SLITRK2

SLITRK2
Identifikatori
Aliasi	SLITRK2
Vanjski ID-jevi	OMIM: 300561 MGI: 2679449 HomoloGene: 13054 GeneCards: SLITRK2
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	145,829,856 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	65,704,999 bp
Obrazac RNK ekspresije
	; ; ; ;
	Više referentnih podataka o ekspresiji
Ortolozi
	84631
	245450
	ENSG00000185985
	ENSMUSG00000036790
	Q9H156
	Q810C0
NM_001144003; NM_001144004; NM_001144005; NM_001144006; NM_001144007;
	NM_001144008; NM_001144009; NM_001144010; NM_032539
	NM_001161431; NM_198863
NP_001137475; NP_001137476; NP_001137477; NP_001137478; NP_001137480;
	NP_001137481; NP_001137482; NP_115928
	NP_001154903; NP_942563
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

SLIT i NTRK-oliki protein 2 je protein koji je kod ljudi kodiran genom SLITRK2.^[5]^[6]^[7]

Funkcija

Članovi porodice SLITRK, kao što je SLITRK2, integralni su membranski proteini sa dva N-krajnja domena ponovljnj bogata leucinom (LRR), sličnim domenima SLIT-proteina. ( vidi SLIT1; MIM 603742). Većina SLITRK-a, uključujući SLITRK2, takođe imaju C-krajeve regije koje imaju homologiju sa neurotrofinskim receptorima (vidi NTRK1; MIM 191315). SLITRK se pretežno eksprimiraju u neuronskim tkivima i imaju neuritsko-modulacijsku aktivnost.^[6]^[7]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185985 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036790 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (april 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
^ ^a ^b Aruga J, Yokota N, Mikoshiba K (oktobar 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.
^ ^a ^b "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

Dopunska literatura

Bonaldo MF, Lennon G, Soares MB (septembar 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185985 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036790 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11347906-5] Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O (april 2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.

[Aruga_2003-6] Aruga J, Yokota N, Mikoshiba K (oktobar 2003). "Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue". Gene. 315: 87–94. doi:10.1016/S0378-1119(03)00715-7. PMID 14557068.

[entrez-7] "Entrez Gene: SLITRK2 SLIT and NTRK-like family, member 2".

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