UCN2
Urokortin-2 jest protein koji je kod ljudi kodiran genom UCN2 sa hromosoma 3.[5][6]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 112 aminokiselina, а molekulska težina 12.146 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTRCALLLLM | VLMLGRVLVV | PVTPIPTFQL | RPQNSPQTTP | RPAASESPSA | ||||
| APTWPWAAQS | HCSPTRHPGS | RIVLSLDVPI | GLLQILLEQA | RARAAREQAT | ||||
| TNARILARVG | HC |
Funkcija[uredi | uredi izvor]
Ovaj gen je član porodice sauvagin/kortikotropin-oslobađajući faktor/urotenzina I. Strukturno je povezan sa faktorom oslobađanja kortikotropina (CRF) genom. Kodirani proizvod je endogeni ligand za receptore CRF tipa 2. U mozgu može biti odgovoran za efekte stresa na apetit. Uprkos sličnosti u imenima gena, proizvod ovog gena nema sličnost sekvence sa urotenzinom II.[6]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000145040 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049699 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hsu SY, Hsueh AJ (Apr 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nat Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. S2CID 22916906.
- ^ a b "Entrez Gene: UCN2 urocortin 2".
- ^ "UniProt, Q96RP3" (jezik: engleski). Pristupljeno 6. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Hauger RL, Grigoriadis DE, Dallman MF, et al. (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952. S2CID 1572317.
- Florio P, Torres PB, Torricelli M, et al. (2006). "Human endometrium expresses urocortin II and III messenger RNA and peptides". Fertil. Steril. 86 (6): 1766–70. doi:10.1016/j.fertnstert.2006.05.041. PMID 17074339.
- Imperatore A, Florio P, Torres PB, et al. (2006). "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes". Am. J. Obstet. Gynecol. 195 (1): 288–95. doi:10.1016/j.ajog.2005.12.048. PMID 16626608.
- Isfort RJ, Wang F, Tscheiner M, et al. (2006). "Modifications of the human urocortin 2 peptide that improve pharmacological properties". Peptides. 27 (7): 1806–13. doi:10.1016/j.peptides.2006.01.003. PMID 16476507. S2CID 41513209.
- Czimmer J, Million M, Taché Y (2006). "Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (3): G511–8. doi:10.1152/ajpgi.00289.2005. PMID 16223946.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chang CL, Hsu SY (2005). "Ancient evolution of stress-regulating peptides in vertebrates". Peptides. 25 (10): 1681–8. doi:10.1016/j.peptides.2004.05.022. PMID 15476935. S2CID 25716793.
- Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950.
- Chanalaris A, Lawrence KM, Stephanou A, et al. (2004). "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes". J. Mol. Cell. Cardiol. 35 (10): 1295–305. doi:10.1016/S0022-2828(03)00244-X. PMID 14519439.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. Bibcode:2001PNAS...98.7570L. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
- Reyes TM, Lewis K, Perrin MH, et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. Bibcode:2001PNAS...98.2843R. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328.