CCT6B

CCT6B
Identifikatori
Aliasi	CCT6B
Vanjski ID-jevi	OMIM: 610730 MGI: 1329013 HomoloGene: 55978 GeneCards: CCT6B
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	34,981,078 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	82,655,147 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• nucleotide binding; • ATP binding; • protein folding chaperone activity; • unfolded protein binding;
Ćelijska komponenta	• citoplazma; • citosol; • TRiC;
Biološki proces	• toxin transport; • Savijanje proteina; • chaperone-mediated protein complex assembly; • Spermatogeneza; • protein transport; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	10693
	12467
	ENSG00000132141
	ENSMUSG00000020698
	Q92526
	Q61390
	NM_001193529; NM_001193530; NM_006584
	NM_001291242; NM_009839
	NP_001180458; NP_001180459; NP_006575
	NP_001278171; NP_033969
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica proteina 1 T-kompleksa zeta-2 je protein koji je kod ljudi kodiran genom CCT6B.^[5]^[6]^[7]

Ovaj gen kodira molekulski šaperon koji je član kompleksa TRiC. Ovaj se kompleks sastoji od dva identična naslagana prstena, od kojih svaki sadrži osam različitih proteina. Nerazvijeni polipeptidi ulaze u središnju šupljinu kompleksa i savijaju se na način ovisan o ATP-u. Kompleks savija različite proteine, uključujući aktin i tubulin. Primijećene su alternativne varijante transkripcijskog spajanja ovog gena, ali nisu temeljito okarakterizirane.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132141 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020698 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.
^ Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858.
^ ^a ^b "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

Dopunska literatura[uredi | uredi izvor]

Stirling PC, Cuéllar J, Alfaro GA, et al. (2006). "PhLP3 modulates CCT-mediated actin and tubulin folding via ternary complexes with substrates". J. Biol. Chem. 281 (11): 7012–21. doi:10.1074/jbc.M513235200. PMID 16415341.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

Vanjski linkovi[uredi | uredi izvor]

https://Human^{[mrtav link]} hg38 CCT6B UCSC Genome Browser v410
https://Human^{[mrtav link]} Gene CCT6B (ENST00000314144.10) Description and Page Index (ucsc.edu)

Commons logo

Commons ima datoteke na temu: CCT6B

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132141 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020698 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812458-5] Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.

[pmid9013858-6] Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858.

[entrez-7] "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".

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