VAV3

VAV3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2D86
Identifikatori
Aliasi	VAV3
Vanjski ID-jevi	OMIM: 605541 MGI: 1888518 HomoloGene: 38143 GeneCards: VAV3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	107,965,180 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	109,593,014 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje iona metala; • epidermal growth factor receptor binding; • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity; • guanyl-nucleotide exchange factor activity;
Ćelijska komponenta	• citoplazma; • citosol; • ćelijska membrana;
Biološki proces	• Angiogeneza; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:0007243 intracellular signal transduction; • ephrin receptor signaling pathway; • lamellipodium assembly; • regulation of Rho protein signal transduction; • positive regulation of phosphatidylinositol 3-kinase activity; • vascular endothelial growth factor receptor signaling pathway; • small GTPase mediated signal transduction; • B cell receptor signaling pathway; • cell projection assembly; • Fc-epsilon receptor signaling pathway; • positive regulation of apoptotic process; • integrin-mediated signaling pathway; • cellular response to DNA damage stimulus; • regulation of cell size; • regulation of small GTPase mediated signal transduction; • Ćelijska migracija; • platelet activation; • Fuzija vezikula; • positive regulation of cell adhesion; • positive regulation of B cell proliferation; • neutrophil chemotaxis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • positive regulation of signal transduction; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • G protein-coupled receptor signaling pathway;
	Izvori:Amigo / QuickGO
Ortolozi
	10451
	57257
	ENSG00000134215
	ENSMUSG00000033721
	Q9UKW4
	Q9R0C8
	NM_001079874; NM_006113
	NM_020505; NM_146139; NM_001378987
	NP_001073343; NP_006104
	NP_065251; NP_666251; NP_001365916
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Guanin-nukleotidni izmjenjivački faktor VAV3 jest protein koji je kod ljudi kodiran genom VAV3 sa hromosoma 1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 847 aminokiselina, a molekulska težina 97.776 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MEPWKQCAQW	LIHCKVLPTN	HRVTWDSAQV	FDLAQTLRDG	VLLCQLLNNL
RAHSINLKEI	NLRPQMSQFL	CLKNIRTFLT	ACCETFGMRK	SELFEAFDLF
DVRDFGKVIE	TLSRLSRTPI	ALATGIRPFP	TEESINDEDI	YKGLPDLIDE
TLVEDEEDLY	DCVYGEDEGG	EVYEDLMKAE	EAHQPKCPEN	DIRSCCLAEI
KQTEEKYTET	LESIEKYFMA	PLKRFLTAAE	FDSVFINIPE	LVKLHRNLMQ
EIHDSIVNKN	DQNLYQVFIN	YKERLVIYGQ	YCSGVESAIS	SLDYISKTKE
DVKLKLEECS	KRANNGKFTL	RDLLVVPMQR	VLKYHLLLQE	LVKHTTDPTE
KANLKLALDA	MKDLAQYVNE	VKRDNETLRE	IKQFQLSIEN	LNQPVLLFGR
PQGDGEIRIT	TLDKHTKQER	HIFLFDLAVI	VCKRKGDNYE	MKEIIDLQQY
KIANNPTTDK	ENKKWSYGFY	LIHTQGQNGL	EFYCKTKDLK	KKWLEQFEMA
LSNIRPDYAD	SNFHDFKMHT	FTRVTSCKVC	QMLLRGTFYQ	GYLCFKCGAR
AHKECLGRVD	NCGRVNSGEQ	GTLKLPEKRT	NGLRRTPKQV	DPGLPKMQVI
RNYSGTPPPA	LHEGPPLQLQ	AGDTVELLKG	DAHSLFWQGR	NLASGEVGFF
PSDAVKPCPC	VPKPVDYSCQ	PWYAGAMERL	QAETELINRV	NSTYLVRHRT
KESGEYAISI	KYNNEAKHIK	ILTRDGFFHI	AENRKFKSLM	ELVEYYKHHS
LKEGFRTLDT	TLQFPYKEPE	HSAGQRGNRA	GNSLLSPKVL	GIAIARYDFC
ARDMRELSLL	KGDVVKIYTK	MSANGWWRGE	VNGRVGWFPS	TYVEEDE

Funkcija[uredi | uredi izvor]

Ovaj gen je član porodice gena VAV. VAV proteini su faktori izmjene guaninskih nukleotida (GEF) za porodice Rho GTPaza, koji aktiviraju puteve do preuređivanja aktinskih citoskeleta i transkripcijskih promjena. Ovaj genski proizvod djeluje kao GEF prvenstveno za RhoG, RhoA, I u manjoj mjeri, RAC1, i maksimalno se povezuje sa beznukleotidnim stanjima ovih GTPaza. Za ovaj gen su opisane alternativno prerađene varijante transkripta koje kodiraju različite izoforme.^[5]

Interakcije[uredi | uredi izvor]

Pokazalo se da VAV3 reaguje sa Grb2.^[7]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134215 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033721 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: VAV3 vav 3 oncogene".
^ "UniProt, Q9UKW4" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)
^ Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (mart 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
^ Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (decembar 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.

Dopunska literatura[uredi | uredi izvor]

Hobert O, Schilling JW, Beckerle MC, et al. (1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): 1577–81. PMID 8622875.
Tamma SM, Chirmule N, Yagura H, et al. (1997). "CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells". Blood. 90 (4): 1588–93. doi:10.1182/blood.V90.4.1588. PMID 9269777.
Trenkle T, Welsh J, Jung B, et al. (1998). "Non-stoichiometric reduced complexity probes for cDNA arrays". Nucleic Acids Res. 26 (17): 3883–3891. doi:10.1093/nar/26.17.3883. PMC 147802. PMID 9705494.
Movilla N, Bustelo XR (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". Mol. Cell. Biol. 19 (11): 7870–85. doi:10.1128/mcb.19.11.7870. PMC 84867. PMID 10523675.
Trenkle T, McClelland M, Adlkofer K, Welsh J (2000). "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors". Gene. 245 (1): 139–149. doi:10.1016/S0378-1119(00)00026-3. PMID 10713454.
Zeng L, Sachdev P, Yan L, et al. (2001). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. PMC 102179. PMID 11094073.
Inabe K, Ishiai M, Scharenberg AM, et al. (2002). "Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation". J. Exp. Med. 195 (2): 189–200. doi:10.1084/jem.20011571. PMC 2193613. PMID 11805146.
Yabana N, Shibuya M (2002). "Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity". Oncogene. 21 (50): 7720–7729. doi:10.1038/sj.onc.1205927. PMID 12400014.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Zakaria S, Gomez TS, Savoy DN, et al. (2004). "Differential regulation of TCR-mediated gene transcription by Vav family members". J. Exp. Med. 199 (3): 429–434. doi:10.1084/jem.20031228. PMC 2211790. PMID 14757747.
Pearce AC, Senis YA, Billadeau DD, et al. (2005). "Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen". J. Biol. Chem. 279 (52): 53955–53962. doi:10.1074/jbc.M410355200. PMID 15456756.
Charvet C, Canonigo AJ, Billadeau DD, Altman A (2005). "Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76". J. Biol. Chem. 280 (15): 15289–15299. doi:10.1074/jbc.M500275200. PMID 15708849.
Lyons LS, Burnstein KL (2006). "Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity". Mol. Endocrinol. 20 (5): 1061–1072. doi:10.1210/me.2005-0346. PMID 16384856.
Dong Z, Liu Y, Lu S, et al. (2006). "Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer". Mol. Endocrinol. 20 (10): 2315–2325. doi:10.1210/me.2006-0048. PMID 16762975.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134215 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033721 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: VAV3 vav 3 oncogene".

[UniProt-6] "UniProt, Q9UKW4" (jezik: eng.). Pristupljeno 29. 11. 2021.CS1 održavanje: nepoznati jezik (link)

[pmid12577067-7] Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (mart 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.

[pmid11094073-8] Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (decembar 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.

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