TECPR1

TECPR1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	4TQ1
Identifikatori
Aliasi	TECPR1
Vanjski ID-jevi	OMIM: 614781 MGI: 1917631 HomoloGene: 9120 GeneCards: TECPR1
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	98,252,232 bp
Lokacija gena (miš)
Hrom.	Hromosom 5 (miš)
Kraj	144,160,433 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • phosphatidylinositol-3-phosphate binding; • lipid binding;
Ćelijska komponenta	• integral component of membrane; • lysosomal membrane; • autophagosome membrane; • Lizozom; • GO:0016023 citoplazmatska vezikula; • membrana; • nukleoplazma; • intracellular membrane-bounded organelle;
Biološki proces	• Autofagija; • GO:0000046 autophagosome maturation;
	Izvori:Amigo / QuickGO
Ortolozi
	25851
	70381
	ENSG00000205356
	ENSMUSG00000066621
	Q7Z6L1
	Q80VP0
	NM_015395
	NM_027410; NM_001356992; NM_001356993
	NP_056210
	NP_081686; NP_001343921; NP_001343922
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Tektonin sa beta-propelerskim ponavljanjem 1 jest protein koji je kod ljudi kodiran genom TECPR1.^[5]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 1.165 aminokiselina, а molekulska težina 129.696 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MPNSVLWAVD	LFGRVYTLST	AGQYWEMCKD	SQLEFKRVSA	TTQCCWGIAC
DNQVYVYVCA	SDVPIRRREE	AYENQRWNPM	GGFCEKLLLS	DRWGWSDVSG
LQHRPLDRVA	LPSPHWEWES	DWYVDENFGG	EPTEKGGWTY	AIDFPATYTK
DKKWNSCVRR	RKWIRYRRYK	SRDIWAKIPS	KDDPKELPDP	FNDLSVGGWE
ITEEPVGRLS	VWAVSLQGKV	WYREDVSHSN	PEGSSWSLLD	TPGEVVQISC
GPHDLLWATL	WEGQALVREG	INRSNPKGSS	WSIVEPPGSE	NGVMHISVGV
SVVWAVTKDW	KVWFRRGVNS	HNPCGTSWIE	MVGEMTMVNV	GMNDQVWGIG
CEDRAVYFRQ	GVTPSELSGK	TWKAIIAARE	CDRSHSGSSS	SLLSAGCFFG
DEVRGSGESA	PSDTDASSEV	ERPGPGQILP	AEPLDDSKNA	TGNSASGLGA
GRTAEDTVED	ACPAEGSREA	RPNTHPGPAP	TPAELPWTNI	DLKEAKKVPS
HSAAGFPETT	SLSSLGLLPL	GLEEPYGVDD	HPLWAWVSGG	GCVVEACAMP
RWFTVQAGLS	SSVHMLSLSI	TPAQTAAWRK	QIFQQLTERT	KRELENFRHY
EQAVEQSVWV	KTGALQWWCD	WKPHKWVDVR	LALEQFTGHD	GVRDSILFIY
YVVHEEKKYI	HIFLNEVVAL	VPVLNETKHS	FALYTPERTR	QRWPVRLAAA
TEQDMNDWLA	LLSLSCCESR	KVQGRPSPQA	IWSITCKGDI	FVSEPSPDLE
AHEHPLPCDQ	MFWRQMGGHL	RMVEANSRGV	VWGIGYDHTA	WVYTGGYGGG
CFQGLASSTS	NIYTQSDVKC	VHIYENQRWN	PVTGYTSRGL	PTDRYMWSDA
SGLQECTKAG	TKPPSLQWAW	VSDWFVDFSV	PGGTDQEGWQ	YASDFPASYH
GSKTMKDFVR	RRCWARKCKL	VTSGPWLEVP	PIALRDVSII	PESPGAEGSG
HSIALWAVSD	KGDVLCRLGV	SELNPAGSSW	LHVGTDQPFA	SISIGACYQV
WAVARDGSAF	YRGSVYPSQP	AGDCWYHIPS	PPRQRLKQVS	AGQTSVYALD
ENGNLWYRQG	ITPSYPQGSS	WEHVSNNVCR	VSVGPLDQVW	VIANKVQGSH
SLSRGTVCHR	TGVQPHEPKG	HGWDYGIGGG	WDHISVRANA	TRAPRSSSQE
QEPSAPPEAH	GPVCC

Funkcija[uredi | uredi izvor]

Ovaj gen kodira faktor vezivanja uključen u autofagiju. Kodirani protein nalazi se na autolizosomima i uključen je u ciljanje proteinskih agregata, oštećenih mitohondrija i bakterijskih patogena za autofagiju.

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205356 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066621 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tectonin beta-propeller repeat containing 1". Pristupljeno 3. 1. 2017.
^ "UniProt, Q7Z6L1" (jezik: engleski). Pristupljeno 29. 9. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205356 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066621 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tectonin beta-propeller repeat containing 1". Pristupljeno 3. 1. 2017.

[UniProt-6] "UniProt, Q7Z6L1" (jezik: engleski). Pristupljeno 29. 9. 2021.

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