SLU7

SLU7
Identifikatori
Aliasi	SLU7
Vanjski ID-jevi	OMIM: 605974 MGI: 2385598 HomoloGene: 4690 GeneCards: SLU7
Lokacija gena (čovjek)
Hrom.	Hromosom 5 (čovjek)
Kraj	160,421,711 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	43,338,808 bp
Ontologija gena
Molekularna funkcija	• pre-mRNA 3'-splice site binding; • second spliceosomal transesterification activity; • vezivanje iona metala; • GO:0001948, GO:0016582 vezivanje za proteine; • nucleic acid binding; • vezivanje iona cinka;
Ćelijska komponenta	• citoplazma; • nuclear speck; • catalytic step 2 spliceosome; • membrana; • intracellular membrane-bounded organelle; • small nuclear ribonucleoprotein complex; • spliceosomal complex; • jedro; • nukleoplazma; • citosol;
Biološki proces	• cellular response to heat; • RNA splicing, via transesterification reactions; • mRNA processing; • mRNA 3'-splice site recognition; • Prerada RNK; • intracellular protein transport; • Alternativna prerada RNK; • RNA export from nucleus; • mRNA splicing, via spliceosome; • mRNA export from nucleus; • mRNA 3'-end processing; • termination of RNA polymerase II transcription;
	Izvori:Amigo / QuickGO
Ortolozi
	10569
	193116
	ENSG00000164609
	ENSMUSG00000020409
	O95391
	Q8BHJ9
	NM_006425
	NM_148673; NM_198936
NP_006416; NP_001351446; NP_001351447; NP_001351449; NP_001351450;
	NP_001351451; NP_001351452
	NP_683514; NP_945174
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pre-iRNK-splajsing faktor SLU7 jest protein koji je kod ljudi kodiran genom SLU7 sa hromosoma 5.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 586 aminokiselina, а molekulska težina 68.387 Da.^[8]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MSATVVDAVN	AAPLSGSKEM	SLEEPKKMTR	EDWRKKKELE	EQRKLGNAPA
EVDEEGKDIN	PHIPQYISSV	PWYIDPSKRP	TLKHQRPQPE	KQKQFSSSGE
WYKRGVKENS	IITKYRKGAC	ENCGAMTHKK	KDCFERPRRV	GAKFTGTNIA
PDEHVQPQLM	FDYDGKRDRW	NGYNPEEHMK	IVEEYAKVDL	AKRTLKAQKL
QEELASGKLV	EQANSPKHQW	GEEEPNSQME	KDHNSEDEDE	DKYADDIDMP
GQNFDSKRRI	TVRNLRIRED	IAKYLRNLDP	NSAYYDPKTR	AMRENPYANA
GKNPDEVSYA	GDNFVRYTGD	TISMAQTQLF	AWEAYDKGSE	VHLQADPTKL
ELLYKSFKVK	KEDFKEQQKE	SILEKYGGQE	HLDAPPAELL	LAQTEDYVEY
SRHGTVIKGQ	ERAVACSKYE	EDVKIHNHTH	IWGSYWKEGR	WGYKCCHSFF
KYSYCTGEAG	KEIVNSEECI	INEITGEESV	KKPQTLMELH	QEKLKEEKKK
KKKKKKKHRK	SSSDSDDEEK	KHEKLKKALN	AEEARLLHVK	ETMQIDERKR
PYNSMYETRE	PTEEEMEAYR	MKRQRPDDPM	ASFLGQ

Funkcija[uredi | uredi izvor]

Splajsing pre-iRNK događa se u dva uzastopna transesterifikacijska koraka. Protein kodiran ovim genom je faktor prerade, za koji je utvrđeno da je neophodan tokom drugog katalitskog koraka u procesu prerade pre-iRNK. Povezuje se sa splajsosomom i sadrži motiv cinkovog zgloba, koji se nalazi u drugim faktorima splajsinga i uključen je u interakcije protein-proteini protein-nukleinske kiseline.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chua K, Reed R (maj 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
^ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
^ ^a ^b "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".
^ "UniProt, O95391" (jezik: engleski). Pristupljeno 20. 10. 2021.

Dopunska literatura[uredi | uredi izvor]

Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016. S2CID 4428185.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164609 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020409 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10197984-5] Chua K, Reed R (maj 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.

[pmid15728250-6] Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.

[entrez-7] "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".

[UniProt-8] "UniProt, O95391" (jezik: engleski). Pristupljeno 20. 10. 2021.

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