ATRAID
Apoptozno vezani protein 3 jest protein koji je kod ljudi kodiran genom ATRAID sa hromosoma 2.[5][6][7]
Amiokiselininska sekvenca[uredi | uredi izvor]
Dužina polipeptidnog lanca je 229 aminokiselina, a molkekulska iežina 24.747 Da.[8]
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MAPHDPGSLT | TLVPWAAALL | LALGVERALA | LPEICTQCPG | SVQNLSKVAF | ||||
| YCKTTRELML | HARCCLNQKG | TILGLDLQNC | SLEDPGPNFH | QAHTTVIIDL | ||||
| QANPLKGDLA | NTFRGFTQLQ | TLILPQHVNC | PGGINAWNTI | TSYIDNQICQ | ||||
| GQKNLCNNTG | DPEMCPENGS | CVPDGPGLLQ | CVCADGFHGY | KCMRQGSFSL | ||||
| LMFFGILGAT | TLSVSILLWA | TQRRKAKTS |
Funkcija[uredi | uredi izvor]
Smatra se da je ovaj gen uključen u apoptozu, a također može biti uključen u hematopoetski razvoj i diferencijaciju. Za ovaj gen pronađene su dvije alternativno prerađene varijante transkripta koje kodiraju različite izoforme.[7]
Reference[uredi | uredi izvor]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138085 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013622 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- ^ Zhu F, Yan W, Zhao ZL, Chai YB, Lu F, Wang Q, Peng WD, Yang AG, Wang CJ (Nov 2000). "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes". BioTechniques. 29 (2): 310–3. doi:10.2144/00292st06. PMID 10948432.
- ^ a b "Entrez Gene: C2orf28 chromosome 2 open reading frame 28".
- ^ "UniProt, Q6UW56" (jezik: engleski). Pristupljeno 11. 11. 2021.
Dopunska literatura[uredi | uredi izvor]
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Yang G, Yu F, Fu H, et al. (2007). "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB". Mol. Cell. Biochem. 302 (1–2): 187–94. doi:10.1007/s11010-007-9440-7. PMID 17387583. S2CID 1525070.
- Yu F, Yang G, Zhao Z, et al. (2007). "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1". Biochem. Biophys. Res. Commun. 358 (4): 1041–6. doi:10.1016/j.bbrc.2007.05.049. PMID 17524364.
Vanjski linkovi[uredi | uredi izvor]
- Lokacija ljudskog genoma ATRAID i stranica sa detaljima o genu ATRAID u UCSC Genome Browseru.