S Wikipedije, slobodne enciklopedije
Hromoboksni homolog 7 jest protein koji je kod ljudi kodiran genom CBX7 sa hromosoma 22 .[1] ekspresija gena CBX7 korelira sa malignim oblikom karcinomom štitnjače .[2]
Dužina polipeptidnog lanca je 251 aminokiselina , a molekulska težina
28.341 Da .
10 20 30 40 50 MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD PRLVMAYEEK EERDRASGYR KRGPKPKRLL LQRLYSMDLR SSHKAKGKEK LCFSLTCPLG SGSPEGVVKA GAPELVDKGP LVPTLPFPLR KPRKAHKYLR LSRKKFPPRG PNLESHSHRR ELFLQEPPAP DVLQAAGEWE PAAQPPEEEA DADLAEGPPP WTPALPSSEV TVTDITANSI TVTFREAQAA EGFFRDRSGK F
Obavljeno je 26 testova i prijavljena su tri značajno nenormalna fenotipa . Homozigotne mutantne odrasle ženke pokazale su smanjen odgovor na hipertermiju izazvanu stresom i imale su povećan broj crvenih krvnih zrnaca . Kada je pregledana epiderma repa , životinje oba spola imale su fenotip integumenta .[7]
Yap KL, Li S, Muñoz-Cabello AM, Raguz S, Zeng L, Mujtaba S, et al. (June 2010). "Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a" . Molecular Cell . 38 (5): 662–74. doi :10.1016/j.molcel.2010.03.021 . PMC 2886305 PMID 20541999 . Federico A, Pallante P, Bianco M, Ferraro A, Esposito F, Monti M, et al. (September 2009). "Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein" . Cancer Research . 69 (17): 7079–87. doi :10.1158/0008-5472.CAN-09-1542 PMID 19706751 . Pallante P, Terracciano L, Carafa V, Schneider S, Zlobec I, Lugli A, et al. (August 2010). "The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients". European Journal of Cancer . 46 (12): 2304–13. doi :10.1016/j.ejca.2010.05.011 . PMID 20542683 . Zhang XW, Zhang L, Qin W, Yao XH, Zheng LZ, Liu X, et al. (August 2010). "Oncogenic role of the chromobox protein CBX7 in gastric cancer" . Journal of Experimental & Clinical Cancer Research . 29 (1): 114. doi :10.1186/1756-9966-29-114 . PMC 2933612 PMID 20723236 . Hu CK, Wang W, Brind'Amour J, Singh PP, Reeves GA, Lorincz MC, Alvarado AS, Brunet A (February 2020). "Vertebrate diapause preserves organisms long term through Polycomb complex members" . Science . 367 (6480): 870–874. doi :10.1126/science.aaw2601 . PMC 7532943 PMID 32079766 . 
