S Wikipedije, slobodne enciklopedije
U molekulskoj biologiji, gen 5 kritične nekodirajući regije DiGeorgeovog sindroma, poznat i kao DGCR5, je dugolančana nekodirajuća RNK. Kod ljudi se nalazi na hromosomu, regija 22q11, na ADU prelomnoj tački povezanoj sa DiGeorgeovim sindromom.[3] Njegova ekspresija regulirana je transkripcijskim faktorom REST (RE1-Faktor utišavanja transkripcije).[4]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000273032 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sutherland HF, Wadey R, McKie JM, Taylor C, Atif U, Johnstone KA, Halford S, Kim UJ, Goodship J, Baldini A, Scambler PJ (Jul 1996). "Identification of a novel transcript disrupted by a balanced translocation associated with DiGeorge syndrome". American Journal of Human Genetics. 59 (1): 23–31. PMC 1915101. PMID 8659529.
- ^ Johnson R, Teh CH, Jia H, Vanisri RR, Pandey T, Lu ZH, Buckley NJ, Stanton LW, Lipovich L (Jan 2009). "Regulation of neural macroRNAs by the transcriptional repressor REST". RNA. 15 (1): 85–96. doi:10.1261/rna.1127009. PMC 2612765. PMID 19050060.
