SMG7

SMG7
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1YA0
Identifikatori
Aliasi	SMG7
Vanjski ID-jevi	OMIM: 610964 MGI: 2682334 HomoloGene: 32235 GeneCards: SMG7
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	183,598,246 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	152,778,397 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein phosphatase 2A binding; • GO:0001948, GO:0016582 vezivanje za proteine; • telomeric DNA binding; • ribonuclease activity; • ribonucleoprotein complex binding; • telomerase RNA binding;
Ćelijska komponenta	• citoplazma; • intermediate filament cytoskeleton; • jedro; • telomerase holoenzyme complex; • citosol;
Biološki proces	• regulation of dephosphorylation; • Nonsens-posredovano propadanje iRNK; • mRNA export from nucleus; • telomere maintenance via telomerase; • regulation of RNA stability; • RNA phosphodiester bond hydrolysis; • regulation of telomere maintenance via telomerase;
	Izvori:Amigo / QuickGO
Ortolozi
	9887
	226517
	ENSG00000116698
	ENSMUSG00000042772
	Q92540
	Q5RJH6
NM_001174061; NM_014837; NM_173156; NM_201568; NM_201569;
	NM_001331007; NM_001350219; NM_001350220; NM_001350221; NM_001350222; NM_001375584; NM_001375585
	NM_001005507; NM_001160256; NM_001160257; NM_001359257
NP_001167532; NP_001317936; NP_775179; NP_963862; NP_963863;
	NP_001337148; NP_001337149; NP_001337150; NP_001337151; NP_001362513; NP_001362514
	NP_001005507; NP_001153728; NP_001153729; NP_001346186
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein SMG7 jest protein koji je kod ljudi kodiran genom SMG7 sa hromosoma 1.^[5]^[6]^[7]^[8]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.137 aminokiselina, a molekulska 127.282 težina Da.^[9]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSLQSAQYLR	QAEVLKADMT	DSKLGPAEVW	TSRQALQDLY	QKMLVTDLEY
ALDKKVEQDL	WNHAFKNQIT	TLQGQAKNRA	NPNRSEVQAN	LSLFLEAASG
FYTQLLQELC	TVFNVDLPCR	VKSSQLGIIS	NKQTHTSAIV	KPQSSSCSYI
CQHCLVHLGD	IARYRNQTSQ	AESYYRHAAQ	LVPSNGQPYN	QLAILASSKG
DHLTTIFYYC	RSIAVKFPFP	AASTNLQKAL	SKALESRDEV	KTKWGVSDFI
KAFIKFHGHV	YLSKSLEKLS	PLREKLEEQF	KRLLFQKAFN	SQQLVHVTVI
NLFQLHHLRD	FSNETEQHTY	SQDEQLCWTQ	LLALFMSFLG	ILCKCPLQNE
SQEESYNAYP	LPAVKVSMDW	LRLRPRVFQE	AVVDERQYIW	PWLISLLNSF
HPHEEDLSSI	SATPLPEEFE	LQGFLALRPS	FRNLDFSKGH	QGITGDKEGQ
QRRIRQQRLI	SIGKWIADNQ	PRLIQCENEV	GKLLFITEIP	ELILEDPSEA
KENLILQETS	VIESLAADGS	PGLKSVLSTS	RNLSNNCDTG	EKPVVTFKEN
IKTREVNRDQ	GRSFPPKEVR	RDYSKGITVT	KNDGKKDNNK	RKTETKKCTL
EKLQETGKQN	VAVQVKSQTE	LRKTPVSEAR	KTPVTQTPTQ	ASNSQFIPIH
HPGAFPPLPS	RPGFPPPTYV	IPPPVAFSMG	SGYTFPAGVS	VPGTFLQPTA
HSPAGNQVQA	GKQSHIPYSQ	QRPSGPGPMN	QGPQQSQPPS	QQPLTSLPAQ
PTAQSTSQLQ	VQALTQQQQS	PTKAVPALGK	SPPHHSGFQQ	YQQADASKQL
WNPPQVQGPL	GKIMPVKQPY	YLQTQDPIKL	FEPSLQPPVM	QQQPLEKKMK
PFPMEPYNHN	PSEVKVPEFY	WDSSYSMADN	RSVMAQQANI	DRRGKRSPGV
FRPEQDPVPR	MPFEKSLLEK	PSELMSHSSS	FLSLTGFSLN	QERYPNNSMF
NEVYGKNLTS	SSKAELSPSM	APQETSLYSL	FEGTPWSPSL	PASSDHSTPA
SQSPHSSNPS	SLPSSPPTHN	HNSVPFSNFG	PIGTPDNRDR	RTADRWKTDK
PAMGGFGIDY	LSATSSSESS	WHQASTPSGT	WTGHGPSMED	SSAVLMESLK
SIWSSSMMHP	GPSALEQLLM	QQKQKQQRGQ	GTMNPPH

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116698 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042772 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (novembar 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
^ Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (februar 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.
^ "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".
^ Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (juni 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.
^ "UniProt, Q92540" (jezik: engleski). Pristupljeno 19. 12. 2021.

Dopunska literatura[uredi | uredi izvor]

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (juni 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (oktobar 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (april 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics. 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
Reichenbach P, Höss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (april 2003). "A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed". Current Biology. 13 (7): 568–74. doi:10.1016/S0960-9822(03)00173-8. PMID 12676087. S2CID 14423276.
Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (april 2003). "Functional conservation of the telomerase protein Est1p in humans". Current Biology. 13 (8): 698–704. doi:10.1016/S0960-9822(03)00210-0. PMID 12699629. S2CID 6685276.
Unterholzner L, Izaurralde E (novembar 2004). "SMG7 acts as a molecular link between mRNA surveillance and mRNA decay". Molecular Cell. 16 (4): 587–96. doi:10.1016/j.molcel.2004.10.013. PMID 15546618.
Azzalin CM, Lingner J (februar 2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Current Biology. 16 (4): 433–9. doi:10.1016/j.cub.2006.01.018. PMID 16488880. S2CID 17197870.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (novembar 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116698 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042772 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14636577-5] Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, et al. (novembar 2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Molecular Cell. 12 (5): 1187–200. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.

[pmid15721257-6] Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (februar 2005). "SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway". Molecular Cell. 17 (4): 537–47. doi:10.1016/j.molcel.2005.01.010. PMID 15721257.

[entrez-7] "Entrez Gene: SMG7 Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)".

[8] Yang L, Kraft VA, Pfeiffer S, Merl-Pham J, Bao X, An Y, et al. (juni 2020). "Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1". Molecular Oncology. 14 (10): 2420–2435. doi:10.1002/1878-0261.12754. PMC 7530794. PMID 32602581.

[UniProt-9] "UniProt, Q92540" (jezik: engleski). Pristupljeno 19. 12. 2021.

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