LY6G6E

Lokus G6E kompleksa limfocitnog antigena 6 (pseudogen) jest protein koji je kod ljudi kodiran genom LY6G6E.^[2]

Funkcija

LY6G6E pripada klasteru gena leukocitnog antigena-6 (LY6) koji se nalazi u glavnom kompleksu histokompatibilnosti (MHC) klase III, na hromosomu 6. Članovi LY6 natporodice obično sadrže 70 do 80 aminokiselina, uključujući osam do 10 cisteina. |Većina proteina LY6 vezana je za ćelijsku površinu pomoću glikozilfosfatidilinozitola (GPI) sidra koje je direktno uključeno u transdukciju signala.^[3]

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Lymphocyte antigen 6 complex, locus G6E pseudogene)".
^ Mallya M, Campbell RD, Aguado B (July 2002). "Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms". Genomics. 80 (1): 113–23. doi:10.1006/geno.2002.6794. PMID 12079290.

Mallya M, Campbell RD, Aguado B (October 2006). "Characterization of the five novel Ly-6 superfamily members encoded in the MHC, and detection of cells expressing their potential ligands". Protein Science. 15 (10): 2244–56. doi:10.1110/ps.062242606. PMC 2242401. PMID 17008713.
Ribas G, Neville M, Wixon JL, Cheng J, Campbell RD (July 1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region". Journal of Immunology. 163 (1): 278–87. PMID 10384126.
Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG (January 2009). "Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci". Arthritis and Rheumatism. 60 (1): 53–62. doi:10.1002/art.24138. PMID 19116923.
"Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium". Nature. 401 (6756): 921–3. October 1999. doi:10.1038/44853. PMID 10553908. S2CID 186243515.