PTPN14
Tirozin-protein fosfataza nereceptorski tip 14 jest enzim koji je kod ljudi kodiran genom PTPN14 sa hromosoma 1.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 1.187 aminokiselina, a molekulska težina 135.261 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MPFGLKLRRT | RRYNVLSKNC | FVTRIRLLDS | NVIECTLSVE | STGQECLEAV | ||||
| AQRLELRETH | YFGLWFLSKS | QQARWVELEK | PLKKHLDKFA | NEPLLFFGVM | ||||
| FYVPNVSWLQ | QEATRYQYYL | QVKKDVLEGR | LRCTLDQVIR | LAGLAVQADF | ||||
| GDYNQFDSQD | FLREYVLFPM | DLALEEAVLE | ELTQKVAQEH | KAHSGILPAE | ||||
| AELMYINEVE | RLDGFGQEIF | PVKDNHGNCV | HLGIFFMGIF | VRNRIGRQAV | ||||
| IYRWNDMGNI | THNKSTILVE | LINKEETALF | HTDDIENAKY | ISRLFATRHK | ||||
| FYKQNKICTE | QSNSPPPIRR | QPTWSRSSLP | RQQPYILPPV | HVQCGEHYSE | ||||
| THTSQDSIFH | GNEEALYCNS | HNSLDLNYLN | GTVTNGSVCS | VHSVNSLNCS | ||||
| QSFIQASPVS | SNLSIPGSDI | MRADYIPSHR | HSAIIVPSYR | PTPDYETVMR | ||||
| QMKRGILHTD | SQSQSLRNLN | IINTHAYNQP | EDLVYSQPEM | RERHPYTVPY | ||||
| GPQGVYSNKL | VSPSDQRNPK | NNVVPSKPGA | SAISHTVSTP | ELANMQLQGS | ||||
| HNYSTAHMLK | NYLFRPPPPY | PRPRPATSTP | DLASHRHKYV | SGSSPDLVTR | ||||
| KVQLSVKTFQ | EDSSPVVHQS | LQEVSEPLTA | TKHHGTVNKR | HSLEVMNSMV | ||||
| RGMEAMTLKS | LHLPMARRNT | LREQGPPEEG | SGSHEVPQLP | QYHHKKTFSD | ||||
| ATMLIHSSES | EEEEEEAPES | VPQIPMLREK | MEYSAQLQAA | LARIPNKPPP | ||||
| EYPGPRKSVS | NGALRQDQAS | LPPAMARARV | LRHGPAKAIS | MSRTDPPAVN | ||||
| GASLGPSISE | PDLTSVKERV | KKEPVKERPV | SEMFSLEDSI | IEREMMIRNL | ||||
| EKQKMAGLEA | QKRPLMLAAL | NGLSVARVSG | REENRVDATR | VPMDERFRTL | ||||
| KKKLEEGMVF | TEYEQIPKKK | ANGIFSTAAL | PENAERSRIR | EVVPYEENRV | ||||
| ELIPTKENNT | GYINASHIKV | VVGGAEWHYI | ATQGPLPHTC | HDFWQMVWEQ | ||||
| GVNVIAMVTA | EEEGGRTKSH | RYWPKLGSKH | SSATYGKFKV | TTKFRTDSVC | ||||
| YATTGLKVKH | LLSGQERTVW | HLQYTDWPDH | GCPEDVQGFL | SYLEEIQSVR | ||||
| RHTNSMLEGT | KNRHPPIVVH | CSAGVGRTGV | LILSELMIYC | LEHNEKVEVP | ||||
| MMLRLLREQR | MFMIQTIAQY | KFVYQVLIQF | LQNSRLI |
Funkcija[uredi | uredi izvor]
Protein kodiran ovim genom član je porodice PTP i PTPN14 Arhivirano 17. 12. 2021. na Wayback Machine potporodice tirozin protein-fosfataza. Poznato je da su PTP-ovi signalne molekule koje regulišu različite ćelijske procese, uključujući rast ćelije, diferencijaciju, mitotski ciklus i onkogenu transformaciju. Ovaj PTP sadrži N-terminalni nekatalitski domen sličnan onom kod proteina koji su povezani sa natporodicom citoskeletnih traka 4.1, što ukazuje na lokalizaciju ovog proteina na membrani ili citoskeletu. Specifična funkcija ovog PTP-a još nije utvrđena.[6]
Interakcije[uredi | uredi izvor]
Pokazalo se da PTPN14 reaguje sa beta-kateninom.[8]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000152104 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026604 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.
- ^ a b "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
- ^ "UniProt, Q15678" (jezik: engleski). Pristupljeno 16. 12. 2021.
- ^ Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
Dopunska literatura[uredi | uredi izvor]
- Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (Jun 1994). "The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953. S2CID 24662426.
- Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T (Apr 1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". The Journal of Biological Chemistry. 274 (18): 12905–9. doi:10.1074/jbc.274.18.12905. PMID 10212280.
- Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T (Jul 1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". The Journal of Biological Chemistry. 274 (29): 20717–24. doi:10.1074/jbc.274.29.20717. PMID 10400706.
- Aoyama K, Matsuda T, Aoki N (Dec 1999). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochemical and Biophysical Research Communications. 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID 10600535.
- Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Sep 2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". Journal of Cell Science. 113 ( Pt 17) (17): 3117–23. doi:10.1242/jcs.113.17.3117. hdl:2440/9579. PMID 10934049.
- Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
- Barr AJ, Debreczeni JE, Eswaran J, Knapp S (Jun 2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins. 63 (4): 1132–6. doi:10.1002/prot.20958. PMID 16534812. S2CID 7186900.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Vanjski linkovi[uredi | uredi izvor]
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 14 (PTPN14)