SEC24B

SEC24B
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	3EH1
Identifikatori
Aliasi	SEC24B
Vanjski ID-jevi	OMIM: 607184 MGI: 2139764 HomoloGene: 55968 GeneCards: SEC24B
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	109,540,896 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	129,855,202 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona cinka; • vezivanje iona metala;
Ćelijska komponenta	• citoplazma; • endoplasmic reticulum membrane; • Golđijeva membrana; • Endoplazmatski retikulum; • membrana; • COPII vesicle coat; • citosol; • ER to Golgi transport vesicle membrane; • GO:0016023 citoplazmatska vezikula; • COPII-coated ER to Golgi transport vesicle;
Biološki proces	• lung morphogenesis; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • pulmonary artery morphogenesis; • antigen processing and presentation of peptide antigen via MHC class I; • regulation of establishment of planar polarity involved in neural tube closure; • coronary artery morphogenesis; • outflow tract morphogenesis; • auditory receptor cell morphogenesis; • aorta morphogenesis; • auditory receptor cell stereocilium organization; • neural tube closure; • COPII vesicle coating; • protein transport; • intracellular protein transport; • regulation of cargo loading into COPII-coated vesicle; • lung lobe morphogenesis; • cochlear nucleus development; • endoplasmic reticulum to Golgi vesicle-mediated transport; • vesicle-mediated transport; • COPII-coated vesicle cargo loading;
	Izvori:Amigo / QuickGO
Ortolozi
	10427
	99683
	ENSG00000138802
	ENSMUSG00000001052
	O95487
	n/a
	NM_001042734; NM_001300813; NM_006323; NM_001318085; NM_001318086
	NM_207209
	NP_001036199; NP_001287742; NP_001305014; NP_001305015; NP_006314
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski transportni protein Sec24B jest protein koji je kod ljudi kodiran genom SEC24B sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.268 aminokiselina, а molekulska težina 137.418 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSAPAGSSHP	AASARIPPKF	GGAAVSGAAA	PAGPGAGPAP	HQQNGPAQNQ
MQVPSGYGLH	HQNYIAPSGH	YSQGPGKMTS	LPLDTQCGDY	YSALYTVPTQ
NVTPNTVNQQ	PGAQQLYSRG	PPAPHIVGST	LGSFQGAASS	ASHLHTSASQ
PYSSFVNHYN	SPAMYSASSS	VASQGFPSTC	GHYAMSTVSN	AAYPSVSYPS
LPAGDTYGQM	FTSQNAPTVR	PVKDNSFSGQ	NTAISHPSPL	PPLPSQQHHQ
QQSLSGYSTL	TWSSPGLPST	QDNLIRNHTG	SLAVANNNPT	ITVADSLSCP
VMQNVQPPKS	SPVVSTVLSG	SSGSSSTRTP	PTANHPVEPV	TSVTQPSELL
QQKGVQYGEY	VNNQASSAPT	PLSSTSDDEE	EEEEDEEAGV	DSSSTTSSAS
PMPNSYDALE	GGSYPDMLSS	SASSPAPDPA	PEPDPASAPA	PASAPAPVVP
QPSKMAKPFG	YGYPTLQPGY	QNATAPLISG	VQPSNPVYSG	FQQYPQQYPG
VNQLSSSIGG	LSLQSSPQPE	SLRPVNLTQE	RNILPMTPVW	APVPNLNADL
KKLNCSPDSF	RCTLTNIPQT	QALLNKAKLP	LGLLLHPFRD	LTQLPVITSN
TIVRCRSCRT	YINPFVSFID	QRRWKCNLCY	RVNDVPEEFM	YNPLTRSYGE
PHKRPEVQNS	TVEFIASSDY	MLRPPQPAVY	LFVLDVSHNA	VEAGYLTILC
QSLLENLDKL	PGDSRTRIGF	MTFDSTIHFY	NLQEGLSQPQ	MLIVSDIDDV
FLPTPDSLLV	NLYESKELIK	DLLNALPNMF	TNTRETHSAL	GPALQAAFKL
MSPTGGRVSV	FQTQLPSLGA	GLLQSREDPN	QRSSTKVVQH	LGPATDFYKK
LALDCSGQQT	AVDLFLLSSQ	YSDLASLACM	SKYSAGCIYY	YPSFHYTHNP
SQAEKLQKDL	KRYLTRKIGF	EAVMRIRCTK	GLSMHTFHGN	FFVRSTDLLS
LANINPDAGF	AVQLSIEESL	TDTSLVCFQT	ALLYTSSKGE	RRIRVHTLCL
PVVSSLADVY	AGVDVQAAIC	LLANMAVDRS	VSSSLSDARD	ALVNAVVDSL
SAYGSTVSNL	QHSALMAPSS	LKLFPLYVLA	LLKQKAFRTG	TSTRLDDRVY
AMCQIKSQPL	VHLMKMIHPN	LYRIDRLTDE	GAVHVNDRIV	PQPPLQKLSA
EKLTREGAFL	MDCGSVFYIW	VGKGCDNNFI	EDVLGYTNFA	SIPQKMTHLP
ELDTLSSERA	RSFITWLRDS	RPLSPILHIV	KDESPAKAEF	FQHLIEDRTE
AAFSYYEFLL	HVQQQICK

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je član potporodice SEC24 porodice SEC23/SEC24, koja je uključena u promet vezikula. Kodirani protein je sličan komponenti Sec24p kvasca u COPII. COPII je kompleks proteina omotača, odgovoran za pupanje vezikula iz ER. Uloga ovog genskog proizvoda je implicirana u oblikovanju vezikula, kao i u selekciji i koncentraciji tereta. Za ovaj gen su pronađene dvije varijante transkripta koje kodiraju različite izoforme.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138802 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001052 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
^ ^a ^b "Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae)".
^ "UniProt, O95487" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Mol. Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138802 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001052 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10075675-5] Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.

[pmid10329445-6] Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.

[entrez-7] "Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae)".

[UniProt-8] "UniProt, O95487" (jezik: engleski). Pristupljeno 30. 10. 2021.

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