CCT3

CCT3
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1GML, 1GN1
Identifikatori
Aliasi	CCT3
Vanjski ID-jevi	OMIM: 600114 MGI: 104708 HomoloGene: 4373 GeneCards: CCT3
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	156,367,873 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	88,229,074 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • protein folding chaperone activity; • GO:0001948, GO:0016582 vezivanje za proteine; • ATP binding; • unfolded protein binding; • vezivanje sa RNK;
Ćelijska komponenta	• cell body; • myelin sheath; • ćelijska membrana; • zona pellucida receptor complex; • TRiC; • Mikrotubula; • citoskelet; • Egzosom; • citoplazma; • citosol;
Biološki proces	• positive regulation of protein localization to Cajal body; • pore complex assembly; • protein stabilization; • positive regulation of telomere maintenance via telomerase; • toxin transport; • Savijanje proteina; • positive regulation of telomerase RNA localization to Cajal body; • binding of sperm to zona pellucida; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	7203
	12462
	ENSG00000163468
	ENSMUSG00000001416
	P49368; Q5SZW8
	P80318
	NM_001008800; NM_001008883; NM_005998
	NM_009836
	NP_001008800; NP_005989
	NP_033966
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica proteina 1 T-kompleksa gama je protein koji je kod ljudi kodiran iz gena CCT3.^[5]^[6]

Funkcija[uredi | uredi izvor]

Ovaj gen kodira molekulski šaperon koji je član kompleksa TRiC. Kompleks sastoji se od dva identična posložena prstena, od kojih svaki sadrži po osam različitih proteina. Nerazvijeni polipeptidi ulaze u središnju šupljinu kompleksa i savijaju se na način ovisan o ATP-u. Savija različite proteine, uključujući aktin i tubulin. Karakterizirane su alternativne transkripcijske varijante spajanja, koje kodiraju različite izoforme.^[6]

Interakcije[uredi | uredi izvor]

Pokazalo se da CCT3 stupa u interakcije sa PPP4C.^[7]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163468 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001416 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.
^ ^a ^b "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".
^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Dopunska literatura[uredi | uredi izvor]

Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
Sévigny G, Joly EC, Bibor-Hardy V, Lemieux N (Aug 1994). "Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization". Genomics. 22 (3): 634–6. doi:10.1006/geno.1994.1438. PMID 8001976.
Walkley NA, Demaine AG, Malik AN (Jan 1996). "Cloning, structure and mRNA expression of human Cctg, which encodes the chaperonin subunit CCT gamma". The Biochemical Journal. 313 (Pt 2): 381–9. doi:10.1042/bj3130381. PMC 1216920. PMID 8573069.
Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J (Dec 1999). "Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC". Molecular Cell. 4 (6): 1051–61. doi:10.1016/S1097-2765(00)80233-6. PMID 10635329.
Wong N, Chan A, Lee SW, Lam E, To KF, Lai PB, Li XN, Liew CT, Johnson PJ (Mar 2003). "Positional mapping for amplified DNA sequences on 1q21-q22 in hepatocellular carcinoma indicates candidate genes over-expression". Journal of Hepatology. 38 (3): 298–306. doi:10.1016/S0168-8278(02)00412-9. PMID 12586295.
Yuryev A, Wennogle LP (Feb 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (Oct 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Experimental Cell Research. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CCT3 i stranica sa detaljima o genu CCT3 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163468 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001416 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8110840-5] Joly EC, Sévigny G, Todorov IT, Bibor-Hardy V (Mar 1994). "cDNA encoding a novel TCP1-related protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1217 (2): 224–6. doi:10.1016/0167-4781(94)90041-8. PMID 8110840.

[entrez-6] "Entrez Gene: CCT3 chaperonin containing TCP1, subunit 3 (gamma)".

[pmid18715871-7] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid16085932-8] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

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