SFXN1

SFXN1
Identifikatori
Aliasi	SFXN1
Vanjski ID-jevi	OMIM: 615569 MGI: 2137677 HomoloGene: 41494 GeneCards: SFXN1
Lokacija gena (čovjek) Hrom. Hromosom 5 (čovjek) Bend 5q35.2 Početak 175,477,062 bp Kraj 175,529,742 bp
Lokacija gena (miš) Hrom. Hromosom 13 (miš) Bend 13 B1|13 28.4 cM Početak 54,225,888 bp Kraj 54,262,361 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • ion transmembrane transporter activity • L-serine transmembrane transporter activity • D-serine transmembrane transporter activity Ćelijska komponenta • integral component of membrane • membrana • mitohondrija • mitochondrial membranes • integral component of mitochondrial inner membrane • mitochondrial inner membrane Biološki proces • erythrocyte differentiation • ion transmembrane transport • iron ion homeostasis • iron ion transport • ion transport • transmembrane transport • one-carbon metabolic process • L-serine transport • D-serine transport • serine import into mitochondrion • amino acid transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	94081	14057
Ensembl	ENSG00000164466	ENSMUSG00000021474
UniProt	Q9H9B4	Q99JR1
RefSeq (mRNK)	NM_022754 NM_001322977 NM_001322978 NM_001322980 NM_001322981 NM_001322982 NM_001322983	NM_027324
RefSeq (bjelančevina)	NP_001309906 NP_001309907 NP_001309909 NP_001309910 NP_001309911 NP_001309912 NP_073591	NP_081600
Lokacija (UCSC)	Chr 5: 175.48 – 175.53 Mb	Chr 13: 54.23 – 54.26 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Siderofleksin-1 jest protein koji je kod ljudi kodiran genom SFXN1 sa hromosoma 5. Prema Nora Kory et al., genski proizvod SFXN1-a ima mitohondrijsku aktivnost serinskog transportera.

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 322 aminokiseline, а molekulska težina 35.619 Da.

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSGELPPNIN		IKEPRWDQST		FIGRANHFFT		VTDPRNILLT		NEQLESARKI
VHDYRQGIVP		PGLTENELWR		AKYIYDSAFH		PDTGEKMILI		GRMSAQVPMN
MTITGCMMTF		YRTTPAVLFW		QWINQSFNAV		VNYTNRSGDA		PLTVNELGTA
YVSATTGAVA		TALGLNALTK		HVSPLIGRFV		PFAAVAAANC		INIPLMRQRE
LKVGIPVTDE		NGNRLGESAN		AAKQAITQVV		VSRILMAAPG		MAIPPFIMNT
LEKKAFLKRF		PWMSAPIQVG		LVGFCLVFAT		PLCCALFPQK		SSMSVTSLEA
ELQAKIQESH		PELRRVYFNK		GL

Dopunska literatura

• Kaplan RS, Mayor JA (oktobar 1993). "Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria". Journal of Bioenergetics and Biomembranes. 25 (5): 503–14. doi:10.1007/BF01108407. PMID 8132490. S2CID 24848406.
• Hartley JL, Temple GF, Brasch MA (novembar 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (mart 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Fleming MD, Campagna DR, Haslett JN, Trenor CC, Andrews NC (mart 2001). "A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice". Genes & Development. 15 (6): 652–7. doi:10.1101/gad.873001. PMC 312659. PMID 11274051.
• Zara V, Giudetti AM, Siculella L, Palmieri F, Gnoni GV (novembar 2001). "Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats". European Journal of Biochemistry. 268 (22): 5734–9. doi:10.1046/j.0014-2956.2001.02508.x. PMID 11722557.
• Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M (juli 2002). "Identification and characterization of a novel mitochondrial tricarboxylate carrier". Biochemical and Biophysical Research Communications. 295 (2): 463–8. doi:10.1016/S0006-291X(02)00694-0. PMID 12150972.
• Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, Siculella L, Gnoni GV (novembar 2003). "Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria". Journal of Lipid Research. 44 (11): 2135–41. doi:10.1194/jlr.M300237-JLR200. PMID 14634051.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (februar 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Siculella L, Damiano F, Sabetta S, Gnoni GV (juli 2004). "n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms". Journal of Lipid Research. 45 (7): 1333–40. doi:10.1194/jlr.M400061-JLR200. PMID 15060089.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (oktobar 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Siculella L, Sabetta S, Damiano F, Giudetti AM, Gnoni GV (decembar 2004). "Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver". FEBS Letters. 578 (3): 280–4. doi:10.1016/j.febslet.2004.11.014. PMID 15589833. S2CID 24071277.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (januar 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.