THRSP
Tiroidnim hormonom inducibilni jetreni protein je protein koji je kod ljudi kodiran genom THRSP.[5][6]
Protein kodiran ovim genom sličan je genskom proizvodu S14, pacovskog gena, čija je ekspresija ograničena na jetru i masno tkivo i kontrolirana je nutritivnim i hormonskim faktorima.
Pokazalo se da se ovaj gen eksprimira u jetri i adipocitima, posebno u lipomskim modulima. Također je utvrđeno da se eksprimira u lipogenom raku dojke, što ukazuje na ulogu u tumorskoj kontroli metabolizma lipida.[6]
Ranije je THRSP bio među identificiranim reguliranim genima u prefrontalnom korteksu spontano hipertenzivnih pacova (SHR/NCrl) i Wistar-Kyoto (WKY/NCrl) pacova koji su pokazivali ponašanje nepažnje.[7] Nakon toga, prekomjerna ekspresija THRSP-a izazvala je nepažnju, ali ne i hiperaktivno i impulzivno ponašanje miševa, što ukazuje na to da ovaj gen ima ulogu u fenotipu obilježenom nepažnjom ADHD -a.[8]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 146 aminokiselina, а molekulska težina 16.561 Da.[9].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MQVLTKRYPK | NCLLTVMDRY | AAEVHNMEQV | VMIPSLLRDV | QLSGPGGQAQ | ||||
| AEAPDLYTYF | TMLKAICVDV | DHGLLPREEW | QAKVAGSEEN | GTAETEEVED | ||||
| ESASGELDLE | AQFHLHFSSL | HHILMHLTEK | AQEVTRKYQE | MTGQVW |
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000151365 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035686 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, Torresani J, Planells R (Feb 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Lett. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.
- ^ a b "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".
- ^ dela Peña, Ike; Bang, Minji; Lee, Jinhee; de la Peña, June Bryan; Kim, Bung-Nyun; Han, Doug Hyun; Noh, Minsoo; Shin, Chan Young; Cheong, Jae Hoon (septembar 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research (jezik: engleski). 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.
- ^ Custodio, Raly James Perez; Botanas, Chrislean Jun; de la Peña, June Bryan; dela Peña, Irene Joy; Kim, Mikyung; Sayson, Leandro Val; Abiero, Arvie; Ryoo, Zae Young; Kim, Bung-Nyun; Kim, Hee Jin; Cheong, Jae Hoon (oktobar 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience (jezik: engleski). 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.
- ^ "UniProt, Q92748". Pristupljeno 27. 8. 2021.
Dopunska literatura[uredi | uredi izvor]
- Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB (1998). ""Spot 14" protein: a metabolic integrator in normal and neoplastic cells". Thyroid. 8 (9): 815–25. doi:10.1089/thy.1998.8.815. PMID 9777755.
- Ota Y, Mariash A, Wagner JL, Mariash CN (1997). "Cloning, expression and regulation of the human S14 gene". Mol. Cell. Endocrinol. 126 (1): 75–81. doi:10.1016/S0303-7207(96)03971-8. PMID 9027365. S2CID 22056127.
- Taviaux S, Planells R, Gastaldi M, et al. (1997). "Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5→q14.1 by in situ hybridization". Cytogenet. Cell Genet. 76 (3–4): 219–20. doi:10.1159/000134553. PMID 9186528.
- Moncur JT, Park JP, Maloney M, et al. (1997). "Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization". Cytogenet. Cell Genet. 78 (2): 131–2. doi:10.1159/000134644. PMID 9371405.
- Cunningham BA, Maloney M, Kinlaw WB (1997). "Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo". Endocrinology. 138 (12): 5184–8. doi:10.1210/en.138.12.5184. PMID 9389499.
- Moncur JT, Park JP, Memoli VA, et al. (1998). "The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6989–94. Bibcode:1998PNAS...95.6989M. doi:10.1073/pnas.95.12.6989. PMC 22712. PMID 9618526.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Campbell MC, Anderson GW, Mariash CN (2004). "Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification". Endocrinology. 144 (12): 5242–8. doi:10.1210/en.2002-0008. PMID 12960053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Chou WY, Cheng YS, Ho CL, et al. (2007). "Human spot 14 protein interacts physically and functionally with the thyroid receptor". Biochem. Biophys. Res. Commun. 357 (1): 133–8. doi:10.1016/j.bbrc.2007.03.103. PMID 17418816.