Endotelin 3

Endotelin 3
Identifikatori
Aliasi	EDN3
Vanjski ID-jevi	OMIM: 131242 MGI: 95285 HomoloGene: 88 GeneCards: EDN3
Lokacija gena (čovjek) Hrom. Hromosom 20 (čovjek) Bend 20q13.32 Početak 59,300,443 bp Kraj 59,325,992 bp
Lokacija gena (miš) Hrom. Hromosom 2 (miš) Bend 2 H4|2 98.1 cM Početak 174,602,412 bp Kraj 174,625,835 bp
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • hormone activity • endothelin B receptor binding • signaling receptor binding Ćelijska komponenta • extracellular region • intracellular anatomical structure • Vanćelijsko Biološki proces • positive regulation of MAP kinase activity • regulation of systemic arterial blood pressure by endothelin • Vazokonstrikcija • cell-cell signaling • Krvotok • neutrophil chemotaxis • positive regulation of heart rate • multicellular organism development • positive regulation of leukocyte chemotaxis • cell surface receptor signaling pathway • vein smooth muscle contraction • regulation of vasoconstriction • peptide hormone secretion • positive regulation of cell differentiation • artery smooth muscle contraction • Regulacija ekspresije gena • inositol phosphate-mediated signaling • positive regulation of mitotic nuclear division • positive regulation of hormone secretion • GO:0072468 Transdukcija signala • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • neural crest cell migration • cellular calcium ion homeostasis • positive regulation of cell population proliferation • cellular magnesium ion homeostasis • neuron differentiation • melanocyte differentiation • regulation of cell migration • regulation of developmental pigmentation • positive regulation of potassium ion transmembrane transport Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	1908	13616
Ensembl	ENSG00000124205	ENSMUSG00000027524
UniProt	P14138	P48299
RefSeq (mRNK)	NM_000114 NM_207032 NM_207033 NM_207034 NM_001302455 NM_001302456	NM_007903
RefSeq (bjelančevina)	NP_001289384 NP_001289385 NP_996915 NP_996916 NP_996917	NP_031929
Lokacija (UCSC)	Chr 20: 59.3 – 59.33 Mb	Chr 2: 174.6 – 174.63 Mb
PubMed pretraga
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Endotelin-3 je protein, koji je kod ljudi kodiran genom EDN3.

Protein koji kodira ovaj gen član je porodice endotelina. Endotelini su vazoaktivni peptidi izvedeni iz endotela koji su uključeni u razne biološke funkcije. Aktivni oblik ovog proteina je peptid od 21 aminokiseline, prerađen iz proteina preteče. Aktivni peptid je ligand za endotelinski receptor tip B (EDNRB). Interakcija ovog endotelina s EDNRB od suštinske je važnosti za razvoj ćelijskih loza izvedenih iz nrvnog grebena, kao što su melanociti i crijevni neuroni. Mutacije u ovom genu i EDNRB povezane su sa Hirschsprungovom bolešću (HSCR) i Waardenburgovim sindromom (WS), koji su urođeni poremećaji koji uključuju ćelije izvedene iz nervnog grebena. Uočene su četiri alternativno prerađene varijante transkripta, koje kodiraju tri različite izoforme.

Dopunska literatura

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