Natriuretski prekursorni peptid C

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Naturiuretski prekursorni peptid C
Struktura ljudsdkog natriuretskog peptida C-tipa
Raspon ekspresije gena NPPC
Identifikatori
SimbolNPPC
OMIM600296
Orthologs7867
PDBPDBe RCSB; 1JDP (RCSB; 1JDP RCSB PDB RCSB; 1JDP PDBe RCSB; 1JDP PDBj)
UniProtP23582
Ideogram human chromosome 2.svg
Kod čovjeka, genski lokus NPPC je na dugom (q) kraku hromosoma 2; pozicija: 2q37.1

Naturiuretski prekursorni peptid C ili prekursorni natriuretski peptid C, poznat i kao NPPC, je protein koji je kod ljudi kodiran genom NPPC.[1][2][3]Prekursorski NPPC protein se cijepa na 22 aminokiselinski peptid natriuretski peptid tipa C (CNP).

Funkcija[uredi | uredi izvor]

Natriuretski peptidi čine porodicu od tri strukturno srodne molekule: pretkomorski (ANP), komorski (BNP) i C-tip natriuretskog peptida (CNP), kodiranih genom koga simbolizira skraćenica NPPC. Ovi peptidi imaju snažne natriuretske, diuretske i vazodilatacijske aktivnosti i uključeni su u homeostazu tjelesne tečnosti i kontrolu krvnog pritiska. Za razliku od ANP i BNP, CNP nema direktnu natriuretsku aktivnost. To je zato što je CNP selektivni agonist za natriuretski receptor B-tipa (NPRB), dok su ANP i BNP selektivni za natriuretski receptor A-tipa (NPRA).[4] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokines.[5]

Reference[uredi | uredi izvor]

  1. ^ "Entrez Gene: NPPC natriuretic peptide precursor C".
  2. ^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  3. ^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  4. ^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.
  5. ^ Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

Dopunska literatura[uredi | uredi izvor]

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  • Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  • Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  • Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC (September 1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. doi:10.1161/01.cir.88.3.1004. PMID 8353861.
  • Igaki T, Itoh H, Suga S, Komatsu Y, Ogawa Y, Doi K, Yoshimasa T, Nakao K (July 1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. doi:10.2337/diab.45.3.s62. PMID 8674895.
  • Igaki T, Itoh H, Suga S, Hama N, Ogawa Y, Komatsu Y, Mukoyama M, Sugawara A, Yoshimasa T, Tanaka I, Nakao K (June 1996). "C-type natriuretic peptide in chronic renal failure and its action in humans". Kidney International Supplements. 55: S144–7. PMID 8743538.
  • Vollmar AM, Paumgartner G, Gerbes AL (January 1997). "Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver". Gut. 40 (1): 145–50. doi:10.1136/gut.40.1.145. PMC 1027025. PMID 9155593.
  • Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y (June 1997). "Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11". Biochemical and Molecular Medicine. 61 (1): 47–51. doi:10.1006/bmme.1997.2584. PMID 9232196.
  • Martick MM, Garcia KC (August 2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone". Science. 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490.
  • Cataliotti A, Giordano M, De Pascale E, Giordano G, Castellino P, Jougasaki M, Costello LC, Boerrigter G, Tsuruda T, Belluardo P, Lee SC, Huntley B, Sandberg S, Malatino LS, Burnett JC (September 2002). "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". American Journal of Physiology. Renal Physiology. 283 (3): F464–72. doi:10.1152/ajprenal.00372.2001. PMID 12167597.
  • Evans JJ, Youssef AH, Yandle TG, Lewis LK, Nicholls MG (October 2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells". The Journal of Endocrinology. 175 (1): 225–32. doi:10.1677/joe.0.1750225. PMID 12379507.
  • Ono K, Mannami T, Baba S, Tomoike H, Suga S, Iwai N (September 2002). "A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension". Hypertension Research. 25 (5): 727–30. doi:10.1291/hypres.25.727. PMID 12452325.
  • Hirsch JR, Skutta N, Schlatter E (August 2003). "Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B". American Journal of Physiology. Renal Physiology. 285 (2): F370–4. doi:10.1152/ajprenal.00049.2003. PMID 12709393.
  • Wu C, Wu F, Pan J, Morser J, Wu Q (July 2003). "Furin-mediated processing of Pro-C-type natriuretic peptide". The Journal of Biological Chemistry. 278 (28): 25847–52. doi:10.1074/jbc.M301223200. PMID 12736257.

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