SEC24D

SEC24D
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	3EFO, 3EG9
Identifikatori
Aliasi	SEC24D
Vanjski ID-jevi	OMIM: 607186 MGI: 1916858 HomoloGene: 40986 GeneCards: SEC24D
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	118,838,683 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	123,159,290 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • SNARE binding; • vezivanje iona cinka; • vezivanje iona metala;
Ćelijska komponenta	• citoplazma; • endoplasmic reticulum membrane; • membrana; • Golđijeva membrana; • Endoplazmatski retikulum; • COPII vesicle coat; • citosol; • ER to Golgi transport vesicle membrane; • GO:0016023 citoplazmatska vezikula;
Biološki proces	• antigen processing and presentation of exogenous peptide antigen via MHC class II; • antigen processing and presentation of peptide antigen via MHC class I; • in utero embryonic development; • COPII vesicle coating; • protein transport; • intracellular protein transport; • vesicle-mediated transport; • endoplasmic reticulum to Golgi vesicle-mediated transport; • COPII-coated vesicle cargo loading;
	Izvori:Amigo / QuickGO
Ortolozi
	9871
	69608
	ENSG00000150961
	ENSMUSG00000039234
	O94855
	n/a
	NM_014822; NM_001318066
	NM_027135
	NP_001304995; NP_055637
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Proteinski transportni protein Sec24D jest protein koji je kod ljudi kodiran genom SEC24D sa hromosoma 4.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.032 aminokiseline, а molekulska težina 113.010 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSQQGYVATP	PYSQPQPGIG	LSPPHYGHYG	DPSHTASPTG	MMKPAGPLGA
TATRGMLPPG	PPPPGPHQFG	QNGAHATGHP	PQRFPGPPPV	NNVASSHAPY
QPSAQSSYPG	PISTSSVTQL	GSQLSAMQIN	SYGSGMAPPS	QGPPGPLSAT
SLQTPPRPPQ	PSILQPGSQV	LPPPPTTLNG	PGASPLPLPM	YRPDGLSGPP
PPNAQYQPPP	LPGQTLGAGY	PPQQANSGPQ	MAGAQLSYPG	GFPGGPAQMA
GPPQPQKKLD	PDSIPSPIQV	IENDRASRGG	QVYATNTRGQ	IPPLVTTDCM
IQDQGNASPR	FIRCTTYCFP	CTSDMAKQAQ	IPLAAVIKPF	ATIPSNESPL
YLVNHGESGP	VRCNRCKAYM	CPFMQFIEGG	RRYQCGFCNC	VNDVPPFYFQ
HLDHIGRRLD	HYEKPELSLG	SYEYVATLDY	CRKSKPPNPP	AFIFMIDVSY
SNIKNGLVKL	ICEELKTMLE	KIPKEEQEET	SAIRVGFITY	NKVLHFFNVK
SNLAQPQMMV	VTDVGEVFVP	LLDGFLVNYQ	ESQSVIHNLL	DQIPDMFADS
NENETVFAPV	IQAGMEALKA	ADCPGKLFIF	HSSLPTAEAP	GKLKNRDDKK
LVNTDKEKIL	FQPQTNVYDS	LAKDCVAHGC	SVTLFLFPSQ	YVDVASLGLV
PQLTGGTLYK	YNNFQMHLDR	QQFLNDLRND	IEKKIGFDAI	MRVRTSTGFR
ATDFFGGILM	NNTTDVEMAA	IDCDKAVTVE	FKHDDKLSED	SGALIQCAVL
YTTISGQRRL	RIHNLGLNCS	SQLADLYKSC	ETDALINFFA	KSAFKAVLHQ
PLKVIREILV	NQTAHMLACY	RKNCASPSAA	SQLILPDSMK	VLPVYMNCLL
KNCVLLSRPE	ISTDERAYQR	QLVMTMGVAD	SQLFFYPQLL	PIHTLDVKST
MLPAAVRCSE	SRLSEEGIFL	LANGLHMFLW	LGVSSPPELI	QGIFNVPSFA
HINTDMTLLP	EVGNPYSQQL	RMIMGIIQQK	RPYSMKLTIV	KQREQPEMVF
RQFLVEDKGL	YGGSSYVDFL	CCVHKEICQL	LN

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom je član potporodice SEC24 porodice SEC23/SEC24, koja je uključena u promet vezikula. Kodirani protein je sličan kvaščevoj Sec24p komponenti COPII. COPII je proteinski kompleks omotača, odgovoran za pupanje vezikula iz ER. Uloga ovog genskog proizvoda je implicirana u oblikovanju vezikula, kao i u selekciji i koncentraciji tereta.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150961 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039234 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
^ ^a ^b "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)".
^ "UniProt, O94855" (jezik: engleski). Pristupljeno 30. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150961 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039234 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[pmid10075675-6] Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.

[entrez-7] "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)".

[UniProt-8] "UniProt, O94855" (jezik: engleski). Pristupljeno 30. 10. 2021.

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