FGFRL1
Receptoliki fibroblastni faktor rasta 1 jest protein koji je kod ljudi kodiran genom sa hromosoma 4.[5]
Aminokiselinska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 504 aminokiselina, а molekulska težina 54.537 Da.[6].
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MTPSPLLLLL | LPPLLLGAFP | PAAAARGPPK | MADKVVPRQV | ARLGRTVRLQ | ||||
| CPVEGDPPPL | TMWTKDGRTI | HSGWSRFRVL | PQGLKVKQVE | REDAGVYVCK | ||||
| ATNGFGSLSV | NYTLVVLDDI | SPGKESLGPD | SSSGGQEDPA | SQQWARPRFT | ||||
| QPSKMRRRVI | ARPVGSSVRL | KCVASGHPRP | DITWMKDDQA | LTRPEAAEPR | ||||
| KKKWTLSLKN | LRPEDSGKYT | CRVSNRAGAI | NATYKVDVIQ | RTRSKPVLTG | ||||
| THPVNTTVDF | GGTTSFQCKV | RSDVKPVIQW | LKRVEYGAEG | RHNSTIDVGG | ||||
| QKFVVLPTGD | VWSRPDGSYL | NKLLITRARQ | DDAGMYICLG | ANTMGYSFRS | ||||
| AFLTVLPDPK | PPGPPVASSS | SATSLPWPVV | IGIPAGAVFI | LGTLLLWLCQ | ||||
| AQKKPCTPAP | APPLPGHRPP | GTARDRSGDK | DLPSLAALSA | GPGVGLCEEH | ||||
| GSPAAPQHLL | GPGPVAGPKL | YPKLYTDIHT | HTHTHSHTHS | HVEGKVHQHI | ||||
| HYQC |
Funkcija[uredi | uredi izvor]
Protein kodiran ovim genom je član porodice receptor faktora rasta fibroblasta (FGFR), gdje je sekvenca aminokiselina visoko konzervirana između članova i tokom evolucije. Članovi porodice FGFR razlikuju se međusobno po afinitetima liganda i tkivnoj distribuciji. Reprezentativni protein pune dužine sastojao bi se od vanćelijskog regiona, sastavljenog od tri domena slična imunoglobulinu, jednog hidrofobnog segmenta koji pokriva membranu i domena citoplazmatske tirozin-kinaze. Vanćelijski dio proteina stupa u interakciju s faktorima rasta fibroblasta, pokrećući kaskadu nizvodnih signala, na kraju utičući na mitogenezu i diferencijaciju. Značajna razlika između ovog genskog proizvoda i ostalih članova porodice je nedostatak domena citoplazmatske tirozin-kinaze. Rezultat je transmembranski receptor koji može stupiti u interakciju s drugim članovima porodice i potencijalno inhibirati signalizaciju. Za ovaj gen pronađene su višestruke alternativno prerađene varijante transkripta koje kodiraju istu izoformu.[5]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127418 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008090 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: FGFRL1 fibroblast growth factor receptor-like 1".
- ^ "UniProt, Q8N441" (jezik: engleski). Pristupljeno 28. 10. 2021.
Dopunska literatura[uredi | uredi izvor]
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- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Wiedemann M, Trueb B (2001). "Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors". Genomics. 69 (2): 275–279. doi:10.1006/geno.2000.6332. PMID 11031111.
- Kim I, Moon S, Yu K, et al. (2001). "A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1)". Biochim. Biophys. Acta. 1518 (1–2): 152–6. doi:10.1016/s0167-4781(00)00282-7. PMID 11267671.
- Sleeman M, Fraser J, McDonald M, et al. (2001). "Identification of a new fibroblast growth factor receptor, FGFR5". Gene. 271 (2): 171–182. doi:10.1016/S0378-1119(01)00518-2. PMID 11418238.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Trueb B, Zhuang L, Taeschler S, Wiedemann M (2003). "Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues". J. Biol. Chem. 278 (36): 33857–33865. doi:10.1074/jbc.M300281200. PMID 12813049.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Antoine M, Wirz W, Tag CG, et al. (2005). "Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells". Growth Factors. 23 (2): 87–95. doi:10.1080/08977190500096004. PMID 16019430. S2CID 27380246.
- Schild C, Trueb B (2006). "Aberrant expression of FGFRL1, a novel FGF receptor, in ovarian tumors". Int. J. Mol. Med. 16 (6): 1169–73. doi:10.3892/ijmm.16.6.1169. PMID 16273302.