RAB3IP

RAB3IP
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4LHX, 4LHY, 4LHZ, 4UJ3, 4UJ4, 4UJ5
Identifikatori
Aliasi	RAB3IP
Vanjski ID-jevi	OMIM: 608686 MGI: 105933 HomoloGene: 32340 GeneCards: RAB3IP
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	69,823,204 bp
Lokacija gena (miš)
Hrom.	Hromosom 10 (miš)
Kraj	116,786,674 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • guanyl-nucleotide exchange factor activity; • vezivanje identičnih proteina;
Ćelijska komponenta	• citoplazma; • ciliary basal body; • citosol; • centrosom; • projekcija ćelije; • citoskelet; • lamellipodium; • jedro;
Biološki proces	• protein localization to organelle; • protein transport; • Golgi to plasma membrane transport; • protein targeting to membrane; • cilium assembly; • ciliary basal body-plasma membrane docking;
	Izvori:Amigo / QuickGO
Ortolozi
	117177
	216363
	ENSG00000127328
	ENSMUSG00000064181
	Q96QF0
	Q68EF0
NM_001024647; NM_001278402; NM_022456; NM_175623; NM_175624;
	NM_175625; NM_175626; NM_175627
	NM_001003950; NM_001359645
NP_001019818; NP_001265331; NP_071901; NP_783322; NP_783323;
	NP_783324
	NP_001003950; NP_001346574
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

RAB3A-interaktivni protein je protein koji je kod ljudi kodiran genom RAB3IP.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 476 aminokiselina, a molekulska težina 53.021Da.^[6]

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MGLKKMKGLS	YDEAFAMAND	PLEGFHEVNL	ASPTSPDLLG	VYESGTQEQT
TSPSVIYRPH	PSALSSVPIQ	ANALDVSELP	TQPVYSSPRR	LNCAEISSIS
FHVTDPAPCS	TSGVTAGLTK	LTTRKDNYNA	EREFLQGATI	TEACDGSDDI
FGLSTDSLSR	LRSPSVLEVR	EKGYERLKEE	LAKAQRELKL	KDEECERLSK
VRDQLGQELE	ELTASLFEEA	HKMVREANIK	QATAEKQLKE	AQGKIDVLQA
EVAALKTLVL	SSSPTSPTQE	PLPGGKTPFK	KGHTRNKSTS	SAMSGSHQDL
SVIQPIVKDC	KEADLSLYNE	FRLWKDEPTM	DRTCPFLDKI	YQEDIFPCLT
FSKSELASAV	LEAVENNTLS	IEPVGLQPIR	FVKASAVECG	GPKKCALTGQ
SKSCKHRIKL	GDSSNYYYIS	PFCRYRITSV	CNFFTYIRYI	QQGLVKQQDV
DQMFWEVMQL	RKEMSLAKLG	YFKEEL

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127328 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000064181 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAB3IP RAB3A interacting protein (rabin3)".
^ "UniProt, Q96QF0". Pristupljeno 14. 8. 2021.

Dopunska literatura[uredi | uredi izvor]

Newport J, Roemer MI (1975). "Comparative perinatal mortality under medical care foundations and other delivery models". Inquiry : A Journal of Medical Care Organization, Provision and Financing. 12 (1): 10–7. PMID 123217.
Brondyk WH, McKiernan CJ, Fortner KA, et al. (1995). "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A". Mol. Cell. Biol. 15 (3): 1137–43. doi:10.1128/MCB.15.3.1137. PMC 230335. PMID 7532276.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
de Bruijn DR, dos Santos NR, Kater-Baats E, et al. (2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes Chromosomes Cancer. 34 (3): 285–98. doi:10.1002/gcc.10073. PMID 12007189. S2CID 11734893.
Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP Exchange Factor Is Involved in Actin Remodeling and Polarized Membrane Transport". Mol. Biol. Cell. 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC 124888. PMID 12221131.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

Vanjski linkovi[uredi | uredi izvor]

Q96QF0

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127328 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000064181 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RAB3IP RAB3A interacting protein (rabin3)".

[UniProt-6] "UniProt, Q96QF0". Pristupljeno 14. 8. 2021.

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