NME1-NME2

NME1-NME2
Dostupne strukture
PDB	Pretraga Human UniProta: PDBe RCSB
Spisak PDB ID kodova
	3BBB, 3BBF, 1NSK, 3BBC, 1NUE
Identifikatori
Aliasi	NME1-NME2
Vanjski ID-jevi	MGI: 3648428 HomoloGene: 39553 GeneCards: NME1-NME2
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	51,171,744 bp
Ontologija gena
Molekularna funkcija	• aktivnost sa transferazom; • vezivanje sa DNK; • nucleotide binding; • protein histidine kinase activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • vezivanje iona metala; • kinase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • nucleoside diphosphate kinase activity; • protein serine/threonine kinase activity; • fatty acid binding; • intermediate filament binding; • vezivanje enzima; • GO:0001105 transcription coactivator activity; • GDP binding; • G-quadruplex DNA binding;
Ćelijska komponenta	• citoplazma; • citosol; • projekcija ćelije; • focal adhesion; • ruffle; • Egzosom; • jedro; • cell periphery; • lamellipodium; • extracellular region; • secretory granule lumen; • ficolin-1-rich granule lumen; • Intermedijarni filament; • mitochondrial membranes; • perinuklearno područje citoplazme;
Biološki proces	• UTP biosynthetic process; • peptidyl-histidine phosphorylation; • nucleobase-containing small molecule interconversion; • CTP biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • Fosforilacija; • positive regulation of epithelial cell proliferation; • positive regulation of keratinocyte differentiation; • negative regulation of apoptotic process; • nucleotide metabolic process; • nucleoside diphosphate phosphorylation; • transcription, DNA-templated; • Ćelijska adhezija; • nucleoside triphosphate biosynthetic process; • integrin-mediated signaling pathway; • GTP biosynthetic process; • regulation of epidermis development; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • neutrophil degranulation; • negative regulation of myeloid leukocyte differentiation; • positive regulation of neuron projection development; • cellular response to oxidative stress; • protein autophosphorylation; • protein complex oligomerization; • response to growth hormone; • cellular response to glucose stimulus; • cellular response to fatty acid; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated;
	Izvori:Amigo / QuickGO
Ortolozi
	654364
	433968
	ENSG00000011052
	n/a
	P22392
	n/a
	NM_001018136
	n/a
NP_001018147; NP_001018148; NP_001018149; NP_001185611; NP_002503;
	NP_001018146
	n/a
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

NM23-LV, znan i kao NME1-NME2, je ljudski gen.^[4]

MRNA NME1-NME2 prirodni je kotranskribirani proizvod susjednih gena NME1 i NME2. Značaj ove kotranskribirane iRNK i funkcija predviđenog proteinskog proizvoda još nisu utvrđeni.

Alternativna prerada transkripta ovog gena rezultira različitim varijantama transkripta koji kodiraju različite izoforme, ali priroda pune dužine svake varijante nije određena.^[4]

Dužina polipeptidnog lanca je 152 aminokiseline, sa molekulskom težinom od 17.298.^[5].

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MANLERTFIA	IKPDGVQRGL	VGEIIKRFEQ	KGFRLVAMKF	LRASEEHLKQ
HYIDLKDRPF	FPGLVKYMNS	GPVVAMVWEG	LNVVKTGRVM	LGETNPADSK
PGTIRGDFCI	QVGRNIIHGS	DSVKSAEKEI	SLWFKPEELV	DYKSCAHDWV
YE

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000011052 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: NME1-NME2 NM23-LV".
^ "UniProt, P22392". Pristupljeno 12. 9. 2017.

Dopunska literatura[uredi | uredi izvor]

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Valentijn LJ, Koster J, Versteeg R (2006). "Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV". Genomics. 87 (4): 483–9. doi:10.1016/j.ygeno.2005.11.004. PMID 16442775.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000011052 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: NME1-NME2 NM23-LV".

[UniProt-5] "UniProt, P22392". Pristupljeno 12. 9. 2017.

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