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Tonsokuiliki protein popravljanja oštećene DNK je protein koji je kod ljudi kodiran genom TONSL .[1]
Dužina polipeptidnog lanca je 1.378 aminokiselina , а molekulska težina 150.929 Da .[2]
10 20 30 40 50 MSLERELRQL SKAKAKAQRA GQRREEAALC HQLGELLAGH GRYAEALEQH WQELQLRERA DDPLGCAVAH RKIGERLAEM EDYPAALQHQ HQYLELAHSL RNHTELQRAW ATIGRTHLDI YDHCQSRDAL LQAQAAFEKS LAIVDEELEG TLAQGELNEM RTRLYLNLGL TFESLQQTAL CNDYFRKSIF LAEQNHLYED LFRARYNLGT IHWRAGQHSQ AMRCLEGARE CAHTMRKRFM ESECCVVIAQ VLQDLGDFLA AKRALKKAYR LGSQKPVQRA AICQNLQHVL AVVRLQQQLE EAEGRDPQGA MVICEQLGDL FSKAGDFPRA AEAYQKQLRF AELLDRPGAE RAIIHVSLAT TLGDMKDHHG AVRHYEEELR LRSGNVLEEA KTWLNIALSR EEAGDAYELL APCFQKALSC AQQAQRPQLQ RQVLQHLHTV QLRLQPQEAP ETETRLRELS VAEDEDEEEE AEEAAATAES EALEAGEVEL SEGEDDTDGL TPQLEEDEEL QGHLGRRKGS KWNRRNDMGE TLLHRACIEG QLRRVQDLVR QGHPLNPRDY CGWTPLHEAC NYGHLEIVRF LLDHGAAVDD PGGQGCEGIT PLHDALNCGH FEVAELLLER GASVTLRTRK GLSPLETLQQ WVKLYRRDLD LETRQKARAM EMLLQAAASG QDPHSSQAFH TPSSLLFDPE TSPPLSPCPE PPSNSTRLPE ASQAHVRVSP GQAAPAMARP RRSRHGPASS SSSSEGEDSA GPARPSQKRP RCSATAQRVA AWTPGPASNR EAATASTSRA AYQAAIRGVG SAQSRLGPGP PRGHSKALAP QAALIPEEEC LAGDWLELDM PLTRSRRPRP RGTGDNRRPS STSGSDSEES RPRARAKQVR LTCMQSCSAP VNAGPSSLAS EPPGSPSTPR VSEPSGDSSA AGQPLGPAPP PPIRVRVQVQ DHLFLIPVPH SSDTHSVAWL AEQAAQRYYQ TCGLLPRLTL RKEGALLAPQ DLIPDVLQSN DEVLAEVTSW DLPPLTDRYR RACQSLGQGE HQQVLQAVEL QGLGLSFSAC SLALDQAQLT PLLRALKLHT ALRELRLAGN RLGDKCVAEL VAALGTMPSL ALLDLSSNHL GPEGLRQLAM GLPGQATLQS LEELDLSMNP LGDGCGQSLA SLLHACPLLS TLRLQACGFG PSFFLSHQTA LGSAFQDAEH LKTLSLSYNA LGAPALARTL QSLPAGTLLH LELSSVAAGK GDSDLMEPVF RYLAKEGCAL AHLTLSANHL GDKAVRDLCR CLSLCPSLIS LDLSANPEIS CASLEELLST LQKRPQGLSF LGLSGCAVQG PLGLGLWDKI AAQLRELQLC SRRLCAEDRD ALRQLQPSRP GPGECTLDHG SKLFFRRL
Smatra se da je protein kodiran ovim genom negativan regulator NF-kappa-B posredovane transkripcije. Kodirani protein može vezati komplekse NF-kappa-B i zarobiti ih u citoplazmi , sprječavajući ih da uđu u jedro i stupe u interakciju s DNK . Fosforilacija ovog proteina cilja ga na razgradnju putem ubikvitinacije , što oslobađa komplekse NF-kappa-B da uđu u ćelijsko jedro .
Ask K, Jasencakova Z, Menard P, Feng Y, Almouzni G, Groth A (april 2012). "Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply" . The EMBO Journal . 31 (8): 2013–23. doi :10.1038/emboj.2012.55 . PMC 3343338 PMID 22407294 . Norman DA, Barton PJ (januar 2000). "Isolation, sequence, and chromosomal localisation of the human IkappaBR gene (NFKBIL2)" . Annals of Human Genetics . 64 (Pt 1): 15–23. doi :10.1046/j.1469-1809.2000.6410015.x PMID 11246458 . S2CID 83963944 . Duro E, Lundin C, Ask K, Sanchez-Pulido L, MacArtney TJ, Toth R, Ponting CP, Groth A, Helleday T, Rouse J (novembar 2010). "Identification of the MMS22L-TONSL complex that promotes homologous recombination" . Molecular Cell . 40 (4): 632–44. doi :10.1016/j.molcel.2010.10.023 PMID 21055984 . O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW (novembar 2010). "A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability" . Molecular Cell . 40 (4): 645–57. doi :10.1016/j.molcel.2010.10.022 . PMC 3006237 PMID 21055985 . O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, Mendez M, Mullin M, Sun T, Habermann B, Datti A, Bristow RG, Gingras AC, Tyers MD, Brown GW, Durocher D (novembar 2010). "The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination" . Molecular Cell . 40 (4): 619–31. doi :10.1016/j.molcel.2010.10.024 . PMC 3031522 PMID 21055983 . Chapman SJ, Khor CC, Vannberg FO, Rautanen A, Walley A, Segal S, Moore CE, Davies RJ, Day NP, Peshu N, Crook DW, Berkley JA, Williams TN, Scott JA, Hill AV (2010). "Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study" . Critical Care . 14 (6): R227. doi :10.1186/cc9377 . PMC 3220025 PMID 21171993 . Ray P, Zhang DH, Elias JA, Ray A (maj 1995). "Cloning of a differentially expressed I kappa B-related protein" . The Journal of Biological Chemistry . 270 (18): 10680–5. doi :10.1074/jbc.270.18.10680 PMID 7738005 . Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PG, Hofmann K, Pasero P, Gerlich DW, Peter M (decembar 2010). "RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells" . The EMBO Journal . 29 (24): 4210–22. doi :10.1038/emboj.2010.304 . PMC 3018799 PMID 21113133 . 
