HEATR1

HEATR1
Identifikatori
Aliasi	HEATR1
Vanjski ID-jevi	MGI: 2442524 HomoloGene: 34562 GeneCards: HEATR1
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	236,604,516 bp
Lokacija gena (miš)
Hrom.	Hromosom 13 (miš)
Kraj	12,455,170 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • snoRNA binding; • vezivanje sa RNK;
Ćelijska komponenta	• small-subunit processome; • membrana; • mitohondrija; • 90S preribosome; • t-UTP complex; • nukleoplazma; • fibrillar center; • jedro; • Jedarce;
Biološki proces	• maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); • ribosome biogenesis; • rRNA processing; • positive regulation of rRNA processing; • transcription, DNA-templated; • GO:0009373 regulation of transcription, DNA-templated; • positive regulation of transcription by RNA polymerase I;
	Izvori:Amigo / QuickGO
Ortolozi
	55127
	217995
	ENSG00000119285
	ENSMUSG00000050244
	Q9H583
	G3X9B1
	NM_018072
	NM_144835
	NP_060542; NP_060542.4
	NP_659084
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 1 sa HEAT-ponavljanjem jest protein koji je kod ljudi kodiran genom HEATR1 sa hromosoma 1.^[5]^[6]

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 2.144 aminokiseline, a molekulska težina 242. 370 Da.^[7]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MTSLAQQLQR	LALPQSDASL	LSRDEVASLL	FDPKEAATID	RDTAFAIGCT
GLEELLGIDP	SFEQFEAPLF	SQLAKTLERS	VQTKAVNKQL	DENISLFLIH
LSPYFLLKPA	QKCLEWLIHR	FHIHLYNQDS	LIACVLPYHE	TRIFVRVIQL
LKINNSKHRW	FWLLPVKQSG	VPLAKGTLIT	HCYKDLGFMD	FICSLVTKSV
KVFAEYPGSS	AQLRVLLAFY	ASTIVSALVA	AEDVSDNIIA	KLFPYIQKGL
KSSLPDYRAA	TYMIICQISV	KVTMENTFVN	SLASQIIKTL	TKIPSLIKDG
LSCLIVLLQR	QKPESLGKKP	FPHLCNVPDL	ITILHGISET	YDVSPLLHYM
LPHLVVSIIH	HVTGEETEGM	DGQIYKRHLE	AILTKISLKN	NLDHLLASLL
FEEYISYSSQ	EEMDSNKVSL	LNEQFLPLIR	LLESKYPRTL	DVVLEEHLKE
IADLKKQELF	HQFVSLSTSG	GKYQFLADSD	TSLMLSLNHP	LAPVRILAMN
HLKKIMKTSK	EGVDESFIKE	AVLARLGDDN	IDVVLSAISA	FEIFKEHFSS
EVTISNLLNL	FQRAELSKNG	EWYEVLKIAA	DILIKEEILS	ENDQLSNQVV
VCLLPFMVIN	NDDTESAEMK	IAIYLSKSGI	CSLHPLLRGW	EEALENVIKS
TKPGKLIGVA	NQKMIELLAD	NINLGDPSSM	LKMVEDLISV	GEEESFNLKQ
KVTFHVILSV	LVSCCSSLKE	THFPFAIRVF	SLLQKKIKKL	ESVITAVEIP
SEWHIELMLD	RGIPVELWAH	YVEELNSTQR	VAVEDSVFLV	FSLKKFIYAL
KAPKSFPKGD	IWWNPEQLKE	DSRDYLHLLI	GLFEMMLNGA	DAVHFRVLMK
LFIKVHLEDV	FQLFKFCSVL	WTYGSSLSNP	LNCSVKTVLQ	TQALYVGCAM
LSSQKTQCKH	QLASISSPVV	TSLLINLGSP	VKEVRRAAIQ	CLQALSGVAS
PFYLIIDHLI	SKAEEITSDA	AYVIQDLATL	FEELQREKKL	KSHQKLSETL
KNLLSCVYSC	PSYIAKDLMK	VLQGVNGEMV	LSQLLPMAEQ	LLEKIQKEPT
AVLKDEAMVL	HLTLGKYNEF	SVSLLNEDPK	SLDIFIKAVH	TTKELYAGMP
TIQITALEKI	TKPFFAAISD	EKVQQKLLRM	LFDLLVNCKN	SHCAQTVSSV
FKGISVNAEQ	VRIELEPPDK	AKPLGTVQQK	RRQKMQQKKS	QDLESVQEVG
GSYWQRVTLI	LELLQHKKKL	RSPQILVPTL	FNLLSRCLEP	LPQEQGNMEY
TKQLILSCLL	NICQKLSPDG	GKIPKDILDE	EKFNVELIVQ	CIRLSEMPQT
HHHALLLLGT	VAGIFPDKVL	HNIMSIFTFM	GANVMRLDDT	YSFQVINKTV
KMVIPALIQS	DSGDSIEVSR	NVEEIVVKII	SVFVDALPHV	PEHRRLPILV
QLVDTLGAEK	FLWILLILLF	EQYVTKTVLA	AAYGEKDAIL	EADTEFWFSV
CCEFSVQHQI	QSLMNILQYL	LKLPEEKEET	IPKAVSFNKS	ESQEEMLQVF
NVETHTSKQL	RHFKFLSVSF	MSQLLSSNNF	LKKVVESGGP	EILKGLEERL
LETVLGYISA	VAQSMERNAD	KLTVKFWRAL	LSKAYDLLDK	VNALLPTETF
IPVIRGLVGN	PLPSVRRKAL	DLLNNKLQQN	ISWKKTIVTR	FLKLVPDLLA
IVQRKKKEGE	EEQAINRQTA	LYTLKLLCKN	FGAENPDPFV	PVLNTAVKLI
APERKEEKNV	LGSALLCIAE	VTSTLEALAI	PQLPSLMPSL	LTTMKNTSEL
VSSEVYLLSA	LAALQKVVET	LPHFISPYLE	GILSQVIHLE	KITSEMGSAS
QANIRLTSLK	KTLATTLAPR	VLLPAIKKTY	KQIEKNWKNH	MGPFMSILQE
HIGVMKKEEL	TSHQSQLTAF	FLEALDFRAQ	HSENDLEEVG	KTENCIIDCL
VAMVVKLSEV	TFRPLFFKLF	DWAKTEDAPK	DRLLTFYNLA	DCIAEKLKGL
FTLFAGHLVK	PFADTLNQVN	ISKTDEAFFD	SENDPEKCCL	LLQFILNCLY
KIFLFDTQHF	ISKERAEALM	MPLVDQLENR	LGGEEKFQER	VTKHLIPCIA
QFSVAMADDS	LWKPLNYQIL	LKTRDSSPKV	RFAALITVLA	LAEKLKENYI
VLLPESIPFL	AELMEDECEE	VEHQCQKTIQ	QLETVLGEPL	QSYF

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119285 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050244 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
^ "Entrez Gene: HEATR1 HEAT repeat containing 1".
^ "UniProt, Q9H583" (jezik: en.). Pristupljeno 12. 12. 2021.CS1 održavanje: nepoznati jezik (link)

Dopunska literatura[uredi | uredi izvor]

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Xie H, Diber A, Pollock S, et al. (2004). "Bridging expressed sequence alignments through targeted cDNA sequencing". Genomics. 83 (4): 572–6. doi:10.1016/j.ygeno.2003.07.003. PMID 15028280.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000119285 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050244 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: HEATR1 HEAT repeat containing 1".

[UniProt-7] "UniProt, Q9H583" (jezik: en.). Pristupljeno 12. 12. 2021.CS1 održavanje: nepoznati jezik (link)

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