STX16

STX16
Identifikatori
Aliasi	STX16
Vanjski ID-jevi	OMIM: 603666 MGI: 1923396 HomoloGene: 2791 GeneCards: STX16
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	58,679,526 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	173,941,564 bp
Ontologija gena
Molekularna funkcija	• SNAP receptor activity; • GO:0001948, GO:0016582 vezivanje za proteine; • syntaxin binding; • SNARE binding;
Ćelijska komponenta	• citoplazma; • integral component of membrane; • Golđijev aparat; • membrana; • intracellular membrane-bounded organelle; • Golgi cisterna; • focal adhesion; • trans-Golđijeva mreža; • SNARE complex; • Endoplazmatski retikulum; • perinuklearno područje citoplazme; • citosol; • trans-Golgi network membrane; • Golđijeva membrana; • Endomembranski sistem; • integral component of synaptic vesicle membrane;
Biološki proces	• vesicle docking; • retrograde transport, endosome to Golgi; • protein transport; • intracellular protein transport; • Fuzija vezikula; • Golgi ribbon formation; • vesicle-mediated transport; • GO:0015915 transport;
	Izvori:Amigo / QuickGO
Ortolozi
	8675
	228960
	ENSG00000124222
	ENSMUSG00000027522
	O14662
	Q8BVI5
NM_001001433; NM_001001434; NM_001134772; NM_001134773; NM_001204868;
	NM_003763
NM_001102423; NM_001102424; NM_001102425; NM_172675; NM_001363029;
	NM_001363030; NM_001363031
	NP_001001433; NP_001128244; NP_001128245; NP_001191797; NP_003754
NP_001095893; NP_001095894; NP_001095895; NP_766263; NP_001349958;
	NP_001349959; NP_001349960
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Sintaksin-16 jest protein koji je kod ljudi kodiran genom STX16 sa hromosoma 20.^[5]^[6]^[7]^[8]

Povezan je sa pseudohipoparatireoidizmom tipa Ib. Gubitak ovog gena uzrokuje gubitak metilacije na egzonu GNAS1 A/B.^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 325 aminokiselina, a molekulska težina 37.031 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATRRLTDAF	LLLRNNSIQN	RQLLAEQVSS	HITSSPLHSR	SIAAELDELA
DDRMALVSGI	SLDPEAAIGV	TKRPPPKWVD	GVDEIQYDVG	RIKQKMKELA
SLHDKHLNRP	TLDDSSEEEH	AIEITTQEIT	QLFHRCQRAV	QALPSRARAC
SEQEGRLLGN	VVASLAQALQ	ELSTSFRHAQ	SGYLKRMKNR	EERSQHFFDT
SVPLMDDGDD	NTLYHRGFTE	DQLVLVEQNT	LMVEEREREI	RQIVQSISDL
NEIFRDLGAM	IVEQGTVLDR	IDYNVEQSCI	KTEDGLKQLH	KAEQYQKKNR
KMLVILILFV	IIIVLIVVLV	GVKSR

Interakcije[uredi | uredi izvor]

Pokazalo se da STX16 reaguje sa VAMP4.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124222 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027522 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.
^ Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.
^ ^a ^b Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.
^ ^a ^b "Entrez Gene: STX16 syntaxin 16".
^ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Dopunska literatura[uredi | uredi izvor]

Yu Y, Zhang C, Zhou G, Wu S, Qu X, Wei H, Xing G, Dong C, Zhai Y, Wan J, Ouyang S, Li L, Zhang S, Zhou K, Zhang Y, Wu C, He F (Aug 2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs". Genome Research. 11 (8): 1392–403. doi:10.1101/gr.175501. PMC 311073. PMID 11483580.
Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, Rizo J (Jul 2002). "How Tlg2p/syntaxin 16 'snares' Vps45". The EMBO Journal. 21 (14): 3620–31. doi:10.1093/emboj/cdf381. PMC 126126. PMID 12110575.
Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M (Dec 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. doi:10.1126/science.1088821. PMID 14671302. S2CID 6682593.
Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W (Sep 2004). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network". Molecular Biology of the Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Amessou M, Fradagrada A, Falguières T, Lord JM, Smith DC, Roberts LM, Lamaze C, Johannes L (Apr 2007). "Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins". Journal of Cell Science. 120 (Pt 8): 1457–68. doi:10.1242/jcs.03436. PMC 1863825. PMID 17389686.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124222 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027522 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9464276-5] Tang BL, Low DY, Lee SS, Tan AE, Hong W (Jan 1998). "Molecular cloning and localization of human syntaxin 16, a member of the syntaxin family of SNARE proteins". Biochemical and Biophysical Research Communications. 242 (3): 673–9. doi:10.1006/bbrc.1997.8029. PMID 9464276.

[pmid9587053-6] Simonsen A, Bremnes B, Rønning E, Aasland R, Stenmark H (Mar 1998). "Syntaxin-16, a putative Golgi t-SNARE". European Journal of Cell Biology. 75 (3): 223–31. doi:10.1016/S0171-9335(98)80116-7. PMID 9587053.

[pmid15800843-7] Linglart A, Gensure RC, Olney RC, Jüppner H, Bastepe M (May 2005). "A novel STX16 deletion in autosomal dominant pseudohypoparathyroidism type Ib redefines the boundaries of a cis-acting imprinting control element of GNAS". American Journal of Human Genetics. 76 (5): 804–14. doi:10.1086/429932. PMC 1199370. PMID 15800843.

[entrez-8] "Entrez Gene: STX16 syntaxin 16".

[pmid11839770-9] Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (Feb 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]