Natriuretski prekursorni peptid C

Natriuretski prekursorni peptid C
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1JDP
Identifikatori
Aliasi	NPPC
Vanjski ID-jevi	OMIM: 600296 MGI: 97369 HomoloGene: 7867 GeneCards: NPPC
Lokacija gena (čovjek)
Hrom.	Hromosom 2 (čovjek)
Kraj	231,926,396 bp
Lokacija gena (miš)
Hrom.	Hromosom 1 (miš)
Kraj	86,598,293 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• protein homodimerization activity; • hormone activity; • peptide hormone receptor binding; • signaling receptor binding; • hormone receptor binding;
Ćelijska komponenta	• secretory granule; • extracellular region; • Vanćelijsko; • GO:0009327 makromolekulani kompleks;
Biološki proces	• animal organ development; • negative regulation of meiotic cell cycle; • regulation of cardiac conduction; • growth plate cartilage chondrocyte proliferation; • response to hypoxia; • ossification; • regulation of multicellular organism growth; • negative regulation of oocyte maturation; • growth plate cartilage chondrocyte differentiation; • post-embryonic development; • receptor guanylyl cyclase signaling pathway; • regulation of smooth muscle cell proliferation; • cGMP biosynthetic process; • positive regulation of osteoblast differentiation; • negative regulation of DNA metabolic process; • response to ethanol; • negative regulation of cell population proliferation; • Savijanje proteina; • regulation of signaling receptor activity; • reproductive process; • cGMP-mediated signaling; • positive regulation of cGMP-mediated signaling; • negative regulation of collagen biosynthetic process; • negative regulation of DNA biosynthetic process;
	Izvori:Amigo / QuickGO
Ortolozi
	4880
	18159
	ENSG00000163273
	ENSMUSG00000026241
	P23582
	Q61839
	NM_024409
	NM_010933
	NP_077720
	NP_035063
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Naturiuretski prekursorni peptid C ili prekursorni natriuretski peptid C, poznat i kao NPPC, je protein koji je kod ljudi kodiran genom NPPC.^[5]^[6]^[7] Prekursorski NPPC protein se cijepa na 22 aminokiselinski peptid natriuretski peptid tipa C (CNP).

Funkcija[uredi | uredi izvor]

Natriuretski peptidi čine porodicu od tri strukturno srodne molekule: pretkomorski (ANP), komorski (BNP) i C-tip natriuretskog peptida (CNP), kodiranih genom koga simbolizira skraćenica NPPC. Ovi peptidi imaju snažne natriuretske, diuretske i vazodilatacijske aktivnosti i uključeni su u homeostazu tjelesne tečnosti i kontrolu krvnog pritiska. Za razliku od ANP i BNP, CNP nema direktnu natriuretsku aktivnost. To je zato što je CNP selektivni agonist za natriuretski receptor B-tipa (NPRB), dok su ANP i BNP selektivni za natriuretski receptor A-tipa (NPRA).^[8] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO) and certain proinflammatory cytokines.^[9]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NPPC natriuretic peptide precursor C".
^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (maj 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (novembar 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.
^ Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

Dopunska literatura[uredi | uredi izvor]

Schulz S (juni 2005). "C-type natriuretic peptide and guanylyl cyclase B receptor". Peptides. 26 (6): 1024–34. doi:10.1016/j.peptides.2004.08.027. PMID 15911070.
Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K (januar 1992). "Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide". Endocrinology. 130 (1): 229–39. doi:10.1210/en.130.1.229. PMID 1309330.
Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H (juni 1992). "Human C-type natriuretic peptide. Characterization of the gene and peptide". Hypertension. 19 (6 Pt 2): 809–13. doi:10.1161/01.hyp.19.6.809. PMID 1339402.
Ishizaka Y, Kangawa K, Minamino N, Ishii K, Takano S, Eto T, Matsuo H (decembar 1992). "Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1". Biochemical and Biophysical Research Communications. 189 (2): 697–704. doi:10.1016/0006-291X(92)92257-X. PMID 1472040.
Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N (august 1991). "C-type natriuretic peptide (CNP) in rats and humans". Endocrinology. 129 (2): 1104–6. doi:10.1210/endo-129-2-1104. PMID 1855454.
Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H (mart 1991). "Gene and precursor structures of human C-type natriuretic peptide". Biochemical and Biophysical Research Communications. 175 (2): 645–51. doi:10.1016/0006-291X(91)91614-I. PMID 2018508.
Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (novembar 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (maj 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.
Wei CM, Heublein DM, Perrella MA, Lerman A, Rodeheffer RJ, McGregor CG, Edwards WD, Schaff HV, Burnett JC (septembar 1993). "Natriuretic peptide system in human heart failure". Circulation. 88 (3): 1004–9. doi:10.1161/01.cir.88.3.1004. PMID 8353861.
Igaki T, Itoh H, Suga S, Komatsu Y, Ogawa Y, Doi K, Yoshimasa T, Nakao K (juli 1996). "Insulin suppresses endothelial secretion of C-type natriuretic peptide, a novel endothelium-derived relaxing peptide". Diabetes. 45 Suppl 3: S62–4. doi:10.2337/diab.45.3.s62. PMID 8674895.
Igaki T, Itoh H, Suga S, Hama N, Ogawa Y, Komatsu Y, Mukoyama M, Sugawara A, Yoshimasa T, Tanaka I, Nakao K (juni 1996). "C-type natriuretic peptide in chronic renal failure and its action in humans". Kidney International Supplements. 55: S144–7. PMID 8743538.
Vollmar AM, Paumgartner G, Gerbes AL (januar 1997). "Differential gene expression of the three natriuretic peptides and natriuretic peptide receptor subtypes in human liver". Gut. 40 (1): 145–50. doi:10.1136/gut.40.1.145. PMC 1027025. PMID 9155593.
Watanabe Y, Nakajima K, Shimamori Y, Fujimoto Y (juni 1997). "Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.11". Biochemical and Molecular Medicine. 61 (1): 47–51. doi:10.1006/bmme.1997.2584. PMID 9232196.
Martick MM, Garcia KC (august 2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone". Science. 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490.
Cataliotti A, Giordano M, De Pascale E, Giordano G, Castellino P, Jougasaki M, Costello LC, Boerrigter G, Tsuruda T, Belluardo P, Lee SC, Huntley B, Sandberg S, Malatino LS, Burnett JC (septembar 2002). "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". American Journal of Physiology. Renal Physiology. 283 (3): F464–72. doi:10.1152/ajprenal.00372.2001. PMID 12167597.
Evans JJ, Youssef AH, Yandle TG, Lewis LK, Nicholls MG (oktobar 2002). "Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells". The Journal of Endocrinology. 175 (1): 225–32. doi:10.1677/joe.0.1750225. PMID 12379507.
Ono K, Mannami T, Baba S, Tomoike H, Suga S, Iwai N (septembar 2002). "A single-nucleotide polymorphism in C-type natriuretic peptide gene may be associated with hypertension". Hypertension Research. 25 (5): 727–30. doi:10.1291/hypres.25.727. PMID 12452325.
Hirsch JR, Skutta N, Schlatter E (august 2003). "Signaling and distribution of NPR-Bi, the human splice form of the natriuretic peptide receptor type B". American Journal of Physiology. Renal Physiology. 285 (2): F370–4. doi:10.1152/ajprenal.00049.2003. PMID 12709393.
Wu C, Wu F, Pan J, Morser J, Wu Q (juli 2003). "Furin-mediated processing of Pro-C-type natriuretic peptide". The Journal of Biological Chemistry. 278 (28): 25847–52. doi:10.1074/jbc.M301223200. PMID 12736257.

Također pogledajte[uredi | uredi izvor]

Vanjski linkovi[uredi | uredi izvor]

C-Type Natriuretic Peptide na US National Library of Medicine Medical Subject Headings (MeSH)

Commons logo

Commons ima datoteke na temu: Natriuretski prekursorni peptid C

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163273 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026241 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: NPPC natriuretic peptide precursor C".

[pmid8330189-6] Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (maj 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189.

[pmid7698765-7] Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (novembar 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.

[pmid8959763-8] Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763.

[pmid21247399-9] Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

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