SLC39A1

SLC39A1
Identifikatori
Aliasi	SLC39A1
Vanjski ID-jevi	OMIM: 604740 MGI: 1353474 HomoloGene: 40906 GeneCards: SLC39A1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	153,968,184 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	90,160,919 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• metal ion transmembrane transporter activity; • inorganic cation transmembrane transporter activity; • zinc ion transmembrane transporter activity; • signaling receptor binding;
Ćelijska komponenta	• integral component of membrane; • ćelijska membrana; • endoplasmic reticulum membrane; • membrana; • Endoplazmatski retikulum;
Biološki proces	• embryonic cranial skeleton morphogenesis; • GO:0070839 metal ion transport; • zinc ion transmembrane transport; • cation transport; • zinc ion transport; • in utero embryonic development; • ion transport; • limb development; • transmembrane transport;
	Izvori:Amigo / QuickGO
Ortolozi
	27173
	30791
	ENSG00000143570
	ENSMUSG00000052310
	Q9NY26
	Q9QZ03
NM_014437; NM_001271957; NM_001271958; NM_001271959; NM_001271960;
	NM_001271961
	NM_013901
NP_001258886; NP_001258887; NP_001258888; NP_001258889; NP_001258890;
	NP_055252
	NP_038929
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Cinkov transporter ZIP1 jest protein koji je kod ljudi kodiran genom SLC39A1 sa hromosoma 1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 324 aminokiseline, a molekulska težina 34.250 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGPWGEPELL	VWRPEAVASE	PPVPVGLEVK	LGALVLLLVL	TLLCSLVPIC
VLRRPGANHE	GSASRQKALS	LVSCFAGGVF	LATCLLDLLP	DYLAAIDEAL
AALHVTLQFP	LQEFILAMGF	FLVLVMEQIT	LAYKEQSGPS	PLEETRALLG
TVNGGPQHWH	DGPGVPQASG	APATPSALRA	CVLVFSLALH	SVFEGLAVGL
QRDRARAMEL	CLALLLHKGI	LAVSLSLRLL	QSHLRAQVVA	GCGILFSCMT
PLGIGLGAAL	AESAGPLHQL	AQSVLEGMAA	GTFLYITFLE	ILPQELASSE
QRILKVILLL	AGFALLTGLL	FIQI

Funkcija[uredi | uredi izvor]

Protein ZIP1 odgovoran je za aktivni transport cinka u ćelije prostate. U mnogim slučajevima karcinoma prostate, SLC39A1 je utišan zbog čega ćelije kanceri prostate imaju nizak sadržaj cinka.^[9]

Također pogledajte[uredi | uredi izvor]

Rastvorni nosač

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143570 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052310 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
^ "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 18. 12. 2021.
^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Dopunska literatura[uredi | uredi izvor]

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Gaither LA, Eide DJ (2001). "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells". J. Biol. Chem. 276 (25): 22258–64. doi:10.1074/jbc.M101772200. PMID 11301334.
Milon B, Dhermy D, Pountney D, et al. (2001). "Differential subcellular localization of hZip1 in adherent and non-adherent cells". FEBS Lett. 507 (3): 241–6. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Franklin RB, Ma J, Zou J, et al. (2003). "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells". J. Inorg. Biochem. 96 (2–3): 435–42. doi:10.1016/S0162-0134(03)00249-6. PMC 4465841. PMID 12888280.
Dufner-Beattie J, Langmade SJ, Wang F, et al. (2004). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Franklin RB, Feng P, Milon B, et al. (2006). "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer. 4: 32. doi:10.1186/1476-4598-4-32. PMC 1243239. PMID 16153295.
Tang Z, Sahu SN, Khadeer MA, et al. (2006). "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone. 38 (2): 181–98. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Huang L, Kirschke CP (2007). "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580. S2CID 21792127.

Vanjski linkovi[uredi | uredi izvor]

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143570 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052310 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10610721-5] Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.

[pmid10681536-6] Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.

[entrez-7] "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".

[UniProt-8] "UniProt, Q9NY26" (jezik: engleski). Pristupljeno 18. 12. 2021.

[pmid16700911-9] Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

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