OMG (gen)

OMG (gen)
Identifikatori
Aliasi	OMG
Vanjski ID-jevi	OMIM: 164345 MGI: 106586 HomoloGene: 36099 GeneCards: OMG
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	79,394,910 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ortolozi
	4974
	18377
	n/a
	ENSMUSG00000049612
	P23515
	Q63912
	NM_002544
	NM_019409
	NP_002535
	NP_062282
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Oligodendrocitno-mijelinski glikoprotein je protein koji je kod ljudi kodiran genom OMG.^[4]^[5]^[6]

Dužina polipeptidnog lanca je 440 aminokiselina, sa molekulskom težinom od 49.608.^[7]

Aminokiselinska sekvenca

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MEYQILKMSL	CLFILLFLTP	GILCICPLQC	ICTERHRHVD	CSGRNLSTLP
SGLQENIIHL	NLSYNHFTDL	HNQLTQYTNL	RTLDISNNRL	ESLPAHLPRS
LWNMSAANNN	IKLLDKSDTA	YQWNLKYLDV	SKNMLEKVVL	IKNTLRSLEV
LNLSSNKLWT	VPTNMPSKLH	IVDLSNNSLT	QILPGTLINL	TNLTHLYLHN
NKFTFIPDQS	FDQLFQLQEI	TLYNNRWSCD	HKQNITYLLK	WMMETKAHVI
GTPCSTQISS	LKEHNMYPTP	SGFTSSLFTV	SGMQTVDTIN	SLSVVTQPKV
TKIPKQYRTK	ETTFGATLSK	DTTFTSTDKA	FVPYPEDTST	ETINSHEAAA
ATLTIHLQDG	MVTNTSLTSS	TKSSPTPMTL	SITSGMPNNF	SEMPQQSTTL
NLWREETTTN	VKTPLPSVAN	AWKVNASFLL	LLNVVVMLAV

Reference

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049612 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Viskochil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R (Mar 1991). "The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene". Mol Cell Biol. 11 (2): 906–12. doi:10.1128/mcb.11.2.906. PMC 359746. PMID 1899288.
^ Mikol DD, Alexakos MJ, Bayley CA, Lemons RS, Le Beau MM, Stefansson K (Mar 1991). "Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein". J Cell Biol. 111 (6 Pt 1): 2673–9. doi:10.1083/jcb.111.6.2673. PMC 2116377. PMID 2277079.
^ "Entrez Gene: OMG oligodendrocyte myelin glycoprotein".
^ "UniProt, P23515". Pristupljeno 12. 9. 2017.

Dopunska literatura

Mikol DD, Gulcher JR, Stefansson K (1990). "The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate". J. Cell Biol. 110 (2): 471–9. doi:10.1083/jcb.110.2.471. PMC 2116011. PMID 1688857.
Mikol DD, Stefansson K (1988). "A phosphatidylinositol-linked peanut agglutinin-binding glycoprotein in central nervous system myelin and on oligodendrocytes". J. Cell Biol. 106 (4): 1273–9. doi:10.1083/jcb.106.4.1273. PMC 2115011. PMID 3283151.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mikol DD, Rongnoparut P, Allwardt BA, et al. (1993). "The oligodendrocyte-myelin glycoprotein of mouse: primary structure and gene structure". Genomics. 17 (3): 604–10. doi:10.1006/geno.1993.1379. PMID 8244377.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wang KC, Koprivica V, Kim JA, et al. (2002). "Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth". Nature. 417 (6892): 941–4. doi:10.1038/nature00867. PMID 12068310. S2CID 5734715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Vourc'h P, Moreau T, Arbion F, et al. (2003). "Oligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor". J. Neurochem. 85 (4): 889–97. doi:10.1046/j.1471-4159.2003.01764.x. PMID 12716421. S2CID 30250786.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Venturin M, Moncini S, Villa V, et al. (2007). "Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation" (PDF). Neurogenetics. 7 (1): 59–66. doi:10.1007/s10048-005-0026-9. hdl:2434/10108. PMID 16425041. S2CID 24738309.
Douglas J, Cilliers D, Coleman K, et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. S2CID 35797973.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000049612 - Ensembl, maj 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1899288-4] Viskochil D, Cawthon R, O'Connell P, Xu GF, Stevens J, Culver M, Carey J, White R (Mar 1991). "The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene". Mol Cell Biol. 11 (2): 906–12. doi:10.1128/mcb.11.2.906. PMC 359746. PMID 1899288.

[pmid2277079-5] Mikol DD, Alexakos MJ, Bayley CA, Lemons RS, Le Beau MM, Stefansson K (Mar 1991). "Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein". J Cell Biol. 111 (6 Pt 1): 2673–9. doi:10.1083/jcb.111.6.2673. PMC 2116377. PMID 2277079.

[entrez-6] "Entrez Gene: OMG oligodendrocyte myelin glycoprotein".

[UniProt-7] "UniProt, P23515". Pristupljeno 12. 9. 2017.

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