEE | GVHLGQALLE | NGIIHHVTDK | ||||
HQFKPEQMLY | RFRYDDGTFY | PRNEMQDVIS | KGVRLYCRLH | SLFTPVIRDK | ||||
DYHLRTYKSV | VMANKLIDWL | IAQGDCRTRE | EAMIFGVGLC | DNGFMHHVLE | ||||
KSEFKDEPLL | FRFFSDEEME | GSNMKHRLMK | HDLKVVENVI | AKSLLIKSNE | ||||
GSYGFGLEDK | NKVPIIKLVE | KGSNAEMAGM | EVGKKIFAIN | GDLVFMRPFN | ||||
EVDCFLKSCL | NSRKPLRVLV | STKPRETVKI | PDSADGLGFQ | IRGFGPSVVH | ||||
AVGRGTVAAA | AGLHPGQCII | KVNGINVSKE | THASVIAHVT | ACRKYRRPTK | ||||
QDSIQWVYNS | IESAQEDLQK | SHSKPPGDEA | GDAFDCKVEE | VIDKFNTMAI | ||||
IDGKKEHVSL | TVDNVHLEYG | VVYEYDSTAG | IKCNVVEKMI | EPKGFFSLTA | ||||
KILEALAKSD | EHFVQNCTSL | NSLNEVIPTD | LQSKFSALCS | ERIEHLCQRI | ||||
SSYKKFSRVL | KNRAWPTFKQ | AKSKISPLHS | SDFCPTNCHV | NVMEVSYPKT | ||||
STSLGSAFGV | QLDSRKHNSH | DKENKSSEQG | KLSPMVYIQH | TITTMAAPSG | ||||
LSLGQQDGHG | LRYLLKEEDL | ETQDIYQKLL | GKLQTALKEV | EMCVCQIDDL | ||||
LSSITYSPKL | ERKTSEGIIP | TDSDNEKGER | NSKRVCFNVA | GDEQEDSGHD | ||||
TISNRDSYSD | CNSNRNSIAS | FTSICSSQCS | SYFHSDEMDS | GDELPLSVRI | ||||
SHDKQDKIHS | CLEHLFSQVD | SITNLLKGQA | VVRAFDQTKY | LTPGRGLQEF | ||||
QQEMEPKLSC | PKRLRLHIKQ | DPWNLPSSVR | TLAQNIRKFV | EEVKCRLLLA | ||||
LLEYSDSETQ | LRRDMVFCQT | LVATVCAFSE | QLMAALNQMF | DNSKENEMET | ||||
WEASRRWLDQ | IANAGVLFHF | QSLLSPNLTD | EQAMLEDTLV | ALFDLEKVSF | ||||
YFKPSEEEPL | VANVPLTYQA | EGSRQALKVY | FYIDSYHFEQ | LPQRLKNGGG | ||||
FKIHPVLFAQ | ALESMEGYYY | RDNVSVEEFQ | AQINAASLEK | VKQYNQKLRA | ||||
FYLDKSNSPP | NSTSKAAYVD | KLMRPLNALD | ELYRLVASFI | RSKRTAACAN | ||||
TACSASGVGL | LSVSSELCNR | LGACHIIMCS | SGVHRCTLSV | TLEQAIILAR | ||||
SHGLPPRYIM | QATDVMRKQG | ARVQNTAKNL | GVRDRTPQSA | PRLYKLCEPP | ||||
PPAGEE |
Klinički značaj[uredi | uredi izvor]
Mutacije u ovom genu često su se viđale u melanomima.[8]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000046889 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048960 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2". Pristupljeno 11. 5. 2012.
- ^ Rosenfeldt H, Vázquez-Prado J, Gutkind JS (august 2004). "P-REX2, a novel PI-3-kinase sensitive Rac exchange factor". FEBS Lett. 572 (1–3): 167–71. doi:10.1016/j.febslet.2004.06.097. PMID 15304342. S2CID 35668920.
- ^ "UniProt, Q70Z35" (jezik: engleski). Pristupljeno 21. 9. 2021.
- ^ Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA (maj 2012). "Melanoma genome sequencing reveals frequent PREX2 mutations" (PDF). Nature. 485 (7399): 502–6. doi:10.1038/nature11071. PMC 3367798. PMID 22622578.
Dopunska literatura[uredi | uredi izvor]
- Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC (august 2004). "P-Rex2, a new guanine-nucleotide exchange factor for Rac". FEBS Lett. 572 (1–3): 172–6. doi:10.1016/j.febslet.2004.06.096. PMID 15304343. S2CID 31436247.
- Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, Hernández-García R, Calderón-Salinas JV, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J (august 2007). "P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration". J. Biol. Chem. 282 (32): 23708–15. doi:10.1074/jbc.M703771200. PMID 17565979.
- Joseph RE, Norris FA (juli 2005). "Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2". J. Biol. Chem. 280 (30): 27508–12. doi:10.1074/jbc.M412495200. PMID 15897194.
- Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R (septembar 2009). "Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a". Science. 325 (5945): 1261–5. doi:10.1126/science.1173569. PMC 2936784. PMID 19729658.
- Leslie NR (2009). "P-REX2a driving tumorigenesis by PTEN inhibition". Sci Signal. 2 (94): pe68. doi:10.1126/scisignal.294pe68. PMID 19861688. S2CID 19953626.