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Hromosom 10

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(Preusmjereno sa Hromosom 10 (čovjek))
Hromosom 10
Par ljudskih hromosoma 10 nakon G-pruganja.
Jedan j od majke, drugi od oca
Karakteristike
Dužina (bp)133,797,422 bp
(GRCh38)[1]
Br. gena706 (CCDS)[2]
VrstaAutosom
Pozicija centromereSubmetacentrik[3]
(39.8 Mbp)
Kompletan spisak gena
CCDSSpisak gena
HGNCSpisak gena
UniProtSpisak gena
NCBISpisak gena
Vanjski preglednici karata
EnsemblHromosom 10
EntrezHromosom 10
NCBIHromosom 10
UCSCHromosom 10
Potpune DNK sekvence
RefSeqNC_000010 (FASTA)
GenBankCM000672 (FASTA)
Par ljudskih hromosoma 10 u kariogramu muškarca

Hromosome 10 je jedan od 23 para hromosoma kod ljudi. Čovjek normalno ima njegove dvije kopije . Hromosom 10 spans ima oko 133 miliona baznih parova (gradivnog materijala DNK) i uključuje između 4 i 4,5 % ukupne DNK u ćelijama.

Geni

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Broj gena

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Slijede neke od procjena broja gena za ljudski hromosom 10. Budući da istraživači koriste različite pristupe označavanju genoma, njihova predviđanja broja gena na svakom hromosomu variraju (za tehničke detalje pogledajte predviđanje gena). Među različitim projektima, zajednički Projekt konsenzusnog kodiranja (CCDS) zauzima izuzetno konzervativnu strategiju. Dakle, predviđanje broja gena prema CCDS-u predstavlja donju granicu ukupnog broja gena koji kodiraju ljudske proteine.[4]

Baza podataka Protein-kodirajući geni Nkoirajući geni RNK Pseudogeni Izvor Datum objave
CCDS
706—— [2] 2016-09-08
HGNC
708244614 [5] 2017-05-12
Ensembl
728881568 [6] 2017-03-29
UniProt
750—— [7] 2018-02-28
NCBI
754842654 [8][9][10] 2017-05-19

Lista gena

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Slijedi djelimična lista gena na ljudskom hromosomu 10. Potpunu listu potražite u linku u informacijskom okviru s desne strane.

Bolesti i poremećaji

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Sljedeće bolesti povezane su s genima na hromosomu 10:

Citogenetičke pruge

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Isdiogram G-pruganog ljudskog hromosoma 10
Idiogram G-pruganog ljudskog hromosoma 10 u rezoluciji 850 bphs. Dužina pruga na ovom dijagramu proporcionalna je dužini osnovnog para. Ovaj tip idiograma obično se koristi u pretraživačima genoma (npr. Ensembl, UCSC pretraživač genoma.
Obrazac G-pruganja ljudskog hromosoma 10 u tri različite rezolucije (400,[11] 550[12] and 850[13]). Band length in this diagram is based on the ideograms from ISCN (2013).[14] Ovaj tip idiograma predstavlja stvarnu relativnu dužinu pruga uočenih pod mikroskopom u različitim fazama tokom procesa mitoze.[15]
G-pruge ljudskog hromosoma 10 u rezoluciji 850 bphs[13]
Hromosom Kraci: "p" – kratki ; "q" – dugi Band[16] ISCN
start[17]		 ISCN
stop[17]		 Bazni par
start		 Bazni par
stop		 Boja Gustoća
10p 15.3022913.000.000 gneg
10p 15.22293293.000.0013.800.000 gpos25
10p 15.13296303.800.0016.600.000 gneg
10p 146309176.600.00112.200.000 gpos75
10p 13917117512.200.00117.300.000 gneg
10p 12.331175136117.300.00118.300.000 gpos75
10p 12.321361143218.300.00118.400.000 gneg
10p 12.311432160418.400.00122.300.000 gpos75
10p 12.21604166222.300.00124.300.000 gneg
10p 12.11662189124.300.00129.300.000 gpos50
10p 11.231891206329.300.00131.100.000 gneg
10p 11.222063223531.100.00134.200.000 gpos25
10p 11.212235240634.200.00138.000.000 gneg
10p 11.12406262138.000.00139.800.000 acen
10q 11.12621285039.800.00141.600.000 acen
10q 11.212850305141.600.00145.500.000 gneg
10q 11.223051325245.500.00148.600.000 gpos25
10q 11.233252340948.600.00151.100.000 gneg
10q 21.13409375351.100.00159.400.000 gpos100
10q 21.23753383959.400.00162.800.000 gneg
10q 21.33839409762.800.00168.800.000 gpos100
10q 22.14097446968.800.00173.100.000 gneg
10q 22.24469465573.100.00175.900.000 gpos50
10q 22.34655497075.900.00180.300.000 gneg
10q 23.14970520080.300.00186.100.000 gpos100
10q 23.25200533186.100.00187.700.000 gneg
10q 23.315331555887.700.00191.100.000 gpos75
10q 23.325558567291.100.00192.300.000 gneg
10q 23.335672588792.300.00195.300.000 gpos50
10q 24.15887597395.300.00197.500.000 gneg
10q 24.25973613197.500.001100.100.000 gpos50
10q 24.3161316202100.100.001101.200.000 gneg
10q 24.3262026317101.200.001103.100.000 gpos25
10q 24.3363176374103.100.001104.000.000 gneg
10q 25.163746646104.000.001110.100.000 gpos100
10q 25.266466761110.100.001113.100.000 gneg
10q 25.367616890113.100.001117.300.000 gpos75
10q 26.1168907090117.300.001119.900.000 gneg
10q 26.1270907219119.900.001121.400.000 gpos50
10q 26.1372197506121.400.001125.700.000 gneg
10q 26.275067721125.700.001128.800.000 gpos50
10q 26.377218050128.800.001133.797.422 gneg
Oznake: gpos – Regija koja je pozitivno obojena G-pruganjem, uglavnom AT-bogata i siromašna genima; gneg – Regija koja je negativno obojena G-prugama, općenito CG-bogata i bogata genima; acen Centromere; var – Varijabilna regija; stalk – drška.

References

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  1. ↑ "Human Genome Assembly GRCh38 - Genome Reference Consortium". National Center for Biotechnology Information (jezik: engleski). 24. 12. 2013. Pristupljeno 4. 3. 2017.
  2. 1 2 "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene". NCBI. CCDS Release 20 for Homo sapiens. 8. 9. 2016. Pristupljeno 28. 5. 2017.
  3. ↑ Tom Strachan; Andrew Read (2. 4. 2010). Human Molecular Genetics. Garland Science. str. 45. ISBN 978-1-136-84407-2.
  4. ↑ Pertea M, Salzberg SL (2010). "Between a chicken and a grape: estimating the number of human genes". Genome Biol. 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077. PMID 20441615.
  5. ↑ "Statistics & Downloads for chromosome 10". HUGO Gene Nomenclature Committee. 12. 5. 2017. Arhivirano s originala, 29. 6. 2017. Pristupljeno 19. 5. 2017.
  6. ↑ "Chromosome 10: Chromosome summary - Homo sapiens". Ensembl Release 88. 29. 3. 2017. Pristupljeno 19. 5. 2017.
  7. ↑ "Human chromosome 10: entries, gene names and cross-references to MIM". UniProt. 28. 2. 2018. Pristupljeno 16. 3. 2018.
  8. ↑ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  9. ↑ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  10. ↑ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene". NCBI. 19. 5. 2017. Pristupljeno 20. 5. 2017.
  11. ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3). Last update 2014-03-04. Retrieved 2017-04-26.
  12. ↑ Genome Decoration Page, NCBI. Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3). Last update 2015-08-11. Retrieved 2017-04-26.
  13. 1 2 Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last update 2014-06-03. Retrieved 2017-04-26.
  14. ↑ International Standing Committee on Human Cytogenetic Nomenclature (2013). ISCN 2013: An International System for Human Cytogenetic Nomenclature (2013). Karger Medical and Scientific Publishers. ISBN 978-3-318-02253-7.
  15. ↑ Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. (2012). "Estimation of band level resolutions of human chromosome images". In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on: 276–282. doi:10.1109/JCSSE.2012.6261965. ISBN 978-1-4673-1921-8.
  16. ↑ For cytogenetic banding nomenclature, see article locus.
  17. 1 2 These values (ISCN start/stop) are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature (2013). Arbitrary unit.
  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet. 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438.
  • Gilbert F (2001). "Chromosome 10". Genet Test. 5 (1): 69–82. doi:10.1089/109065701750168824. PMID 11336406.

Također pogledajte

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Reference

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  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.CS1 održavanje: više imena: authors list (link)
  • Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet. 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438.CS1 održavanje: više imena: authors list (link)
  • Gilbert F (2001). "Chromosome 10". Genet Test. 5 (1): 69–82. doi:10.1089/109065701750168824. PMID 11336406.

Vanjski linkovi

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  • National Institutes of Health. "Chromosome 10". Genetics Home Reference. Arhivirano s originala, 8. 4. 2010. Pristupljeno 6. 5. 2017.
  • "Chromosome 10". Human Genome Project Information Archive 1990–2003. Pristupljeno 6. 5. 2017.
Preuzeto iz "https://bs.wikipedia.org/w/index.php?title=Hromosom_10&oldid=3816824"