CCL13

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski (C-C motivni) ligand 13
Hemokinski (C-C motivni) ligand 13
Identifikatori
Simbol	CCL13
Alt. simboli	SCYA13, MCP-4, NCC-1, SCYL1, CKb10
NCBI gen	6357
HGNC	10611
OMIM	601391
RefSeq	NM_005408
UniProt	Q99616
Ostali podaci
Lokus	Hrom. 17 q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL13
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	2RA4
Identifikatori
Aliasi	CCL13
Vanjski ID-jevi	OMIM: 601391 MGI: 98259 HomoloGene: 2241 GeneCards: CCL13
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	34,358,610 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	82,037,453 bp
Ontologija gena
Molekularna funkcija	• cytokine activity; • chemokine activity; • CCR chemokine receptor binding; • signaling receptor binding; • GO:0001948, GO:0016582 vezivanje za proteine;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• monocyte chemotaxis; • cell-cell signaling; • eosinophil chemotaxis; • Hemotaksija; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • cytoskeleton organization; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • GO:0072468 Transdukcija signala; • inflammatory response; • antimicrobial humoral immune response mediated by antimicrobial peptide; • cellular calcium ion homeostasis; • neutrophil chemotaxis; • lymphocyte chemotaxis; • chemokine-mediated signaling pathway; • cellular response to interferon-gamma; • cellular response to interleukin-1; • cellular response to tumor necrosis factor; • regulation of signaling receptor activity; • G protein-coupled receptor signaling pathway; • cell chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	6357
	20296
	ENSG00000181374
	ENSMUSG00000035385
	Q99616
	P10148
	NM_005408
	NM_011333
	NP_005399
	NP_035463
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 13 (CCL13) jest mali citokin koji pripada porodici CC hemokina. Njegov gen nalazi se na ljudskom hromosomu 17 unutar velike grupe drugih CC-hemokina.^[5]^[6] CCL13 inducira hemotaksiju u monocitima, eozinofilima, T-limfocitima i bazofilima, vezanjem G-proteina na ćelijskoj površini, preko hemokinskih receptora, kao što su CCR2, CCR3 i CCR5.^[7] Aktivnost ovog hemokina uključena je u alergijske reakcije kao što je astma.^[8] CCL13 mogu inducirati upalni citokini interleukin-1 i TNF-α.

Aminokiselinska sekvenca[uredi | uredi izvor]

Dužina polipeptidnog lanca je 98 aminokiselina, a molekulska težina 10.986 Da.^[9]

10		20		30		40		50
MKVSAVLLCL		LLMTAAFNPQ		GLAQPDALNV		PSTCCFTFSS		KKISLQRLKS
YVITTSRCPQ		KAVIFRTKLG		KEICADPKEK		WVQNYMKHLG		RKAHTLKT

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

Reference[uredi | uredi izvor]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181374 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035385 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626
^ Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
^ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
^ Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.
^ "UniProt, Q99616". Pristupljeno 28. 6. 2021.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181374 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035385 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626

[6] Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.

[7] Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.

[8] Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.

[UniProt-9] "UniProt, Q99616". Pristupljeno 28. 6. 2021.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]