CCT7

CCT7
Identifikatori
Aliasi	CCT7
Vanjski ID-jevi	OMIM: 605140 MGI: 107184 HomoloGene: 4694 GeneCards: CCT7
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	73,253,021 bp
Lokacija gena (miš)
Hrom.	Hromosom 6 (miš)
Kraj	85,445,457 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleotide binding; • vezivanje identičnih proteina; • ATP binding; • protein folding chaperone activity; • unfolded protein binding;
Ćelijska komponenta	• citoplazma; • mitohondrija; • citosol; • cell body; • zona pellucida receptor complex; • Mikrotubula; • Egzosom; • TRiC;
Biološki proces	• positive regulation of protein localization to Cajal body; • positive regulation of telomerase RNA localization to Cajal body; • positive regulation of telomere maintenance via telomerase; • toxin transport; • positive regulation of establishment of protein localization to telomere; • Savijanje proteina; • binding of sperm to zona pellucida; • protein stabilization; • 'de novo' protein folding; • chaperone-mediated protein folding;
	Izvori:Amigo / QuickGO
Ortolozi
	10574
	12468
	ENSG00000135624
	ENSMUSG00000030007
	Q99832
	P80313
	NM_001009570; NM_001166284; NM_001166285; NM_006429
	NM_007638
	NP_001009570; NP_001159756; NP_001159757; NP_006420
	NP_031664
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica proteina T-kompleksa eta je protein koji je kod ljudi kodiran genom CCT7 .^[5]^[6]

Funkcija[uredi | uredi izvor]

Ovaj gen kodira molekulski šaperon, koji je član kompleksa TRiC. Ovaj kompleks sastoji se od dva identična složena prstena, od kojih svaki sadrži osam različitih proteina. Nerazvijeni polipeptidi ulaze u središnju šupljinu kompleksa i savijaju se na način ovisan o ATP-u. Kompleks savija različite proteine, uključujući aktin i tubulin. Za ovaj gen pronađene su alternativne transkripcijske spojne varijante koje kodiraju različite izoforme, ali do danas su okarakterizirane samo dvije od njih.^[6]

Interakcije[uredi | uredi izvor]

Dokazano je da CCT7 međusobno reagiraju sa PPP4C.^[7]^[8]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135624 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030007 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.
^ ^a ^b "Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)".
^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

Dopunska literatura[uredi | uredi izvor]

Kubota H, Hynes G, Carne A, Ashworth A, Willison K (Feb 1994). "Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin". Current Biology. 4 (2): 89–99. doi:10.1016/S0960-9822(94)00024-2. PMID 7953530.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hynes G, Celis JE, Lewis VA, Carne A, U S, Lauridsen JB, Willison KR (Nov 1996). "Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits". Electrophoresis. 17 (11): 1720–7. doi:10.1002/elps.1150171109. PMID 8982604.CS1 održavanje: datum i godina (link)
Liou AK, Willison KR (Jul 1997). "Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes". The EMBO Journal. 16 (14): 4311–6. doi:10.1093/emboj/16.14.4311. PMC 1170057. PMID 9250675.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yokota S, Yanagi H, Yura T, Kubota H (Sep 2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". European Journal of Biochemistry / FEBS. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". The Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.CS1 održavanje: datum i godina (link)
Hanafy KA, Martin E, Murad F (Nov 2004). "CCTeta, a novel soluble guanylyl cyclase-interacting protein". The Journal of Biological Chemistry. 279 (45): 46946–53. doi:10.1074/jbc.M404134200. PMID 15347653.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135624 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030007 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819444-5] Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI (Dec 1998). "Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT". Molecular and Cellular Biology. 18 (12): 7584–9. doi:10.1128/mcb.18.12.7584. PMC 109339. PMID 9819444.

[entrez-6] "Entrez Gene: CCT7 chaperonin containing TCP1, subunit 7 (eta)".

[pmid18715871-7] Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid16085932-8] Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

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