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HRC

S Wikipedije, slobodne enciklopedije
HRC
Identifikatori
AliasiHRC
Vanjski ID-jeviOMIM: 142705 HomoloGene: 135866 GeneCards: HRC
Lokacija gena (čovjek)
Hromosom 19 (čovjek)
Hrom.Hromosom 19 (čovjek)[1]
Hromosom 19 (čovjek)
Genomska lokacija za HRC
Genomska lokacija za HRC
Bend19q13.33Početak49,151,198 bp[1]
Kraj49,155,396 bp[1]
Ontologija gena
Molekularna funkcija ATPase binding
transmembrane transporter binding
GO:0001948, GO:0016582 vezivanje za proteine
calcium ion binding
Ćelijska komponenta sarcoplasmic reticulum lumen
Sarkoplazmatski retikulum
Z discdkac
sarcoplasmic reticulum membrane
endoplasmic reticulum lumen
Biološki proces Mišićna kontrakcija
regulation of ryanodine-sensitive calcium-release channel activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of relaxation of cardiac muscle
regulation of heart rate
regulation of calcium ion transmembrane transport
positive regulation of heart rate
calcium ion homeostasis
regulation of peptidyl-serine phosphorylation
regulation of heart contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cytosolic calcium ion concentration
positive regulation of heart contraction
regulation of cell communication by electrical coupling involved in cardiac conduction
Posttranslacione modifikacije
negative regulation of cytosolic calcium ion concentration
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_002152

n/a

RefSeq (bjelančevina)

NP_002143

n/a

Lokacija (UCSC)Chr 19: 49.15 – 49.16 Mbn/a
PubMed pretraga[2]n/a
Wikipodaci
Pogledaj/uredi – čovjek

Histidinom bogati kalcij-vezujući protein sarkoplazmatskog retikuluma je protein koji je kod ljudi kodiran genom HRC.[3][4]

Aminokiselinska sekvenca

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Simboli
1020304050
MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLS
EEASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYG
HLLPGHRSQDHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRH
HLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEE
EEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRHQGHEEDDDDD
DDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSH
EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRD
EEEDEDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHK
SDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDEET
GHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDE
SSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEE
RREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA
SSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMG
EHCDQCQHCQFCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP

Funkcija

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Protein koji veže kalcijem bogati histidin je luminalni protein sarkoplazmatskog retikuluma od 165 kD, prepoznatljiv po svojoj sposobnosti da veže lipoprotein male gustoće, sa visokim afinitetom.[4]

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130528 - Ensembl, maj 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Hofmann SL, Topham M, Hsieh CL, Francke U (Apr 1991). "cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7". Genomics. 9 (4): 656–69. doi:10.1016/0888-7543(91)90359-M. PMID 2037293.
  4. ^ a b "Entrez Gene: HRC histidine rich calcium binding protein".

Dopunska literatura

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