TACC3

TACC3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4LPZ, 4PKY
Identifikatori
Aliasi	TACC3
Vanjski ID-jevi	OMIM: 605303 MGI: 1341163 HomoloGene: 81618 GeneCards: TACC3
Lokacija gena (čovjek)
Hrom.	Hromosom 4 (čovjek)
Kraj	1,745,171 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	33,678,995 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• citoplazma; • microtubule cytoskeleton; • spindle pole; • Diobeno vreteno; • citoskelet; • centar organizacije mikrotubula; • citosol; • mitotic spindle;
Biološki proces	• Ćelijska proliferacija; • cerebral cortex development; • Metafaza; • regulation of mitotic spindle organization; • microtubule cytoskeleton organization involved in mitosis; • ćelijski ciklus; • Ćelijska dioba; • microtubule cytoskeleton organization; • GO:0043148 mitotic spindle organization;
	Izvori:Amigo / QuickGO
Ortolozi
	10460
	21335
	ENSG00000013810
	ENSMUSG00000037313
	Q9Y6A5
	Q9JJ11
	NM_006342
	NM_001040435; NM_011524; NM_001310541
	NP_006333
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Transformirajući kiseli protein 3 sa upredenom zavojnicom jest protein koji je kod ljudi kodiran genom TACC3 sa hromosoma 4.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 838 aminokiselina, a molekulska težina 90.360 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSLQVLNDKN	VSNEKNTENC	DFLFSPPEVT	GRSSVLRVSQ	KENVPPKNLA
KAMKVTFQTP	LRDPQTHRIL	SPSMASKLEA	PFTQDDTLGL	ENSHPVWTQK
ENQQLIKEVD	AKTTHGILQK	PVEADTDLLG	DASPAFGSGS	SSESGPGALA
DLDCSSSSQS	PGSSENQMVS	PGKVSGSPEQ	AVEENLSSYS	LDRRVTPASE
TLEDPCRTES	QHKAETPHGA	EEECKAETPH	GAEEECRHGG	VCAPAAVATS
PPGAIPKEAC	GGAPLQGLPG	EALGCPAGVG	TPVPADGTQT	LTCAHTSAPE
STAPTNHLVA	GRAMTLSPQE	EVAAGQMASS	SRSGPVKLEF	DVSDGATSKR
APPPRRLGER	SGLKPPLRKA	AVRQQKAPQE	VEEDDGRSGA	GEDPPMPASR
GSYHLDWDKM	DDPNFIPFGG	DTKSGCSEAQ	PPESPETRLG	QPAAEQLHAG
PATEEPGPCL	SQQLHSASAE	DTPVVQLAAE	TPTAESKERA	LNSASTSLPT
SCPGSEPVPT	HQQGQPALEL	KEESFRDPAE	VLGTGAEVDY	LEQFGTSSFK
ESALRKQSLY	LKFDPLLRDS	PGRPVPVATE	TSSMHGANET	PSGRPREAKL
VEFDFLGALD	IPVPGPPPGV	PAPGGPPLST	GPIVDLLQYS	QKDLDAVVKA
TQEENRELRS	RCEELHGKNL	ELGKIMDRFE	EVVYQAMEEV	QKQKELSKAE
IQKVLKEKDQ	LTTDLNSMEK	SFSDLFKRFE	KQKEVIEGYR	KNEESLKKCV
EDYLARITQE	GQRYQALKAH	AEEKLQLANE	EIAQVRSKAQ	AEALALQASL
RKEQMRIQSL	EKTVEQKTKE	NEELTRICDD	LISKMEKI

Funkcija[uredi | uredi izvor]

Funkcija ovog gena još nije utvrđena; međutim, spekulira se da može biti uključen u ćelijski rast i diferencijaciju. Ekspresija ovog gena je pojačano regulirana u nekim linijama ćelija raka, a 15. dana kod mišjeg embriona.^[6]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000013810 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037313 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP (Oct 2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J Biol Chem. 282 (40): 29273–83. doi:10.1074/jbc.M704151200. PMID 17675670.
^ ^a ^b "Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3".
^ "UniProt, Q9Y6A5" (jezik: англ.). Pristupljeno 27. 10. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunsla literatura[uredi | uredi izvor]

Lappin TR, Mullan RN, Stewart JP, et al. (2003). "AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains". Leuk. Lymphoma. 43 (7): 1455–9. doi:10.1080/1042819022386644. PMID 12389629. S2CID 2098614.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
McKeveney PJ, Hodges VM, Mullan RN, et al. (2001). "Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells". Br. J. Haematol. 112 (4): 1016–24. doi:10.1046/j.1365-2141.2001.02644.x. PMID 11298601. S2CID 27869385.
Piekorz RP, Hoffmeyer A, Duntsch CD, et al. (2002). "The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis". EMBO J. 21 (4): 653–64. doi:10.1093/emboj/21.4.653. PMC 125348. PMID 11847113.
Steadman BT, Schmidt PH, Shanks RA, et al. (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus". J. Biol. Chem. 277 (33): 30165–76. doi:10.1074/jbc.M201914200. PMID 12015314.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID 12711550.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. CiteSeerX 10.1.1.539.8359. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Gangisetty O, Lauffart B, Sondarva GV, et al. (2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000013810 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037313 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17675670-5] Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP (Oct 2007). "The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival". J Biol Chem. 282 (40): 29273–83. doi:10.1074/jbc.M704151200. PMID 17675670.

[entrez-6] "Entrez Gene: TACC3 transforming, acidic coiled-coil containing protein 3".

[UniProt-7] "UniProt, Q9Y6A5" (jezik: англ.). Pristupljeno 27. 10. 2021.CS1 održavanje: nepoznati jezik (link)

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