S Wikipedije, slobodne enciklopedije
Treonin-aspartaza 1 je enzim koji je kod ljudi kodiran genom TASP1 .[5] [6]
Ovaj gen kodira endopeptidazu koja cijepa specifične supstrate slijedeći aspartatne ostatke Kodirani protein prolazi posttranslacijsku autoproteolitsku obradu da bi se generirale alfa i beta podjedinice, koje se ponovno okupljaju u aktivni alfa2-beta2 heterotetramer. Potrebno je cijepati MLL , protein potreban za održavanje ekspresije gena HOX i TFIIA , bazni faktor transkripcije . Utvrđeno je da cijepanje transkripcijskog faktora II A pokreće spermatogenezu .[7]
Opisane su alternativno prerađene varijante transkripta, ali njihova biološka valjanost nije utvrđena.[6]
Simboli
10 20 30 40 50
MTMEKGMSSG EGLPSRSSQV SAGKITAKEL ETKQSYKEKR GGFVLVHAGA
GYHSESKAKE YKHVCKRACQ KAIEKLQAGA LATDAVTAAL VELEDSPFTN
AGMGSNLNLL GEIECDASIM DGKSLNFGAV GALSGIKNPV SVANRLLCEG
QKGKLSAGRI PPCFLVGEGA YRWAVDHGIP SCPPNIMTTR FSLAAFKRNK
RKLELAERVD TDFMQLKKRR QSSEKENDSG TLDTVGAVVV DHEGNVAAAV
SSGGLALKHP GRVGQAALYG CGCWAENTGA HNPYSTAVST SGCGEHLVRT
ILARECSHAL QAEDAHQALL ETMQNKFISS PFLASEDGVL GGVIVLRSCR
CSAEPDSSQN KQTLLVEFLW SHTTESMCVG YMSAQDGKAK THISRLPPGA
VAGQSVAIEG GVCRLESPVN
Taspaza1 je prekomjerno izražena u primarnim ljudskim karcinomima i funkcionira kao neonkogen ovisna proteaza , koja koordinira karcinomsku proliferaciju ćelija i apoptozu . Zato taspaza 1 može poslužiti kao nova terapijska meta protiv raka.[8]
^ a b c GRCh38: Ensembl release 89: ENSG00000089123 - Ensembl , maj 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039033 - Ensembl , maj 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hsieh JJ, Cheng EH, Korsmeyer SJ (Nov 2003). "Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression". Cell . 115 (3): 293–303. doi :10.1016/S0092-8674(03)00816-X . PMID 14636557 . S2CID 18952302 .
^ a b "Entrez Gene: TASP1 taspase, threonine aspartase, 1" .
^ Oyama, T; Sasagawa, S; Takeda, S; Hess, R. A.; Lieberman, P. M.; Cheng, E. H.; Hsieh, J. J. (2013). "Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs" . Developmental Cell . 27 (2): 188–200. doi :10.1016/j.devcel.2013.09.025 . PMC 3947863 . PMID 24176642 .
^ Chen DY, Liu H, Takeda S, Tu HC, Sasagawa S, Van Tine BA, Lu D, Cheng EH, Hsieh JJ (juli 2010). "Taspase1 functions as a non-oncogene addiction protease that coordinates cancer cell proliferation and apoptosis" . Cancer Res . 70 (13): 5358–67. doi :10.1158/0008-5472.CAN-10-0027 . PMC 2909739 . PMID 20516119 .
Zhou H, Spicuglia S, Hsieh JJ, et al. (2006). "Uncleaved TFIIA is a substrate for taspase 1 and active in transcription" . Mol. Cell. Biol . 26 (7): 2728–35. doi :10.1128/MCB.26.7.2728-2735.2006 . PMC 1430320 . PMID 16537915 .
Khan JA, Dunn BM, Tong L (2006). "Crystal structure of human Taspase1, a crucial protease regulating the function of MLL". Structure . 13 (10): 1443–52. doi :10.1016/j.str.2005.07.006 . PMID 16216576 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Hsieh JJ, Ernst P, Erdjument-Bromage H, et al. (2003). "Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization" . Mol. Cell. Biol . 23 (1): 186–94. doi :10.1128/MCB.23.1.186-194.2003 . PMC 140678 . PMID 12482972 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71. doi :10.1038/414865a . PMID 11780052 .