BCAS1

BCAS1
Identifikatori
Aliasi	BCAS1
Vanjski ID-jevi	OMIM: 602968 MGI: 1924210 HomoloGene: 2714 GeneCards: BCAS1
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	54,070,594 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	170,269,765 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	8537
	76960
	ENSG00000064787
	ENSMUSG00000013523
	O75363
	Q80YN3
NM_003657; NM_001316361; NM_001323347; NM_001366295; NM_001366296;
	NM_001366297; NM_001366298
	NM_001164369; NM_029815
NP_001303290; NP_001310276; NP_003648; NP_001353224; NP_001353225;
	NP_001353226; NP_001353227
	NP_001157841; NP_084091
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Aplificirana sekvenca 1 karcinoma dojče je protein koji je kod ljudi kodiran genom BCAS1.^[5]^[6]

Sekvenca 1 karcinomom dojke (BCAS1) izolirana je iz regije na poziciji 20q13 koji je umnožen u raznim tumorskim tipovima i povezan sa agresivnijim fenotipovima tumora. Među identificiranim genima iz ove regije, utvrđeno je da je BCAS1 visoko eksprimiran u triamlificirane ćelijske linije raka dojke i u jednom tumoru dojke bez amlifikacije na 20q13,2. Međutim, gen BCAS1 nije u zajedničkom području maksimalne amplifikacije i njegova ekspresija nije otkrivena u ćelijskoj liniji raka dojke MCF7, u kojoj je ova regija jako umnožena. Iako nije dosljedno izražen, BCAS1 je kandidatski onkogen. Predviđa se da kodira protein od 584 aminokiselina, bez značajne homologije sa ostalim proteinima.^[6]

Reference

1 2 3 GRCh38: Ensembl release 89: ENSG00000064787 - Ensembl, maj 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013523 - Ensembl, maj 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.
1 2 "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1".

Dopunska literatura

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Tanner MM, Tirkkonen M, Kallioniemi A, et al. (1996). "Independent amplification and frequent co-amplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer". Cancer Res. 56 (15): 3441–5. PMID 8758909.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Correa RG, de Carvalho AF, Pinheiro NA, et al. (2000). "NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors". Genomics. 65 (3): 299–302. doi:10.1006/geno.2000.6172. PMID 10857754.
Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Beardsley DI, Kowbel D, Lataxes TA, et al. (2003). "Characterization of the novel amplified in breast cancer-1 (NABC1) gene product". Exp. Cell Res. 290 (2): 402–13. doi:10.1016/S0014-4827(03)00353-7. PMID 14567997.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000064787 - Ensembl, maj 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013523 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9671742-5] Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW (Aug 1998). "Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma". Proc Natl Acad Sci U S A. 95 (15): 8703–8. doi:10.1073/pnas.95.15.8703. PMC 21140. PMID 9671742.

[entrez-6] 1 2 "Entrez Gene: BCAS1 breast carcinoma amplified sequence 1".

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