HLA-DRB3

HLA-DRB3
Dostupne strukture PDB Pretraga Human UniProta: PDBe RCSB Spisak PDB ID kodova 2Q6W, 4H1L
Identifikatori
Aliasi	HLA-DRB3
Vanjski ID-jevi	OMIM: 612735 GeneCards: HLA-DRB3
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • peptide antigen binding • MHC class II receptor activity Ćelijska komponenta • integral component of membrane • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane • endozom • Golđijev aparat • trans-Golgi network membrane • endoplasmic reticulum membrane • membrana • late endosome membrane • Golđijeva membrana • ćelijska membrana • transport vesicle membrane • integral component of plasma membrane • MHC class II protein complex • lysosomal membrane • Endoplazmatski retikulum • ER to Golgi transport vesicle membrane • Lizozom • integral component of lumenal side of endoplasmic reticulum membrane • endosome membrane Biološki proces • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class II • interferon-gamma-mediated signaling pathway • immune system process • T cell costimulation • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor • T cell receptor signaling pathway • GO:0072468 Transdukcija signala • adaptive immune response Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	3125	n/a
Ensembl	n/a	n/a
UniProt	P79483	n/a
RefSeq (mRNK)	NM_022555	n/a
RefSeq (bjelančevina)	NP_072049	n/a
Lokacija (UCSC)	n/a	n/a
PubMed pretraga		n/a
Wikipodaci
Pogledaj/uredi – čovjek

DRB3-1 beta lanac HLA klase II antigena histokompatibilmosti jest protein koji je kod ljudi kodiran genom HLA-DRB3 sa hromosoma 6.

Funkcija

Protein kodiran ovim genom pripada HLA klasi II beta lanca paraloga. Molekula klase II je heterodimer koji se sastoji od alfa (DRA) i beta lanca (DRB), oba usidrena u membrani. Ima centralnu ulogu u imunskom sistemu prezentirajući peptide izvedene iz vanćelijskih proteina. Molekule klase II eksprimirane su u ćelijama koje prezentiraju antigen (APC: B-limfociti, dendritske ćelije, makrofagi).

Struktura gena i polimorfizmi

Beta lanac je otprilike 26-28 kDa. Kodira ga šest egzona; egzon 1 kodira vodeći peptid, egzoni 2 i 3 kodiraju dva ekstracelularna domena, egzon 4 kodira transmembranski domen i egzon 5 kodira citoplazmatski rep. Unutar DR molekula, beta lanac sadrži sve polimorfizme koji određuju specifičnosti vezivanja peptida. Tipizacija za ove polimorfizme radi se rutinski za transplantaciju koštane srži i transplantaciju bubrega.

Ekspresija gena

DRB1 eksprimiran je na nivou pet puta većem od njegovih paraloga DRB3, DRB4 i DRB5. DRB1 je prisutan kod svih osobaa. Alelne varijante DRB1 su povezane ni sa jednim ili sa jednim od gena DRB3, DRB4 i DRB5. Postoje četiri srodna pseudogena: DRB2, DRB6, DRB7, DRB8 i DRB9.

Također pogledajte

• HLA-DR

Dopunska literatura

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