MALL
MAL-liki protein jest protein koji je kod ljudi kodiran genom MALL sa hromosoma 2.[5][6]
Amiokiselininska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 153 aminokiseline, a molekulska težina 17.350 Da.[7]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MASPDPPATS | YAPSDVPSGV | ALFLTIPFAF | FLPELIFGFL | VWTMVAATHI | ||||
| VYPLLQGWVM | YVSLTSFLIS | LMFLLSYLFG | FYKRFESWRV | LDSLYHGTTG | ||||
| ILYMSAAVLQ | VHATIVSEKL | LDPRIYYINS | AASFFAFIAT | LLYILHAFSI | ||||
| YYH |
Funkcija[uredi | uredi izvor]
Ovaj gen kodira element mehanizma za promet endotelnih ćelija posredovan premosnicom. Kodirani protein, član porodice proteolipida MAL, nalazi se pretežno u membranama obogaćenim glikolipidima i holesterolom (GEM). U interakciji je sa kaveolinom-1.[6]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144063 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027377 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hildebrandt F, Otto E, Rensing C, Nothwang HG, Vollmer M, Adolphs J, Hanusch H, Brandis M (Nov 1997). "A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1". Nat Genet. 17 (2): 149–53. doi:10.1038/ng1097-149. PMID 9326933. S2CID 38035697.
- ^ a b "Entrez Gene: MALL mal, T-cell differentiation protein-like".
- ^ "UniProt, Q13021" (jezik: engleski). Pristupljeno 17. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Kurdina MI, Denisov LE (1993). "[An evaluation of the efficacy of dispensary care as a method for the active detection of skin melanoma]". Klinicheskaia Meditsina. 70 (11–12): 68–70. PMID 1294831.
- Lautner-Rieske A, Thiebe R, Zachau HG (1995). "Searching for non-V kappa transcripts from the human immunoglobulin kappa locus". Gene. 159 (2): 199–202. doi:10.1016/0378-1119(95)00161-X. PMID 7622049.
- Magyar JP, Ebensperger C, Schaeren-Wiemers N, Suter U (1997). "Myelin and lymphocyte protein (MAL/MVP17/VIP17) and plasmolipin are members of an extended gene family". Gene. 189 (2): 269–75. doi:10.1016/S0378-1119(96)00861-X. PMID 9168137.
- Saunier S, Calado J, Heilig R, et al. (1998). "A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis". Hum. Mol. Genet. 6 (13): 2317–23. doi:10.1093/hmg/6.13.2317. PMID 9361039.
- de Marco MC, Kremer L, Albar JP, et al. (2001). "BENE, a novel raft-associated protein of the MAL proteolipid family, interacts with caveolin-1 in human endothelial-like ECV304 cells". J. Biol. Chem. 276 (25): 23009–17. doi:10.1074/jbc.M009739200. PMID 11294831.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.