Natriuretski prekursorni peptid C

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Natriuretski prekursorni peptid C
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

1JDP

Identifikatori
AliasiNPPC
Vanjski ID-jeviOMIM: 600296 MGI: 97369 HomoloGene: 7867 GeneCards: NPPC
Lokacija gena (čovjek)
Hromosom 2 (čovjek)
Hrom.Hromosom 2 (čovjek)[1]
Hromosom 2 (čovjek)
Genomska lokacija za Natriuretski prekursorni peptid C
Genomska lokacija za Natriuretski prekursorni peptid C
Bend2q37.1Početak231,921,809 bp[1]
Kraj231,926,396 bp[1]
Lokacija gena (miš)
Hromosom 1 (miš)
Hrom.Hromosom 1 (miš)[2]
Hromosom 1 (miš)
Genomska lokacija za Natriuretski prekursorni peptid C
Genomska lokacija za Natriuretski prekursorni peptid C
Bend1 C5|1 43.98 cMPočetak86,666,291 bp[2]
Kraj86,670,571 bp[2]
Obrazac RNK ekspresije
PBB GE NPPC 221348 at fs.png
Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija protein homodimerization activity
hormone activity
peptide hormone receptor binding
signaling receptor binding
hormone receptor binding
Ćelijska komponenta secretory granule
extracellular region
Vanćelijsko
protein-containing complex
Biološki proces animal organ development
negative regulation of meiotic cell cycle
regulation of cardiac conduction
growth plate cartilage chondrocyte proliferation
response to hypoxia
ossification
regulation of multicellular organism growth
negative regulation of oocyte maturation
growth plate cartilage chondrocyte differentiation
post-embryonic development
receptor guanylyl cyclase signaling pathway
regulation of smooth muscle cell proliferation
cGMP biosynthetic process
positive regulation of osteoblast differentiation
negative regulation of DNA metabolic process
response to ethanol
response to drug
negative regulation of cell population proliferation
Savijanje proteina
regulation of signaling receptor activity
reproductive process
cGMP-mediated signaling
positive regulation of cGMP-mediated signaling
negative regulation of collagen biosynthetic process
negative regulation of DNA biosynthetic process
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_024409

NM_010933

RefSeq (bjelančevina)

NP_077720

NP_035063

Lokacija (UCSC)Chr 2: 231.92 – 231.93 MbChr 1: 86.67 – 86.67 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Naturiuretski prekursorni peptid C ili prekursorni natriuretski peptid C, poznat i kao NPPC, je protein koji je kod ljudi kodiran genom NPPC.[5][6][7] Prekursorski NPPC protein se cijepa na 22 aminokiselinski peptid natriuretski peptid tipa C (CNP).

Funkcija[uredi | uredi izvor]

Natriuretski peptidi čine porodicu od tri strukturno srodne molekule: pretkomorski (ANP), komorski (BNP) i C-tip natriuretskog peptida (CNP), kodiranih genom koga simbolizira skraćenica NPPC. Ovi peptidi imaju snažne natriuretske, diuretske i vazodilatacijske aktivnosti i uključeni su u homeostazu tjelesne tečnosti i kontrolu krvnog pritiska. Za razliku od ANP i BNP, CNP nema direktnu natriuretsku aktivnost. To je zato što je CNP selektivni agonist za natriuretski receptor B-tipa (NPRB), dok su ANP i BNP selektivni za natriuretski receptor A-tipa (NPRA).[8] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokines.[9]

Reference[uredi | uredi izvor]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NPPC natriuretic peptide precursor C".
  6. ^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (maj 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
  7. ^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (novembar 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  8. ^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.
  9. ^ Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

Dopunska literatura[uredi | uredi izvor]

Također pogledajte[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]