ZNF878

ZNF878
Identifikatori
Aliasi	ZNF878
Vanjski ID-jevi	MGI: 2684459 HomoloGene: 135689 GeneCards: ZNF878
Lokacija gena (čovjek)
Hrom.	Hromosom 19 (čovjek)
Kraj	12,052,961 bp
Lokacija gena (miš)
Hrom.	Hromosom 8 (miš)
Kraj	72,688,473 bp
Ontologija gena
Molekularna funkcija	• nucleic acid binding; • vezivanje iona metala; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Ćelijska komponenta	• jedro; • intracellular anatomical structure;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II;
	Izvori:Amigo / QuickGO
Ortolozi
	729747
	170938
	ENSG00000257446
	ENSMUSG00000066880
	C9JN71
	n/a
	NM_001080404
	NM_133358
	NP_001073873
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 878 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF878.^[5]^[6]

Pokazatelji egzonskih obilježja[uredi | uredi izvor]

Struktura egzona (Ensembl)^[7]	Egzonski ID	Start egzona	Kraj egzona
ENSG00000257446	ENSG00000257446	ENSG00000257446	ENSG00000257446
ENSE00003544954	ENSE00003476818	ENSE00003499367	ENSE00002351857
12043805	12046368	12046634	12052799
12045209	12046428	12046760	12052939

Interakcije[uredi | uredi izvor]

Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000257446 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066880 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marine JC, Bellefroid EJ, Bourguignon C, Riviere M, Lecoq PJ, Poncelet DA, Szpirer J, Martial JA, Szpirer C (Oct 1994). "Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4". Genomics. 21 (1): 285–6. doi:10.1006/geno.1994.1262. PMID 8088807.
^ "Entrez Gene: ZNF83 zinc finger protein 83".
^ https://www.genecards.org/cgi-bin/carddisp.pl?gene=GeneLoc Integrated Map for Chromosome 19: Exon structure for ZNF878 (weizmann.ac.il)

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000257446 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066880 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8088807-5] Marine JC, Bellefroid EJ, Bourguignon C, Riviere M, Lecoq PJ, Poncelet DA, Szpirer J, Martial JA, Szpirer C (Oct 1994). "Assignment of the human ZNF83 (HPF1) zinc finger gene to chromosome 19q13.3-q13.4". Genomics. 21 (1): 285–6. doi:10.1006/geno.1994.1262. PMID 8088807.

[entrez-6] "Entrez Gene: ZNF83 zinc finger protein 83".

[7] ttps://www.genecards.org/cgi-bin/carddisp.pl?gene=GeneLoc Integrated Map for Chromosome 19: Exon structure for ZNF878 (weizmann.ac.il)

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