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Protein FERM sa domenom 4B jest protein koji je kod ljudi kodiran genom FRMD4B sa hromosoma 3 .[ 2]
Dužina polipeptidnog lanca je 1.034 aminokiseline , а molekulska težina 118.047 Da .[ 3]
10 20 30 40 50 MASVFMCGVE DLLFSGSRFV WNLTVSTLRR WYTERLRACH QVLRTWCGLQ DVYQMTEGRH CQVHLLDDRR LELLVQPKLL ARELLDLVAS HFNLKEKEYF GITFIDDTGQ QNWLQLDHRV LDHDLPKKPG PTILHFAVRF YIESISFLKD KTTVELFFLN AKACVHKGQI EVESETIFKL AAFILQEAKG DYTSDENARK DLKTLPAFPT KTLQEHPSLA YCEDRVIEHY LKIKGLTRGQ AVVQYMKIVE ALPTYGVHYY AVKDKQGLPW WLGISYKGIG QYDIQDKVKP RKLFQWKQLE NLYFREKKFA VEVHDPRRIS VSRRTFGQSG LFVQTWYANS SLIKSIWVMA ISQHQFYLDR KQSKAKIPSA RSLDEIAMDL TETGTQRASK LVTLETKSQF IMASNGSLIS SGSQDSEVSE EQKREKILEL KKKEKLLQEK LLKKVEELKK ICLREAELTG KMPKEYPLNI GEKPPQVRRR VGTAFKLDDN LLPSEEDPAL QELESNFLIQ QKLVEAAKKL ANEPDLCKTV KKKRKQDYTD AMKKLQEIEN AINEYRIRCG KKPSQKATVL PEDIIPSESS SLSDTTTYDD PSDAFTFPGQ RSSSVPHSPR ILPPKSLGIE RIHFRKSSIN EQFVDTRQSR EMLSTHSSPY KTLERRPQGG RSMPTTPVLT RNAYSSSHLE PESSSQHCRQ RSGSLESQSH LLSEMDSDKP FFSLSKSQRS SSTEILDDGS SYTSQSSTEY YCVTPVTGPY YTTQTLDTRT RGRRRSKKQN VSTSNSGSMP NLAQKDSLRN GVYSKSQEPP SSSYYIAGYT PYAECDFYYS GGYVYENDTE GQYSVNPSYR SSAHYGYERQ RDYSRSFHED EVDRVPHNPY ATLRLPRKAA AKSEHITKNI HKALVAEHLR GWYQRASGQK DQGHSPQTSF DSDRGSQRCL GFAGLQVPCS PSSRASSYSS VSSTNASGNW RTQLTIGLSD YETPAHSSYT SCYGNVYNPL PSPSRQYTEI SQLDGTDGNQ LEDNLESSEQ RLFWHEDSKP GTLV
Ovaj gen kodira GRP1-vezujući protein koji sadrži domen interakcije proteina FERM, kao i dva domena upredene zavojnice . Ovaj protein može imati ulogu proteina skele.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . Am. J. Hum. Genet . 85 (5): 628–42. doi :10.1016/j.ajhg.2009.10.014 . PMC 2775832 PMID 19913121 . Cappola TP, Li M, He J, Ky B, Gilmore J, Qu L, Keating B, Reilly M, Kim CE, Glessner J, Frackelton E, Hakonarson H, Syed F, Hindes A, Matkovich SJ, Cresci S, Dorn GW (2010). "Common variants in HSPB7 and FRMD4B associated with advanced heart failure" . Circ Cardiovasc Genet . 3 (2): 147–54. doi :10.1161/CIRCGENETICS.109.898395 . PMC 2957840 PMID 20124441 . Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score" . Mol. Med . 16 (7–8): 247–53. doi :10.2119/molmed.2009.00159 . PMC 2896464 PMID 20379614 . Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study" . Diabetes Care . 33 (10): 2250–3. doi :10.2337/dc10-0452 . PMC 2945168 PMID 20628086 . Matkovich SJ, Van Booven DJ, Cappola TP, Dorn GW (2010). "Association of an intronic, but not any exonic, FRMD4B sequence variant and heart failure" . Clin Transl Sci . 3 (4): 134–9. doi :10.1111/j.1752-8062.2010.00220.x . PMC 2925316 PMID 20718813 .
Ovaj članak uključuje tekst iz Nacionalne medicinske biblioteke Sjedinjenih Država , koji je u javnom vlasništvu .
