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RRP12

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RRP12
Identifikatori
AliasiRRP12
Vanjski ID-jeviOMIM: 617723 MGI: 2147437 HomoloGene: 22370 GeneCards: RRP12
Lokacija gena (čovjek)
Hromosom 10 (čovjek)
Hrom.Hromosom 10 (čovjek)[1]
Hromosom 10 (čovjek)
Genomska lokacija za RRP12
Genomska lokacija za RRP12
Bend10q24.1Početak97,356,358 bp[1]
Kraj97,426,076 bp[1]
Lokacija gena (miš)
Hromosom 19 (miš)
Hrom.Hromosom 19 (miš)[2]
Hromosom 19 (miš)
Genomska lokacija za RRP12
Genomska lokacija za RRP12
Bend19|19 C3Početak41,851,290 bp[2]
Kraj41,884,612 bp[2]
Obrazac RNK ekspresije


Više referentnih podataka o ekspresiji
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001145114
NM_001284337
NM_015179

NM_199447

RefSeq (bjelančevina)

NP_001138586
NP_001271266
NP_055994

NP_955518

Lokacija (UCSC)Chr 10: 97.36 – 97.43 MbChr 19: 41.85 – 41.88 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

RRP12-oliki protein je protein koji je kod ljudi kodiran genom RRP12.[5][6] Smatra se da je uključen u ribosomski skup prekursorskih čestica obje podjedinice u eukariotima i identificiran je kao RNK-vezani protein.[7][8]

Aminokiselinska sekvenca

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Dužina polipeptidnog lanca je 1.297 aminokiselina, а molekulska težina 143.702 Da.[9]

1020304050
MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSRPSGRSD
LTVDAVKLHNELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLS
DCTNVTFSKVQRFWESNSAAHKEICAVLAAVTEVIRSQGGKETETEYFAA
LMTTMEAVESPESLAAVAYLLNLVLKRVPSPVLIKKFSDTSKAFMDIMSA
QASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTLQVYHGLLSFTVHPKP
KIRKAAQHGVCSVLKGSEFMFEKAPAHHPAAISTAKFCIQEIEKSGGSKE
ATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQAFH
SLFHARPGLSTLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHIN
LVRLQWDLGLGHLPRFFGTAVTCLLSPHSQVLTAATQSLKEILKECVAPH
MADIGSVTSSASGPAQSVAKMFRAVEEGLTYKFHAAWSSVLQLLCVFFEA
CGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVTSMGPEVVLQA
VPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKA
MDLAQAGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMA
ISERPDLRVTVCQALRTLITKGCQAEADRAEVSRFAKNFLPILFNLYGQP
VAAGDTPAPRRAVLETIRTYLTITDTQLVNSLLEKASEKVLDPASSDFTR
LSVLDLVVALAPCADEAAISKLYSTIRPYLESKAHGVQKKAYRVLEEVCA
SPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCLLHIVRKLSAE
HKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQ
CYLVLIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLL
LASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQLVMEAIGKLSDDMRRHF
RMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARAKRHRALSQ
AAVEEEEEEEEEEEPAQGKGDSIEEILADSEDEEDNEEEERSRGKEQRKL
ARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGRKKDHGFKVSA
DGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKE
AEEEELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDP
YAYIPLNRSKLNRRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP

Reference

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000052749 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035049 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (juni 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ "Entrez Gene: RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)".
  7. ^ Oeffinger M, Dlakic M, Tollervey D (januar 2004). "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits". Genes & Development (jezik: engleski). 18 (2): 196–209. doi:10.1101/gad.285604. PMC 324425. PMID 14729571.
  8. ^ Moriggi G, Nieto B, Dosil M (decembar 2014). "Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis". PLOS Genetics. 10 (12): e1004836. doi:10.1371/journal.pgen.1004836. PMC 4256259. PMID 25474739.
  9. ^ "UniProt, Q5JTH9". Pristupljeno 4. 9. 2021.

Dopunska literatura

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