CALCOCO1

CALCOCO1
Identifikatori
Aliasi	CALCOCO1
Vanjski ID-jevi	MGI: 1914738 HomoloGene: 10845 GeneCards: CALCOCO1
Lokacija gena (čovjek)
Hrom.	Hromosom 12 (čovjek)
Kraj	53,727,745 bp
Lokacija gena (miš)
Hrom.	Hromosom 15 (miš)
Kraj	102,630,613 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• sequence-specific DNA binding; • beta-catenin binding; • GO:0001105 transcription coactivator activity; • chromatin binding; • GO:0001104 transcription coregulator activity; • protein C-terminus binding; • GO:0001948, GO:0016582 vezivanje za proteine; • nuclear receptor coactivator activity; • armadillo repeat domain binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Ćelijska komponenta	• intracellular membrane-bounded organelle; • jedro; • citoplazma; • citosol;
Biološki proces	• GO:0009373 regulation of transcription, DNA-templated; • intracellular steroid hormone receptor signaling pathway; • Wnt-signalni put; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • GO:0072468 Transdukcija signala; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • GO:1901313 positive regulation of gene expression;
	Izvori:Amigo / QuickGO
Ortolozi
	57658
	67488
	ENSG00000012822
	ENSMUSG00000023055
	Q9P1Z2
	Q8CGU1
	NM_001143682; NM_020898
	NM_026192
	NP_001137154; NP_065949
	NP_080468
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 kalcijskog vezanja sa domenom upredene zavojnice je protein koji je kod ljudi kodiran genom CALCOCO1.^[5]^[6]^[7]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 691 aminokiselina, a molekulska težina 77.336 Da.^[8].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin

I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MEESPLSRAP	SRGGVNFLNV	ARTYIPNTKV	ECHYTLPPGT	MPSASDWIGI
FKVEAACVRD	YHTFVWSSVP	ESTTDGSPIH	TSVQFQASYL	PKPGAQLYQF
RYVNRQGQVC	GQSPPFQFRE	PRPMDELVTL	EEADGGSDIL	LVVPKATVLQ
NQLDESQQER	NDLMQLKLQL	EGQVTELRSR	VQELERALAT	ARQEHTELME
QYKGISRSHG	EITEERDILS	RQQGDHVARI	LELEDDIQTI	SEKVLTKEVE
LDRLRDTVKA	LTREQEKLLG	QLKEVQADKE	QSEAELQVAQ	QENHHLNLDL
KEAKSWQEEQ	SAQAQRLKDK	VAQMKDTLGQ	AQQRVAELEP	LKEQLRGAQE
LAASSQQKAT	LLGEELASAA	AARDRTIAEL	HRSRLEVAEV	NGRLAELGLH
LKEEKCQWSK	ERAGLLQSVE	AEKDKILKLS	AEILRLEKAV	QEERTQNQVF
KTELAREKDS	SLVQLSESKR	ELTELRSALR	VLQKEKEQLQ	EEKQELLEYM
RKLEARLEKV	ADEKWNEDAT	TEDEEAAVGL	SCPAALTDSE	DESPEDMRLP
PYGLCERGDP	GSSPAGPREA	SPLVVISQPA	PISPHLSGPA	EDSSSDSEAE
DEKSVLMAAV	QSGGEEANLL	LPELGSAFYD	MASGFTVGTL	SETSTGGPAT
PTWKECPICK	ERFPAESDKD	ALEDHMDGHF	FFSTQDPFTF	E

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000012822 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023055 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: CALCOCO1 calcium binding and coiled-coil domain 1".
^ "UniProt, Q9P1Z2". Pristupljeno 7. 8. 2021.

Dopunska literatura[uredi | uredi izvor]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee SY, Obata Y, Yoshida M, et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–6. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Takahashi K, Inuzuka M, Ingi T (2005). "Cellular signaling mediated by calphoglin-induced activation of IPP and PGM". Biochem. Biophys. Res. Commun. 325 (1): 203–14. doi:10.1016/j.bbrc.2004.10.021. PMID 15522220.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yang CK, Kim JH, Li H, Stallcup MR (2006). "Differential use of functional domains by CoCoA in its synergistic coactivator function with β-catenin or GRIP1". J. Biol. Chem. 281 (6): 3389–97. doi:10.1074/jbc.M510403200. PMC 1626527. PMID 16344550.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Yang CK, Kim JH, Stallcup MR (2007). "Role of the N-terminal activation domain of coactivator CoCoA in mediating transcriptional activation by β-catenin". Mol. Endocrinol. 20 (12): 3251–62. doi:10.1210/me.2006-0200. PMC 1770943. PMID 16931570.

Vanjski linkovi[uredi | uredi izvor]

Lokacija ljudskog genoma CALCOCO1 i stranica sa detaljima o genu CALCOCO1 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000012822 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023055 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: CALCOCO1 calcium binding and coiled-coil domain 1".

[UniProt-8] "UniProt, Q9P1Z2". Pristupljeno 7. 8. 2021.

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