THBS3

THBS3
Identifikatori
Aliasi	THBS3
Vanjski ID-jevi	OMIM: 188062 MGI: 98739 HomoloGene: 5159 GeneCards: THBS3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	155,209,051 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	89,134,144 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• calcium ion binding; • heparin binding; • extracellular matrix structural constituent;
Ćelijska komponenta	• perinuklearno područje citoplazme; • extracellular region; • GO:0005578 Vanćelijski matriks; • Vanćelijsko; • collagen-containing extracellular matrix;
Biološki proces	• growth plate cartilage development; • ossification involved in bone maturation; • cell-matrix adhesion; • Ćelijska adhezija; • bone trabecula formation; • extracellular matrix organization;
	Izvori:Amigo / QuickGO
Ortolozi
	7059
	21827
	ENSG00000169231
	ENSMUSG00000028047
	P49746
	Q05895
	NM_001252607; NM_001252608; NM_007112
	NM_013691
	NP_001239536; NP_001239537; NP_009043
	NP_038719
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Trombospondin-3 (TSP3) jest protein koji je kod ljudi kodiran genom THBS3 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 956 aminokiselina, a molekulska težina 104.201 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
METQELRGAL	ALLLLCFFTS	ASQDLQVIDL	LTVGESRQMV	AVAEKIRTAL
LTAGDIYLLS	TFRLPPKQGG	VLFGLYSRQD	NTRWLEASVV	GKINKVLVRY
QREDGKVHAV	NLQQAGLADG	RTHTVLLRLR	GPSRPSPALH	LYVDCKLGDQ
HAGLPALAPI	PPAEVDGLEI	RTGQKAYLRM	QGFVESMKII	LGGSMARVGA
LSECPFQGDE	SIHSAVTNAL	HSILGEQTKA	LVTQLTLFNQ	ILVELRDDIR
DQVKEMSLIR	NTIMECQVCG	FHEQRSHCSP	NPCFRGVDCM	EVYEYPGYRC
GPCPPGLQGN	GTHCSDINEC	AHADPCFPGS	SCINTMPGFH	CEACPRGYKG
TQVSGVGIDY	ARASKQVCND	IDECNDGNNG	GCDPNSICTN	TVGSFKCGPC
RLGFLGNQSQ	GCLPARTCHS	PAHSPCHIHA	HCLFERNGAV	SCQCNVGWAG
NGNVCGTDTD	IDGYPDQALP	CMDNNKHCKQ	DNCLLTPNSG	QEDADNDGVG
DQCDDDADGD	GIKNVEDNCR	LFPNKDQQNS	DTDSFGDACD	NCPNVPNNDQ
KDTDGNGEGD	ACDNDVDGDG	IPNGLDNCPK	VPNPLQTDRD	EDGVGDACDS
CPEMSNPTQT	DADSDLVGDV	CDTNEDSDGD	GHQDTKDNCP	QLPNSSQLDS
DNDGLGDECD	GDDDNDGIPD	YVPPGPDNCR	LVPNPNQKDS	DGNGVGDVCE
DDFDNDAVVD	PLDVCPESAE	VTLTDFRAYQ	TVVLDPEGDA	QIDPNWVVLN
QGMEIVQTMN	SDPGLAVGYT	AFNGVDFEGT	FHVNTVTDDD	YAGFLFSYQD
SGRFYVVMWK	QTEQTYWQAT	PFRAVAQPGL	QLKAVTSVSG	PGEHLRNALW
HTGHTPDQVR	LLWTDPRNVG	WRDKTSYRWQ	LLHRPQVGYI	RVKLYEGPQL
VADSGVIIDT	SMRGGRLGVF	CFSQENIIWS	NLQYRCNDTV	PEDFEPFRRQ
LLQGRV

Funkcija[uredi | uredi izvor]

Protein kodiran ovim genom pripada porodici trombospondina. Članovi porodice trombospondina su adhezivni glikoproteini koji posreduju u interakcijama ćelija-ćelija i ćelija-matriks. Utvrđeno je da je TSP3 uključen u regulaciju sazrijevanja skeleta.^[8] Ovaj protein formira pentamernu molekulu povezanu jednom disulfidnom vezom. Ovaj gen dijeli zajednički promotor s metaksinom 1.^[6] Identificiran je kao gen na hromosomu 1, odgovoran za posredovanje vze s genetskičm osjetljivošću na infekcije SARS-CoV-2.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.
^ ^a ^b "Entrez Gene: THBS3 thrombospondin 3".
^ "UniProt, P49746" (jezik: engleski). Pristupljeno 20. 12. 2017.
^ Hankenson, Kurt (juli 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.
^ "Mapping the human genetic architecture of COVID-19". Nature. juli 2021. doi:10.1038/s41586-021-03767-x. PMID 34237774 Provjerite vrijednost parametra |pmid= (pomoć). S2CID 235776838 Provjerite vrijednost parametra |s2cid= (pomoć).

Dopunsdka literatura[uredi | uredi izvor]

O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers". J. Biol. Chem. 267 (35): 24921–4. doi:10.1016/S0021-9258(19)73983-0. PMID 1459996.
Adolph KW, Long GL, Winfield S, et al. (1995). "Structure and organization of the human thrombospondin 3 gene (THBS3)". Genomics. 27 (2): 329–36. doi:10.1006/geno.1995.1050. PMID 7558000.
Qabar A, Derick L, Lawler J, Dixit V (1995). "Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues". J. Biol. Chem. 270 (21): 12725–9. doi:10.1074/jbc.270.21.12725. PMID 7759526.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Qabar AN, Lin Z, Wolf FW, et al. (1994). "Thrombospondin 3 is a developmentally regulated heparin binding protein". J. Biol. Chem. 269 (2): 1262–9. doi:10.1016/S0021-9258(17)42252-6. PMID 8288588.
Bornstein P, Devarayalu S, Edelhoff S, Disteche CM (1993). "Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene". Genomics. 15 (3): 607–13. doi:10.1006/geno.1993.1114. PMID 8468055.
Winfield SL, Tayebi N, Martin BM, et al. (1997). "Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease". Genome Res. 7 (10): 1020–6. doi:10.1101/gr.7.10.1020. PMC 310674. PMID 9331372.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
Adolph KW, Bornstein P (2000). "The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript". Mol. Cell Biol. Res. Commun. 2 (1): 47–52. doi:10.1006/mcbr.1999.0148. PMID 10527891.
Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4". Int. J. Biochem. Cell Biol. 32 (11–12): 1137–42. doi:10.1016/S1357-2725(00)00065-0. PMID 11137453.
Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype". Int. J. Biochem. Cell Biol. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dalla-Torre CA, Yoshimoto M, Lee CH, et al. (2006). "Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma". BMC Cancer. 6: 237. doi:10.1186/1471-2407-6-237. PMC 1609181. PMID 17022822.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169231 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028047 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1601886-5] Vos HL, Devarayalu S, de Vries Y, Bornstein P (Jul 1992). "Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family". J Biol Chem. 267 (17): 12192–6. doi:10.1016/S0021-9258(19)49823-2. PMID 1601886.

[entrez-6] "Entrez Gene: THBS3 thrombospondin 3".

[UniProt-7] "UniProt, P49746" (jezik: engleski). Pristupljeno 20. 12. 2017.

[8] Hankenson, Kurt (juli 2005). "Mice with a Disruption of the Thrombospondin 3 Gene Differ in Geometric and Biomechanical Properties of Bone and Have Accelerated Development of the Femoral Head". Molecular and Cellular Biology. 25 (13): 5599–5606. doi:10.1128/MCB.25.13.5599-5606.2005. PMC 1156967. PMID 15964815.

[9] "Mapping the human genetic architecture of COVID-19". Nature. juli 2021. doi:10.1038/s41586-021-03767-x. PMID 34237774 Provjerite vrijednost parametra |pmid= (pomoć). S2CID 235776838 Provjerite vrijednost parametra |s2cid= (pomoć).

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