CYP4B1

CYP4B1
Identifikatori
Aliasi	CYP4B1
Vanjski ID-jevi	OMIM: 124075 MGI: 103225 HomoloGene: 128045 GeneCards: CYP4B1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	46,819,413 bp
Lokacija gena (miš)
Hrom.	Hromosom 4 (miš)
Kraj	115,504,920 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• iron ion binding; • oxygen binding; • vezivanje iona metala; • fluorene oxygenase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • aromatase activity; • toxic substance binding; • monooxygenase activity;
Ćelijska komponenta	• organelle membrane; • endoplasmic reticulum membrane; • membrana; • intracellular membrane-bounded organelle; • Endoplazmatski retikulum;
Biološki proces	• biphenyl metabolic process; • cellular aromatic compound metabolic process;
	Izvori:Amigo / QuickGO
Ortolozi
	1580
	13120
	ENSG00000142973
	ENSMUSG00000028713
	P13584
	Q64462
	NM_000779; NM_001099772; NM_001319161; NM_001319162; NM_001319163
	NM_007823
	NP_000770; NP_001093242; NP_001306090; NP_001306091; NP_001306092
	NP_031849
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Citohrom P450 4B1 jest protein koji je kod ljudi kodiran genom CYP4B1 sa hromosoma 1.^[5]

Amiokiselininska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 511 aminokiselina, a molekulska težina 58.991 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MVPSFLSLSF	SSLGLWASGL	ILVLGFLKLI	HLLLRRQTLA	KAMDKFPGPP
THWLFGHALE	IQETGSLDKV	VSWAHQFPYA	HPLWFGQFIG	FLNIYEPDYA
KAVYSRGDPK	APDVYDFFLQ	WIGRGLLVLE	GPKWLQHRKL	LTPGFHYDVL
KPYVAVFTES	TRIMLDKWEE	KAREGKSFDI	FCDVGHMALN	TLMKCTFGRG
DTGLGHRDSS	YYLAVSDLTL	LMQQRLVSFQ	YHNDFIYWLT	PHGRRFLRAC
QVAHDHTDQV	IRERKAALQD	EKVRKKIQNR	RHLDFLDILL	GARDEDDIKL
SDADLRAEVD	TFMFEGHDTT	TSGISWFLYC	MALYPEHQHR	CREEVREILG
DQDFFQWDDL	GKMTYLTMCI	KESFRLYPPV	PQVYRQLSKP	VTFVDGRSLP
AGSLISMHIY	ALHRNSAVWP	DPEVFDSLRF	STENASKRHP	FAFMPFSAGP
RNCIGQQFAM	SEMKVVTAMC	LLRFEFSLDP	SRLPIKMPQL	VLRSKNGFHL
HLKPLGPGSG	K

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana natporodice enzima citohroma P450. Proteini citokroma P450 su monooksigenaze koje katalizirju mnoge reakcije uključene u metabolizam lijekova i sintezu holesterola, steroida i ostalih lipida. Ovaj protein se lokalizira u endoplazmatski retikulum. Kod glodara se pokazalo da homologni protein metabolizira određene karcinogene; međutim, specifična funkcija ljudskog proteina nije utvrđena.^[5]

Mišji mutantni aleli za Cyp4b1
Markerski simbol za mišji gen. Ovaj simbol je dodijeljen genomskom lokusu prema MGI	Cyp4b1
Mutantni klonovi mišjih embrionskih matičnih ćelija. Ovo su poznate ciljane mutacije za ovaj gen kod miša.	CYP4B1^{tm1a(KOMP)Wtsi}
Primjer strukture ciljanog uslovnog mutantnog alela za ovaj gen
Molekulska struktura regije Cyp4b1 sa insertriranom mutiranom sekvencom
Ove mutantne ES ćelije mogu se proučavati direktno ili koristiti za generiranje miševa sa nokautiranim ovim genom. Proučavanje ovih miševa može rasvijetliti funkciju Cyp4b1: Vidi: Nokaut-miš

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142973 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028713 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1".
^ "UniProt, P13584" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura[uredi | uredi izvor]

Windmill KF, McKinnon RA, Zhu X, et al. (1997). "The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies". Mutat. Res. 376 (1–2): 153–60. doi:10.1016/S0027-5107(97)00038-9. PMID 9202751.
Hakkola J, Pelkonen O, Pasanen M, Raunio H (1998). "Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: role in intrauterine toxicity". Crit. Rev. Toxicol. 28 (1): 35–72. doi:10.1080/10408449891344173. PMID 9493761.
Yokotani N, Sogawa K, Matsubara S, et al. (1990). "cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA library of human placenta. Gene structure and expression". Eur. J. Biochem. 187 (1): 23–9. doi:10.1111/j.1432-1033.1990.tb15273.x. PMID 2298205.
Nhamburo PT, Gonzalez FJ, McBride OW, et al. (1990). "Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping". Biochemistry. 28 (20): 8060–6. doi:10.1021/bi00446a014. PMID 2574990.
McKinnon RA, Burgess WM, Gonzalez FJ, et al. (1995). "Species-specific expression of CYP4B1 in rabbit and human gastrointestinal tissues". Pharmacogenetics. 4 (5): 260–70. doi:10.1097/00008571-199410000-00004. PMID 7894498.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Czerwinski M, McLemore TL, Gelboin HV, Gonzalez FJ (1994). "Quantification of CYP2B7, CYP4B1, and CYPOR messenger RNAs in normal human lung and lung tumors". Cancer Res. 54 (4): 1085–91. PMID 8313365.
Hakkola J, Raunio H, Purkunen R, et al. (1996). "Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy". Biochem. Pharmacol. 52 (2): 379–83. doi:10.1016/0006-2952(96)00216-X. PMID 8694864.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hukkanen J, Hakkola J, Anttila S, et al. (1997). "Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes". Mol. Carcinog. 20 (2): 224–30. doi:10.1002/(SICI)1098-2744(199710)20:2<224::AID-MC9>3.0.CO;2-M. PMID 9364212.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hukkanen J, Mäntylä M, Kangas L, et al. (1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium". Pharmacol. Toxicol. 82 (2): 93–7. doi:10.1111/j.1600-0773.1998.tb01404.x. PMID 9498238.
Thum T, Borlak J (2000). "Gene expression in distinct regions of the heart". Lancet. 355 (9208): 979–83. doi:10.1016/S0140-6736(00)99016-0. PMID 10768437. S2CID 23176414.
Imaoka S, Yoneda Y, Sugimoto T, et al. (2000). "CYP4B1 is a possible risk factor for bladder cancer in humans". Biochem. Biophys. Res. Commun. 277 (3): 776–80. doi:10.1006/bbrc.2000.3740. PMID 11062028.
Henne KR, Kunze KL, Zheng YM, et al. (2001). "Covalent linkage of prosthetic heme to CYP4 family P450 enzymes". Biochemistry. 40 (43): 12925–31. doi:10.1021/bi011171z. PMID 11669629.
Finnström N, Bjelfman C, Söderström TG, et al. (2002). "Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR". Eur. J. Clin. Invest. 31 (10): 880–6. doi:10.1046/j.1365-2362.2001.00893.x. PMID 11737226. S2CID 22814284.
Iscan M, Klaavuniemi T, Coban T, et al. (2002). "The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue". Breast Cancer Res. Treat. 70 (1): 47–54. doi:10.1023/A:1012526406741. PMID 11767004. S2CID 25813919.
Lo-Guidice JM, Allorge D, Cauffiez C, et al. (2003). "Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant". Pharmacogenetics. 12 (5): 367–74. doi:10.1097/00008571-200207000-00004. PMID 12142726.

Vanjski linkovi[uredi | uredi izvor]

Šablon:Citohrom P450

Lokacija ljudskog genoma CYP4B1 i stranica sa detaljima o genu CYP4B1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142973 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028713 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1".

[UniProt-6] "UniProt, P13584" (jezik: engleski). Pristupljeno 23. 11. 2021.

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