ZNF160

ZNF160
Identifikatori
Aliasi	ZNF160
Vanjski ID-jevi	OMIM: 600398 HomoloGene: 131121 GeneCards: ZNF160
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	53,103,434 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• vezivanje sa DNK; • vezivanje iona metala; • nucleic acid binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• intracellular anatomical structure; • jedro;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • Hematopoeza;
	Izvori:Amigo / QuickGO
Ortolozi
	90338
	n/a
	ENSG00000170949
	n/a
	Q9HCG1
	n/a
NM_001102603; NM_033288; NM_198893; NM_001322125; NM_001322126;
	NM_001322128; NM_001322129; NM_001322130; NM_001322131; NM_001322132; NM_001322133; NM_001322134; NM_001322135; NM_001322136; NM_001322137; NM_001322138; NM_001322139
	n/a
NP_001096073; NP_001309054; NP_001309055; NP_001309057; NP_001309058;
	NP_001309059; NP_001309060; NP_001309061; NP_001309062; NP_001309063; NP_001309064; NP_001309065; NP_001309066; NP_001309067; NP_001309068; NP_150630; NP_942596
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek

Proteim 160 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF160 .^[3]^[4]^[5]

Protein koji kodiran ovim genom je protein cinkovog prsta povezan sa Krüppelom, koji se odlikuje prisustvom N-terminalnog represorskog domena, Kruppel-vezanog boksa (KRAB). KRAB-ov domen je moćan represor transkripcije; stoga ovaj protein može funkcionisati u regulaciji transkripcije. Opisana su dva alternativna transkripta koji kodiraju istu izoformu.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170949 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4". Genomics. 25 (1): 322–3. doi:10.1016/0888-7543(95)80149-G. PMID 7774943.
^ Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
^ ^a ^b "Entrez Gene: ZNF160 zinc finger protein 160".

Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mark C, Looman C, Abrink M, Hellman L (2001). "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19". DNA Cell Biol. 20 (5): 275–86. doi:10.1089/104454901750232472. PMID 11410164.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.