ADAMTS1

ADAMTS1
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2JIH, 2V4B, 3Q2G, 3Q2H
Identifikatori
Aliasi	ADAMTS1
Vanjski ID-jevi	OMIM: 605174 MGI: 109249 HomoloGene: 21381 GeneCards: ADAMTS1
Lokacija gena (čovjek)
Hrom.	Hromosom 21 (čovjek)
Kraj	26,845,409 bp
Lokacija gena (miš)
Hrom.	Hromosom 16 (miš)
Kraj	85,600,001 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• heparin binding; • vezivanje iona cinka; • vezivanje iona metala; • GO:0070122 peptidase activity; • metalloendopeptidase activity; • hydrolase activity; • metallopeptidase activity;
Ćelijska komponenta	• extracellular region; • basement membrane; • GO:0016023 citoplazmatska vezikula; • GO:0005578 Vanćelijski matriks; • collagen-containing extracellular matrix;
Biološki proces	• ovulation from ovarian follicle; • heart trabecula formation; • Nefrogeneza; • Proteoliza; • integrin-mediated signaling pathway; • negative regulation of cell population proliferation; • positive regulation of G1/S transition of mitotic cell cycle; • positive regulation of vascular associated smooth muscle cell proliferation; • positive regulation of vascular associated smooth muscle cell migration;
	Izvori:Amigo / QuickGO
Ortolozi
	9510
	11504
	ENSG00000154734
	ENSMUSG00000022893
	Q9UHI8
	P97857
	NM_006988
	NM_009621
	NP_008919
	NP_033751
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Disintegrin i metaloproteinaza sa trombospondinskim motivima 1 je enzim koji je kod ljudi kodiran genom ADAMTS1.^[5]^[6]

Funkcija[uredi | uredi izvor]

Ovaj gen kodira člana proteinske porodice ADAMTS (dezintegrin i metaloproteinaza sa trombospondinskim motivom). Članovi porodice dijele nekoliko različitih proteinskih modula, uključujući propeptidnu regiju, domen metaloproteinaza, domen sličan dezintegrinu i trombospondinski (TS) motiv tipa 1. Pojedini članovi ove porodice razlikuju se u broju C-terminalnih TS motiva, a neki imaju jedinstvene C-terminalne domene. Protein kodiran ovim genom sadrži dvije dezintegrinske petlje i tri C-terminalna TS motiva i ima antiangiogeno djelovanje.

Ekspresija ovog gena može biti povezana s različitim upalnim procesima, kao i razvojem kaheksijskog raka (kaheksije). Vjerojatno je neophodan za normalan rast, plodnost i morfologiju i funkciju organa.^[6]

Interakcije[uredi | uredi izvor]

Pokazano je da ADAMTS1 ima interakcija sa faktorom vaskularnog endotelnog rasta A.^[7]

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154734 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022893 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (septembar 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.
^ ^a ^b "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".
^ Luque A, Carpizo DR, Iruela-Arispe ML (juni 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–65. doi:10.1074/jbc.M212964200. PMID 12716911.

Dopunska literatura[uredi | uredi izvor]

Tang BL, Hong W (1999). "ADAMTS: a novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats". FEBS Lett. 445 (2–3): 223–5. doi:10.1016/S0014-5793(99)00119-2. PMID 10094461.
Hirohata S (2002). "[ADAMTS family--new extracellular matrix degrading enzyme]". Seikagaku. 73 (11): 1333–7. PMID 11831030.
Kuno K, Kanada N, Nakashima E, et al. (1997). "Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene". J. Biol. Chem. 272 (1): 556–62. doi:10.1074/jbc.272.1.556. PMID 8995297.
Kuno K, Matsushima K (1998). "ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region". J. Biol. Chem. 273 (22): 13912–7. doi:10.1074/jbc.273.22.13912. PMID 9593739.
Kuno K, Terashima Y, Matsushima K (1999). "ADAMTS-1 is an active metalloproteinase associated with the extracellular matrix". J. Biol. Chem. 274 (26): 18821–6. doi:10.1074/jbc.274.26.18821. PMID 10373500.
Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
Glienke J, Schmitt AO, Pilarsky C, et al. (2000). "Differential gene expression by endothelial cells in distinct angiogenic states". Eur. J. Biochem. 267 (9): 2820–30. doi:10.1046/j.1432-1327.2000.01325.x. PMID 10785405.
Shindo T, Kurihara H, Kuno K, et al. (2000). "ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function". J. Clin. Invest. 105 (10): 1345–52. doi:10.1172/JCI8635. PMC 315464. PMID 10811842.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Kuno K, Okada Y, Kawashima H, et al. (2000). "ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan". FEBS Lett. 478 (3): 241–5. doi:10.1016/S0014-5793(00)01854-8. PMID 10930576.
Sandy JD, Westling J, Kenagy RD, et al. (2001). "Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4". J. Biol. Chem. 276 (16): 13372–8. doi:10.1074/jbc.M009737200. PMID 11278559.
Wei P, Zhao YG, Zhuang L, et al. (2002). "Protein engineering and properties of human metalloproteinase and thrombospondin 1". Biochem. Biophys. Res. Commun. 293 (1): 478–88. doi:10.1016/S0006-291X(02)00255-3. PMID 12054626.
Rodríguez-Manzaneque JC, Westling J, Thai SN, et al. (2002). "ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors". Biochem. Biophys. Res. Commun. 293 (1): 501–8. doi:10.1016/S0006-291X(02)00254-1. PMID 12054629.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Luque A, Carpizo DR, Iruela-Arispe ML (2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–65. doi:10.1074/jbc.M212964200. PMID 12716911.
Russell DL, Doyle KM, Ochsner SA, et al. (2004). "Processing and localization of ADAMTS-1 and proteolytic cleavage of versican during cumulus matrix expansion and ovulation". J. Biol. Chem. 278 (43): 42330–9. doi:10.1074/jbc.M300519200. PMID 12907688.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

Vanjski linkovi[uredi | uredi izvor]

The MEROPS online database for peptidases and their inhibitors: M12.222 Arhivirano 18. 4. 2021. na Wayback Machine
[https://web.archive.org/web/20111007022934/http://atlasgeneticsoncology.org/Genes/ADAMTS1ID574ch21q21.html Arhivirano 7. 10. 2011. na Wayback Machine ADAMTS1 on the Atlas of Genetics and Cytogenetics in Oncology and Haematology|Atlas of Genetics and Oncology]
Lokacija ljudskog genoma ADAMTS1 i stranica sa detaljima o genu ADAMTS1 u UCSC Genome Browseru.
Q9UHI8

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154734 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022893 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10438512-5] Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML (septembar 1999). "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity". J Biol Chem. 274 (33): 23349–57. doi:10.1074/jbc.274.33.23349. PMID 10438512.

[entrez-6] "Entrez Gene: ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1".

[pmid12716911-7] Luque A, Carpizo DR, Iruela-Arispe ML (juni 2003). "ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165". J. Biol. Chem. 278 (26): 23656–65. doi:10.1074/jbc.M212964200. PMID 12716911.

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p r u Proteaze: metaloendopeptidaze (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Ostali	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24